DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment MFS1 and Slc17a4

DIOPT Version :9

Sequence 1:	NP_726254.1	Gene:	MFS1 / 246519	FlyBaseID:	FBgn0050272	Length:	497	Species:	Drosophila melanogaster
Sequence 2:	NP_795990.2	Gene:	Slc17a4 / 319848	MGIID:	2442850	Length:	492	Species:	Mus musculus

Alignment Length:	463	Identity:	123/463 - (26%)
Similarity:	221/463 - (47%)	Gaps:	36/463 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 RHLQTFLLFLSIVVNYMAKFNAGVAVVAMT---------NAENTNP---------------NFPE 54
            ||...|:|.|.....|..:.|...|:.||.         ||....|               ..|.
Mouse    33 RHGLAFILHLCNFSIYTQQMNLSFAITAMVNTTVASSQLNASTERPPTNSQDVWNETLQESKAPV 97

  Fly    55 YDWNEMERSYILSSFFWGYILTQFMGGWLCRRYGARITMFVSTIGSALLVVLIPWCVSWGGWQAY 119
            |||....:..:|||..:|..:.....|::...:||:..:.:..:.|::|.:.||.... .|....
Mouse    98 YDWTPEIQGILLSSLSYGSFIAPIPTGYVAGVFGAKYVVGLGLLISSVLTLFIPLAAD-AGVALL 161

  Fly   120 CAIRMSMGLFQGFLFPCIHAHLANWCPVKERNRLGALANTGIDCGTLVAMFASGLLAASSIGWPG 184
            ..:|:..|:.|..:....::..|.|.|.:||::|..:|.:|...||.:.:.|.||: ..::|||.
Mouse   162 IVLRVIQGMAQVMVLTGQYSLWAKWAPPQERSQLITIAASGSMLGTFLVLIAGGLI-CQALGWPY 225

  Fly   185 IFYVSCGVGVLWCIVWWIFGANQPRESKFIGEAELNYIETSINSSRKAEEAELKATGPIPVPWKA 249
            |||:..|:|...|::|:....:.|:...||...|..||..|:    ..|:..|..:.||    ||
Mouse   226 IFYIFGGIGCACCLLWFPLVYDDPQNHPFISTGERRYITCSL----AQEDCSLGWSLPI----KA 282

  Fly   250 IWTSVPFWALMVTRCCQSWGYSTLQTEMPAYMNGVLLMDMKSNALYSALPYLTSWVMAFVYLIIA 314
            :..|:|.||::|:..|:.|..||:....|.|::.||..:::.:.:.||||::...|...:..::|
Mouse   283 MVKSLPLWAIVVSYFCEYWLLSTVMAYTPTYISSVLQANLRDSGILSALPFMFGCVCIILGGLLA 347

  Fly   315 DILLTRGIMSITGIRKSVNSIAFFVPAAALIGVSFLDNTQKTLAVVLMCANVGINAGSTIGSTIN 379
            |.||:|.|:.:..|||...::.....:..|:.:.::.:::.|....|:.::|..:...: |:.||
Mouse   348 DFLLSRKILRLVTIRKLFTAVGVLASSGILLPLPWVRSSRSTTMAFLVLSSVFASLCDS-GALIN 411

  Fly   380 TIDLSPNHAGILMGIVNTASNIVPILTPLLVGIIVKDDHDREQWQIVFIISAVIFCVGNIVYVAF 444
            .:|::|.:||.|.|::...|.:...:.|.:.|..:..|.: ..|:.||.::|.|..||.:.|:.|
Mouse   412 FLDIAPRYAGFLKGLLQVFSYLAGGIAPTVAGFFISQDSE-FGWRNVFFLAAAIDVVGLLFYLIF 475

  Fly   445 GKMVNQPW 452
            .:...|.|
Mouse   476 SRAEVQDW 483

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MFS1	NP_726254.1	MFS	18..444	CDD:119392	118/449 (26%)
MFS1	NP_726254.1	2A0114euk	19..456	CDD:129972	121/458 (26%)
Slc17a4	NP_795990.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..20
		2A0114euk	27..486	CDD:129972	123/463 (27%)
		MFS	98..475	CDD:119392	106/388 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167838710
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2532
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000034
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.740