DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment MFS1 and Slc17a8

DIOPT Version :9

Sequence 1:	NP_726254.1	Gene:	MFS1 / 246519	FlyBaseID:	FBgn0050272	Length:	497	Species:	Drosophila melanogaster
Sequence 2:	NP_892004.1	Gene:	Slc17a8 / 216227	MGIID:	3039629	Length:	601	Species:	Mus musculus

Alignment Length:	490	Identity:	146/490 - (29%)
Similarity:	234/490 - (47%)	Gaps:	37/490 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 IGQRHLQTFLLFLSIVVNYMAKFNAGVAVVAMTNAENT----NPNF--PEYDWNEMERSYILSSF 69
            |.:|::...:..|...:::..:.|.|||:|.|.|....    .|..  .:::|:......|..||
Mouse    85 IPKRYIIAVMSGLGFCISFGIRCNLGVAIVEMVNNSTVYVDGKPEIQTAQFNWDPETVGLIHGSF 149

  Fly    70 FWGYILTQFMGGWLCRRYGARITMFVSTIGSALLVVLIPWC--VSWGGWQAYCAIRMSMGLFQGF 132
            |||||:||..||::..::.|......:...::.|.:.||..  |.:|   ....:|:..||.:|.
Mouse   150 FWGYIVTQIPGGFISNKFAASRVFGAAIFLTSTLNMFIPSAARVHYG---CVMGVRILQGLVEGV 211

  Fly   133 LFPCIHAHLANWCPVKERNRLGALANTGIDCGTLVAMFASGLLAASSIGWPGIFYVSCGVGVLWC 197
            .:|..|...:.|.|..||:||...:..|...|.:|||..:|:| ...|||..:||:....|::|.
Mouse   212 TYPACHGMWSKWAPPLERSRLATTSFCGSYAGAVVAMPLAGVL-VQYIGWASVFYIYGMFGIIWY 275

  Fly   198 IVWWIFGANQPRESKFIGEAELNYIETSINSSRKAEEAELKATGPIPVPWKAIWTSVPFWALMVT 262
            :.|.:.....|.....|..||..||||||     .|.|.|.:......||:..:||:|.:|::|.
Mouse   276 MFWLLQAYECPAAHPTISNAERTYIETSI-----GEGANLASLSKFNTPWRRFFTSLPVYAIIVA 335

  Fly   263 RCCQSWGYSTLQTEMPAYMNGVLLMDMKSNALYSALPYLTSWVMAFVYLI---IADILLTRGIMS 324
            ..|:||.:..|....|||...|....:....|.||:|::   ||..|..|   :||.|.:|.|::
Mouse   336 NFCRSWTFYLLLISQPAYFEEVFGFAISKVGLLSAVPHM---VMTIVVPIGGQLADYLRSRKILT 397

  Fly   325 ITGIRKSVNSIAFFVPAAALIGVSFLDNTQKTLAVVLMCANVGINAGSTIGSTINTIDLSPNHAG 389
            .|.:||.:|...|.:.|..|:.|.|  :..|.:|:..:...||.:..:..|..:|.:|::|.:|.
Mouse   398 TTAVRKIMNCGGFGMEATLLLVVGF--SHTKGVAISFLVLAVGFSGFAISGFNVNHLDIAPRYAS 460

  Fly   390 ILMGIVNTASNIVPILTPLLVGIIVKDDHDREQWQIVFIISAVIFCVGNIVYVAFGKMVNQPWDA 454
            |||||.|....:..::.||:||.:.| ...||:||.||:|:|::...|.|.|..|.....|.|..
Mouse   461 ILMGISNGVGTLSGMVCPLIVGAMTK-HKTREEWQNVFLIAALVHYSGVIFYGVFASGEKQDWAD 524

  Fly   455 PDFMDKQRSSNLQEVGHSKALEAQGSEKVEEAKRN 489
            |:.:.:.:...:.:           .|..||.:.|
Mouse   525 PENLSEDKCGIIDQ-----------DELAEETELN 548

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MFS1	NP_726254.1	MFS	18..444	CDD:119392	136/436 (31%)
MFS1	NP_726254.1	2A0114euk	19..456	CDD:129972	139/447 (31%)
Slc17a8	NP_892004.1	2A0114euk	88..526	CDD:129972	140/452 (31%)
		MFS	93..515	CDD:119392	136/436 (31%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	576..601
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	49	1.000	Domainoid score	I11710
eggNOG	1	0.900	-	-		E1_KOG2532
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D497052at2759
OrthoFinder	1	1.000	-	-		FOG0000034
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.820