DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment MFS1 and Slc17a7

DIOPT Version :9

Sequence 1:	NP_726254.1	Gene:	MFS1 / 246519	FlyBaseID:	FBgn0050272	Length:	497	Species:	Drosophila melanogaster
Sequence 2:	XP_038966881.1	Gene:	Slc17a7 / 116638	RGDID:	620101	Length:	585	Species:	Rattus norvegicus

Alignment Length:	529	Identity:	155/529 - (29%)
Similarity:	249/529 - (47%)	Gaps:	58/529 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MTAETNTGPMIG-------QRHLQTFLLFLSIVVNYMAKFNAGVAVVAMTNAENTN--------- 49
            :|..|...|::.       :|::...:..|...:::..:.|.|||:|:|.|...|:
  Rat    42 VTTHTRDPPVVDCTCFGLPRRYIIAIMSGLGFCISFGIRCNLGVAIVSMVNNSTTHRGGHVVVQT 106

  Fly    50 ------------PNF----------PEYDWNEMERSYILSSFFWGYILTQFMGGWLCRRYGARIT 92
                        |..          .:::|:......|..|||||||:||..||::|:::.|...
  Rat   107 PYRSVHKQEAVTPTVGDIQGGDTEKAQFNWDPETVGLIHGSFFWGYIVTQIPGGFICQKFAANRV 171

  Fly    93 MFVSTIGSALLVVLIPWC--VSWGGWQAYCAI--RMSMGLFQGFLFPCIHAHLANWCPVKERNRL 153
            ...:.:.::.|.:|||..  |.:|     |.|  |:..||.:|..:|..|...:.|.|..||:||
  Rat   172 FGFAIVATSTLNMLIPSAARVHYG-----CVIFVRILQGLVEGVTYPACHGIWSKWAPPLERSRL 231

  Fly   154 GALANTGIDCGTLVAMFASGLLAASSIGWPGIFYVSCGVGVLWCIVWWIFGANQPRESKFIGEAE 218
            ...|..|...|.:|||..:|:|...| ||..:|||....|:.|.:.|.:.....|.....|.|.|
  Rat   232 ATTAFCGSYAGAVVAMPLAGVLVQYS-GWSSVFYVYGSFGIFWYLFWLLVSYESPALHPSISEEE 295

  Fly   219 LNYIETSINSSRKAEEAELKATGPIPVPWKAIWTSVPFWALMVTRCCQSWGYSTLQTEMPAYMNG 283
            ..|||.:|..|.|......|    ...||:..:||:|.:|::|...|:||.:..|....|||...
  Rat   296 RKYIEDAIGESAKLMNPVTK----FNTPWRRFFTSMPVYAIIVANFCRSWTFYLLLISQPAYFEE 356

  Fly   284 VLLMDMKSNALYSALPYLTSWVMAFVYLIIADILLTRGIMSITGIRKSVNSIAFFVPAAALIGVS 348
            |...::....|.||||:|...::..:...|||.|.:|.|||.|.:||.:|...|.:.|..|:.|.
  Rat   357 VFGFEISKVGLVSALPHLVMTIIVPIGGQIADFLRSRHIMSTTNVRKLMNCGGFGMEATLLLVVG 421

  Fly   349 FLDNTQKTLAVVLMCANVGINAGSTIGSTINTIDLSPNHAGILMGIVNTASNIVPILTPLLVGII 413
            :  :..|.:|:..:...||.:..:..|..:|.:|::|.:|.|||||.|....:..::.|::||.:
  Rat   422 Y--SHSKGVAISFLVLAVGFSGFAISGFNVNHLDIAPRYASILMGISNGVGTLSGMVCPIIVGAM 484

  Fly   414 VKDDHDREQWQIVFIISAVIFCVGNIVYVAFGKMVNQPWDAPDFMDKQRSSNLQEVGHSKALEAQ 478
            .| ...||:||.||:|::::...|.|.|..|.....|||..|:.|.:::..   .|||.:...:.
  Rat   485 TK-HKTREEWQYVFLIASLVHYGGVIFYGVFASGEKQPWAEPEEMSEEKCG---FVGHDQLAGSD 545

  Fly   479 GSEKVEEAK 487
            .||..:|.:
  Rat   546 ESEMEDEVE 554

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MFS1	NP_726254.1	MFS	18..444	CDD:119392	139/460 (30%)
MFS1	NP_726254.1	2A0114euk	19..456	CDD:129972	143/471 (30%)
Slc17a7	XP_038966881.1	MFS_SLC17A6_7_8_VGluT	66..515	CDD:340940	139/461 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166342463
Domainoid	1	1.000	47	1.000	Domainoid score	I11657
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D497052at2759
OrthoFinder	1	1.000	-	-		FOG0000034
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.850