DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG30203 and spon1b

DIOPT Version :9

Sequence 1:	NP_725128.2	Gene:	CG30203 / 246514	FlyBaseID:	FBgn0050203	Length:	924	Species:	Drosophila melanogaster
Sequence 2:	XP_005174403.1	Gene:	spon1b / 58029	ZFINID:	ZDB-GENE-000427-10	Length:	804	Species:	Danio rerio

Alignment Length:	726	Identity:	218/726 - (30%)
Similarity:	315/726 - (43%)	Gaps:	161/726 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 IVLLILL------------------SSEVRGVCNRIPQGASGPRSPVDDNFKILIDGNPETYVPE 51
            :|||:.|                  |....|.|..:...|...|....:.|::.::|.||||.|.
Zfish     8 VVLLVFLNVFLIHSDAFKRDTAERHSRSEGGFCRILRTQARSARRDGQNEFRLKVEGEPETYQPG 72

  Fly    52 HQYNVSLSCPINMKFVSFTLVVEAEDPSAAFGGQDMTGHFELLGVGDTRFSTSCENMVENTNTNA 116
            ..|.|||.......|..|||:...|..... ...|..|.|:|:...||:|.|:|...|..:....
Zfish    73 STYRVSLYASSPSYFRGFTLIALKEGREGV-SPDDYAGTFKLIDESDTQFMTNCPPAVTESIPRR 136

  Fly   117 KIYIAVSWIAPRNPDSGCVLIKAGVVQHRDVWFLDDGFLTKRICPEEIDELNSLTPPLETCCACD 181
            :..|.|.|.||.: .||||.:||.|||.|.::|.|:|.||||:|  |.|.:.....|.:.||||.
Zfish   137 RTRIQVFWTAPPS-GSGCVTLKASVVQRRIIFFQDEGSLTKRLC--EKDPVAITEKPAQECCACG 198

  Fly   182 EAKYEIVLERKWARNTHWKDFP--SEDWRTRLGEVIGASHSHSYRYWAYGGRASKGMKELAEHGA 244
            .|||.:.....|:...|.||:|  :..|    ..:|||||:.||..|.|||.||:|:|:::|:|:
Zfish   199 TAKYRVTFYGNWSEKLHPKDYPRRANHW----SALIGASHTRSYVLWEYGGFASEGVKQVSEYGS 259

  Fly   245 TRTLENEIRENTQNGEVRTII--KAPGIPYRPKTF-GTTLANARLDPVHHQISLAAKIDPSPDWI 306
            ...:|.|||:  :..:|.|:|  ||....::|... ....|...:|.|.|.:|....:.|||||.
Zfish   260 PVKMEEEIRQ--KGDDVMTVIKTKAQWPAWQPLNIRAAPSAEFSVDRVRHLMSFLTMLGPSPDWN 322

  Fly   307 LGVAGLELCLSNCTWLERKVLNLYPWDIGTDSGPSYMSSDEPQVPPDVVRRITSSYPSDH-RSPF 370
            :|::|.:||..:|.|:::.|.:|.|||.|||||.||.|.::|.:|.:.:|.:||   .|| :|||
Zfish   323 VGLSGEDLCTRDCGWVQKLVKDLVPWDAGTDSGVSYESPNKPSIPQERIRPLTS---LDHPQSPF 384

  Fly   371 YDDTGAPMKPLATLYLTRKKLYIRECEEVP---------------QEG---PLECAVHPWNEWTN 417
            ||.:|.||.||..:.:.|......:|..||               :||   |..|....|:.|:.
Zfish   385 YDPSGGPMTPLGRVVVERIARKGEQCNTVPDTIDDIVADIAQEEKEEGDNTPETCIYSNWSPWSA 449

  Fly   418 C-STRCGQGYSHRQRSFK---NPNLAANFNCDRRLEEFRQCQGTQCGAAEEELEGEEPGLGMENP 478
            | |:.|.:|...|||..|   :|||..     ...::|..|.|..|  :|||
Zfish   450 CSSSTCDKGRRMRQRMLKAQLDPNLPC-----LHTQDFEPCMGPGC--SEEE------------- 494

  Fly   479 PSSGSMAECQLTNWGEWSPCTKTCGRGSSTRTRDYYN--PQARQRCLSVMRIPLEETRECIGSDC 541
                 .:.|.::.|..||||:.:||.|..:|.| |..  |:....|    .:|.|||.:|:.:|
Zfish   495 -----ASTCMMSEWISWSPCSASCGMGMRSRER-YVKQFPEDGSSC----TLPTEETEKCVVND- 548

  Fly   542 GGTIPDNGELDGFPEPDVFGETDHGGYMGKTTSWNSKQEHS-SLGSGNQAWNR------------ 593
                      |..|...|            .|.|...:..| |.|.|.:...|
Zfish   549 ----------DCSPSSCV------------VTEWGEWEPCSVSCGLGMRRRERMMKMDASDGSPC 591

  Fly   594 ----------------------KPYNSWKDKSLS-----NPRDNAQESPNLP------FDQIENP 625
                                  .|::.|.:.|:|     ..|....::|..|      .:|:|..
Zfish   592 RVQMAEAEKCMMPECNAVVCMLSPWSDWGECSVSCGVGMRTRQRMLKTPVKPGQCPDELEQVEKC 656

  Fly   626 QRPAYNPSDNM 636
            ..|.. |:|.|
Zfish   657 MLPEC-PTDCM 666

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG30203	NP_725128.2	Reeler	18..160	CDD:260081	51/141 (36%)
		Spond_N	183..372	CDD:283999	75/194 (39%)
		TSP1	411..459	CDD:214559	16/51 (31%)
		TSP1	492..541	CDD:214559	18/50 (36%)
		KU	<739..773	CDD:197529
spon1b	XP_005174403.1	Reeler	50..179	CDD:260081	49/130 (38%)
		Spond_N	200..387	CDD:283999	76/195 (39%)
		TSP_1	442..490	CDD:278517	16/52 (31%)
		TSP_1	501..546	CDD:278517	18/49 (37%)
		TSP_1	558..606	CDD:278517	7/47 (15%)
		TSP_1	614..661	CDD:278517	10/46 (22%)
		TSP_1	668..716	CDD:278517
		TSP1	756..804	CDD:214559
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170574083
Domainoid	1	1.000	186	1.000	Domainoid score	I3283
eggNOG	1	0.900	-	-		E1_KOG3539
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	381	1.000	Inparanoid score	I2015
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D240419at33208
OrthoFinder	1	1.000	-	-		FOG0003147
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_104958
Panther	1	1.100	-	-	O	PTHR11311
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2543
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	11	10.760