DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment MFS1 and SLC17A5

DIOPT Version :9

Sequence 1:	NP_726254.1	Gene:	MFS1 / 246519	FlyBaseID:	FBgn0050272	Length:	497	Species:	Drosophila melanogaster
Sequence 2:	NP_001369562.1	Gene:	SLC17A5 / 26503	HGNCID:	10933	Length:	533	Species:	Homo sapiens

Alignment Length:	434	Identity:	120/434 - (27%)
Similarity:	214/434 - (49%)	Gaps:	39/434 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 RHLQTFLLFLSIVVNYMAKFNAGVAVVAMTNAENT---------------------NPNFPEYDW 57
            |:....|.|....:.|..:.|..||:|.|.::..|                     |....:|.|
Human    39 RYNLAILAFFGFFIVYALRVNLSVALVDMVDSNTTLEDNRTSKACPEHSAPIKVHHNQTGKKYQW 103

  Fly    58 NEMERSYILSSFFWGYILTQFMGGWLCRRYGARITMFVSTIGSALLVVLIPWCVSWG-GWQAYCA 121
            :...:.:||.|||:|||:||..||::..:.|.::.:....:|:|:|.:..|.....| |  ....
Human   104 DAETQGWILGSFFYGYIITQIPGGYVASKIGGKMLLGFGILGTAVLTLFTPIAADLGVG--PLIV 166

  Fly   122 IRMSMGLFQGFLFPCIHAHLANWCPVKERNRLGALANTGIDCGTLVAMFASGLLAASSIGWPGIF 186
            :|...||.:|..||.:||..::|.|..||::|.:::..|...||::::..||:: ...:.|..:|
Human   167 LRALEGLGEGVTFPAMHAMWSSWAPPLERSKLLSISYAGAQLGTVISLPLSGII-CYYMNWTYVF 230

  Fly   187 YVSCGVGVLWCIVW-WIFGANQPRESKFIGEAELNYIETSINSSRKAEEAELKATGPIPVPWKAI 250
            |....:|:.|.::| |:. ::.|::.|.|...|..||.:|:.:...::::         |||..|
Human   231 YFFGTIGIFWFLLWIWLV-SDTPQKHKRISHYEKEYILSSLRNQLSSQKS---------VPWVPI 285

  Fly   251 WTSVPFWALMVTRCCQSWGYSTLQTEMPAYMNGVLLMDMKSNALYSALPYLTSWVMAFVYLIIAD 315
            ..|:|.||::|.....:|.:.||.|.:|.||..:|..:::.|...|:||||.||:...:....||
Human   286 LKSLPLWAIVVAHFSYNWTFYTLLTLLPTYMKEILRFNVQENGFLSSLPYLGSWLCMILSGQAAD 350

  Fly   316 ILLTRGIMSITGIRKSVNSIAFFVPAAALIGVSFLDNTQKTLAVVLMCANVGINAGSTIGSTINT 380
            .|..:...|...:|:..:.|....||..|:...|: ....:|||..:..:..:....:.|.:||.
Human   351 NLRAKWNFSTLCVRRIFSLIGMIGPAVFLVAAGFI-GCDYSLAVAFLTISTTLGGFCSSGFSINH 414

  Fly   381 IDLSPNHAGILMGIVNTASNIVPILTPLLVGIIVKDDHDREQWQ 424
            :|::|::||||:||.||.:.|..::.|::...:..|  ...||:
Human   415 LDIAPSYAGILLGITNTFATIPGMVGPVIAKSLTPD--AGVQWR 456

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MFS1	NP_726254.1	MFS	18..444	CDD:119392	119/430 (28%)
MFS1	NP_726254.1	2A0114euk	19..456	CDD:129972	119/429 (28%)
SLC17A5	NP_001369562.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..24
		Dileucine internalization motif	22..23
		MFS_SLC17A5	42..458	CDD:340939	119/431 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165148586
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2532
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000034
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11662
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.840