DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment MFS1 and SLC17A8

DIOPT Version :9

Sequence 1:	NP_726254.1	Gene:	MFS1 / 246519	FlyBaseID:	FBgn0050272	Length:	497	Species:	Drosophila melanogaster
Sequence 2:	NP_647480.1	Gene:	SLC17A8 / 246213	HGNCID:	20151	Length:	589	Species:	Homo sapiens

Alignment Length:	492	Identity:	144/492 - (29%)
Similarity:	237/492 - (48%)	Gaps:	27/492 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 QRHLQTFLLFLSIVVNYMAKFNAGVAVVAMTNAENT----NPNF--PEYDWNEMERSYILSSFFW 71
            :|::...:..|...:::..:.|.|||:|.|.|....    .|..  .:::|:......|..||||
Human    74 KRYIIAIMSGLGFCISFGIRCNLGVAIVEMVNNSTVYVDGKPEIQTAQFNWDPETVGLIHGSFFW 138

  Fly    72 GYILTQFMGGWLCRRYGARITMFVSTIGSALLVVLIPWC--VSWGGWQAYCAIRMSMGLFQGFLF 134
            |||:||..||::..::.|......:...::.|.:.||..  |.:|   ....:|:..||.:|..:
Human   139 GYIMTQIPGGFISNKFAANRVFGAAIFLTSTLNMFIPSAARVHYG---CVMCVRILQGLVEGVTY 200

  Fly   135 PCIHAHLANWCPVKERNRLGALANTGIDCGTLVAMFASGLLAASSIGWPGIFYVSCGVGVLWCIV 199
            |..|...:.|.|..||:||...:..|...|.:|||..:|:| ...|||..:||:....|::|.:.
Human   201 PACHGMWSKWAPPLERSRLATTSFCGSYAGAVVAMPLAGVL-VQYIGWSSVFYIYGMFGIIWYMF 264

  Fly   200 WWIFGANQPRESKFIGEAELNYIETSINSSRKAEEAELKATGPIPVPWKAIWTSVPFWALMVTRC 264
            |.:.....|.....|...|..||||||     .|.|.:.:......|||..:||:|.:|::|...
Human   265 WLLQAYECPAAHPTISNEEKTYIETSI-----GEGANVVSLSKFSTPWKRFFTSLPVYAIIVANF 324

  Fly   265 CQSWGYSTLQTEMPAYMNGVLLMDMKSNALYSALPYLTSWVMAFVYLI---IADILLTRGIMSIT 326
            |:||.:..|....|||...|....:....|.||:|::   ||..|..|   :||.|.:|.|::.|
Human   325 CRSWTFYLLLISQPAYFEEVFGFAISKVGLLSAVPHM---VMTIVVPIGGQLADYLRSRQILTTT 386

  Fly   327 GIRKSVNSIAFFVPAAALIGVSFLDNTQKTLAVVLMCANVGINAGSTIGSTINTIDLSPNHAGIL 391
            .:||.:|...|.:.|..|:.|.|  :..|.:|:..:...||.:..:..|..:|.:|::|.:|.||
Human   387 AVRKIMNCGGFGMEATLLLVVGF--SHTKGVAISFLVLAVGFSGFAISGFNVNHLDIAPRYASIL 449

  Fly   392 MGIVNTASNIVPILTPLLVGIIVKDDHDREQWQIVFIISAVIFCVGNIVYVAFGKMVNQPWDAPD 456
            |||.|....:..::.||:||.:.: ...||:||.||:|:|::...|.|.|..|.....|.|..|:
Human   450 MGISNGVGTLSGMVCPLIVGAMTR-HKTREEWQNVFLIAALVHYSGVIFYGVFASGEKQEWADPE 513

  Fly   457 FMDKQRSSNLQEVGHSKALEAQGSEKVEEAKRNESEG 493
            .:.:::...:.:...::.:|. ..|.....|:..|.|
Human   514 NLSEEKCGIIDQDELAEEIEL-NHESFASPKKKMSYG 549

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MFS1	NP_726254.1	MFS	18..444	CDD:119392	134/436 (31%)
MFS1	NP_726254.1	2A0114euk	19..456	CDD:129972	137/447 (31%)
SLC17A8	NP_647480.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	40..61
		2A0114euk	75..513	CDD:129972	138/452 (31%)
		MFS	80..502	CDD:119392	134/436 (31%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	559..589
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165148604
Domainoid	1	1.000	49	1.000	Domainoid score	I11776
eggNOG	1	0.900	-	-		E1_KOG2532
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D497052at2759
OrthoFinder	1	1.000	-	-		FOG0000034
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.750