DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment MFS1 and Slc17a8

DIOPT Version :9

Sequence 1:	NP_726254.1	Gene:	MFS1 / 246519	FlyBaseID:	FBgn0050272	Length:	497	Species:	Drosophila melanogaster
Sequence 2:	NP_714947.1	Gene:	Slc17a8 / 266767	RGDID:	628870	Length:	588	Species:	Rattus norvegicus

Alignment Length:	490	Identity:	145/490 - (29%)
Similarity:	234/490 - (47%)	Gaps:	37/490 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 IGQRHLQTFLLFLSIVVNYMAKFNAGVAVVAMTNAENT----NPNF--PEYDWNEMERSYILSSF 69
            |.:|::...:..|...:::..:.|.|||:|.|.|....    .|..  .:::|:......|..||
  Rat    72 IPKRYIIAVMSGLGFCISFGIRCNLGVAIVEMVNNSTVYVDGKPEIQTAQFNWDPETVGLIHGSF 136

  Fly    70 FWGYILTQFMGGWLCRRYGARITMFVSTIGSALLVVLIPWC--VSWGGWQAYCAIRMSMGLFQGF 132
            |||||:||..||::..::.|......:...::.|.:.||..  |.:|   ....:|:..||.:|.
  Rat   137 FWGYIVTQIPGGFISNKFAANRVFGAAIFLTSTLNMFIPSAARVHYG---CVMCVRILQGLVEGV 198

  Fly   133 LFPCIHAHLANWCPVKERNRLGALANTGIDCGTLVAMFASGLLAASSIGWPGIFYVSCGVGVLWC 197
            .:|..|...:.|.|..||:||...:..|...|.:|||..:|:| ...|||..:||:....|::|.
  Rat   199 TYPACHGMWSKWAPPLERSRLATTSFCGSYAGAVVAMPLAGVL-VQYIGWASVFYIYGMFGIIWY 262

  Fly   198 IVWWIFGANQPRESKFIGEAELNYIETSINSSRKAEEAELKATGPIPVPWKAIWTSVPFWALMVT 262
            :.|.:.....|.....|...|..||||||     .|.|.|.:......||:..:||:|.:|::|.
  Rat   263 MFWLLQAYECPAVHPTISNEERTYIETSI-----GEGANLASLSKFNTPWRRFFTSLPVYAIIVA 322

  Fly   263 RCCQSWGYSTLQTEMPAYMNGVLLMDMKSNALYSALPYLTSWVMAFVYLI---IADILLTRGIMS 324
            ..|:||.:..|....|||...|....:....|.||:|::   ||..|..|   :||.|.:|.|::
  Rat   323 NFCRSWTFYLLLISQPAYFEEVFGFAISKVGLLSAVPHM---VMTIVVPIGGQLADYLRSRKILT 384

  Fly   325 ITGIRKSVNSIAFFVPAAALIGVSFLDNTQKTLAVVLMCANVGINAGSTIGSTINTIDLSPNHAG 389
            .|.:||.:|...|.:.|..|:.|.|  :..|.:|:..:...||.:..:..|..:|.:|::|.:|.
  Rat   385 TTAVRKIMNCGGFGMEATLLLVVGF--SHTKGVAISFLVLAVGFSGFAISGFNVNHLDIAPRYAS 447

  Fly   390 ILMGIVNTASNIVPILTPLLVGIIVKDDHDREQWQIVFIISAVIFCVGNIVYVAFGKMVNQPWDA 454
            |||||.|....:..::.||:||.:.| ...||:||.||:|:|::...|.|.|..|.....|.|..
  Rat   448 ILMGISNGVGTLSGMVCPLIVGAMTK-HKTREEWQNVFLIAALVHYSGVIFYGVFASGEKQDWAD 511

  Fly   455 PDFMDKQRSSNLQEVGHSKALEAQGSEKVEEAKRN 489
            |:.:.:::...:.:           .|..||.:.|
  Rat   512 PENLSEEKCGIIDQ-----------DELAEETELN 535

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MFS1	NP_726254.1	MFS	18..444	CDD:119392	135/436 (31%)
MFS1	NP_726254.1	2A0114euk	19..456	CDD:129972	138/447 (31%)
Slc17a8	NP_714947.1	MFS_SLC17A6_7_8_VGluT	79..502	CDD:340940	135/437 (31%)
Slc17a8	NP_714947.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	539..588
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166342499
Domainoid	1	1.000	47	1.000	Domainoid score	I11657
eggNOG	1	0.900	-	-		E1_KOG2532
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D497052at2759
OrthoFinder	1	1.000	-	-		FOG0000034
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.750