DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment MFS1 and slc17a6

DIOPT Version :9

Sequence 1:	NP_726254.1	Gene:	MFS1 / 246519	FlyBaseID:	FBgn0050272	Length:	497	Species:	Drosophila melanogaster
Sequence 2:	XP_004913390.1	Gene:	slc17a6 / 101730310	XenbaseID:	XB-GENE-1011394	Length:	583	Species:	Xenopus tropicalis

Alignment Length:	518	Identity:	150/518 - (28%)
Similarity:	246/518 - (47%)	Gaps:	54/518 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 QRHLQTFLLFLSIVVNYMAKFNAGVAVVAMTNAENTN------PNFPEYDWNEMERSYILSSFFW 71
            :|::...:..|...:::..:.|.|||:|.|.|....:      ....:::|:......|..||||
Frog    69 RRYIIAIMSGLGFCISFGIRCNLGVAIVDMVNNSTIHHGGKIIKEKAKFNWDPEIVGMIHGSFFW 133

  Fly    72 GYILTQFMGGWLCRRYGARITMFVSTIGSALLVVLIPWC--VSWGGWQAYCAI--RMSMGLFQGF 132
            |||:||..||::..|..|......:.:.::.|.:|||..  |.:|     |.|  |:..||.:|.
Frog   134 GYIVTQIPGGYIASRLAANRVFGAAIVLTSTLNMLIPSAARVHYG-----CVIFVRILQGLVEGV 193

  Fly   133 LFPCIHAHLANWCPVKERNRLGALANTGIDCGTLVAMFASGLLAASSIGWPGIFYVSCGVGVLWC 197
            .:|..|...:.|.|..||:||...:..|...|.::||..:|:|...: ||..:|||....|::|.
Frog   194 TYPACHGIWSKWAPPLERSRLATTSFCGSYAGAVIAMPLAGILVQYT-GWSSVFYVYGCFGLVWY 257

  Fly   198 IVWWIFGANQPRESKFIGEAELNYIETSINSSRKAEEAELKATGPI---PVPWKAIWTSVPFWAL 259
            :.|.:.....|.:...|.:.|.||||.||..|       ....||:   ..||:..:||:|.:|:
Frog   258 LFWILVSYESPAKHPTITDEERNYIEESIGES-------ANILGPVEKFKTPWRKFFTSMPVYAI 315

  Fly   260 MVTRCCQSWGYSTLQTEMPAYMNGVLLMDMKSNALYSALPYLTSWVMAFVYLIIADILLTRGIMS 324
            :|...|:||.:..|....|||...|...::....:.||:|:|...::..:...|||.|.::.|:|
Frog   316 IVANFCRSWTFYLLLISQPAYFEEVFGFEISKVGMLSAVPHLVMTIIVPIGGQIADFLRSKQILS 380

  Fly   325 ITGIRKSVNSIAFFVPAAALIGVSFLDNTQKTLAVVLMCANVGINAGSTIGSTINTIDLSPNHAG 389
            .|.:||.:|...|.:.|..|:.|.:  :..|.:|:..:...||.:..:..|..:|.:|::|.:|.
Frog   381 TTTVRKIMNCGGFGMEATLLLVVGY--SHSKGVAISFLVLAVGFSGFAISGFNVNHLDIAPRYAS 443

  Fly   390 ILMGIVNTASNIVPILTPLLVGIIVKDDHDREQWQIVFIISAVIFCVGNIVYVAFGKMVNQPWDA 454
            |||||.|....:..::.||:||.:.| ...||:||.||:|:|::...|.|.|..|.....|||..
Frog   444 ILMGISNGVGTLSGMVCPLIVGAMTK-HKSREEWQYVFLIAALVHYGGVIFYGIFASGEKQPWAD 507

  Fly   455 PD--------FMDKQR--------SSNLQEVGHSKALEA---------QGSEKVEEAKRNESE 492
            |:        |:::..        |.|....|.:|:..|         .|.||.||..:.:.:
Frog   508 PEQTSDEKCGFINEDELAEEAGDISQNYINYGTAKSYGATTQMNTGWPNGWEKREEGVQGDGQ 570

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MFS1	NP_726254.1	MFS	18..444	CDD:119392	133/438 (30%)
MFS1	NP_726254.1	2A0114euk	19..456	CDD:129972	137/449 (31%)
slc17a6	XP_004913390.1	MFS_SLC17A6_7_8_VGluT	74..498	CDD:340940	133/439 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D497052at2759
OrthoFinder	1	1.000	-	-		FOG0000034
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.010