DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG30203 and fat-spondin

DIOPT Version :9

Sequence 1:	NP_725128.2	Gene:	CG30203 / 246514	FlyBaseID:	FBgn0050203	Length:	924	Species:	Drosophila melanogaster
Sequence 2:	NP_477435.1	Gene:	fat-spondin / 36919	FlyBaseID:	FBgn0026721	Length:	763	Species:	Drosophila melanogaster

Alignment Length:	863	Identity:	256/863 - (29%)
Similarity:	370/863 - (42%)	Gaps:	174/863 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MLRHIVLLILLSSEVRGVCNRIPQGAS-GPRSPVDDNFKILIDGNPETYVPEHQYN-VSLSCPIN 63
            :|..::::|.|:..:...|.|.|...: |.|:..|:.:|:::...|..|||...|| :.|....:
  Fly     7 LLIRLIVVIWLTISMVTACPRAPTHLNHGRRTRGDNGYKLIVADGPNGYVPGKTYNLLLLGSRTH 71

  Fly    64 MK---FVSFTLVVEAED----PSAAFGGQDMTGHFELLGVGDTRFSTSCENMVENTNTNAKIYIA 121
            :|   |..||:..||..    |.||  .....|.|:|.....|:|:..|.|.|...:...|..:.
  Fly    72 LKVQHFTHFTITAEAHTGARRPQAA--SPRRVGRFQLFSDSLTQFNDRCVNTVSEADDLPKTEVQ 134

  Fly   122 VSWIAPRNPDSGCVLIKAGVVQHRDVWFLDDGFLTKRICPEEIDELNSLTPPLETCCACDEAKYE 186
            |.|:||.: .||||.:.|.|.:....||.|||.|:..||..:.|    .....:.|||||||||.
  Fly   135 VMWVAPES-GSGCVSLSAMVYEGPRAWFADDGNLSTVICERKPD----AAAAQKECCACDEAKYS 194

  Fly   187 IVLERKWARNTHWKDFPSEDWRTRLGEVIGASHSHSYRYWAYGGRASKGMKELAEHGATRTLENE 251
            .|.|..|:..||.||:|...|.|...:||||||..::.:|.....|:.|.:.|||.|:...||.|
  Fly   195 FVFEGIWSNETHPKDYPFAIWLTHFSDVIGASHESNFSFWGENHIATAGFRSLAEWGSPAALETE 259

  Fly   252 IRENTQNGEVRTIIKAPGIPYRPKTFGTTLANARLDPVHHQISLAAKIDPSPDWILGVAGLELCL 316
            :|.|  ..::||:|||.|:.| |.....|.:..|:|..|.::||.:...|||||::|::||:||.
  Fly   260 LRAN--GPKLRTLIKAAGLWY-PNVNQNTSSKFRVDRKHPKVSLVSMFGPSPDWVVGISGLDLCT 321

  Fly   317 SNCTWLERKVLNLYPWDIGTDSGPSYMSSDEPQVPPDVVRRITSSYPSDHRSPFYDDTGAPMKPL 381
            .:|:|.|....:|:|||.|||||.||||.:....||:.:.|||:.||.|.|:|||:.....|.||
  Fly   322 EDCSWKESMDFDLFPWDAGTDSGISYMSPNSETQPPERMYRITTMYPEDPRAPFYNPKSREMTPL 386

  Fly   382 ATLYLTRKKLYIRECEE--------------VPQEGPLECAVHPWNEWTNCSTRCGQGYSHRQRS 432
            |.|||.|:|:..|.|::              ..|:...||.|..::.|:.||..||:|...|.|.
  Fly   387 AKLYLRREKIVSRNCDDEFLQALQLEVSDDAEEQDTRAECRVGDYSAWSPCSVSCGKGIRMRSRQ 451

  Fly   433 FKNPNLAANFNCDRRLEEFRQCQGT--QC--GAAEEELEGEEPGLGMENPPS-SGSMAE----CQ 488
            :..|..|....|.|:|.....|...  :|  |.|:.:...::.|..:.|..| .||..|    |:
  Fly   452 YLYPAAADQNKCARQLVAKEMCVAAIPECADGPAQSKDRDDDEGENLANSQSLVGSNGEGAGLCK 516

  Fly   489 LTNWGEWSPCTKTCGRGSSTRTRDYYNPQARQRCLSVMRIPLEETRECIGSDCGGTIPDNGELDG 553
            .:.|..||.|:.:||.|.:.|||.:.|...|:||   ..|.:.|..:|:..||      ..|...
  Fly   517 TSPWSVWSECSASCGIGITMRTRTFVNHLGRKRC---PHITIVEKNKCMRPDC------TYEQVE 572

  Fly   554 FPEPDVFGETDHGGYMGKTTSWNSKQEHSSLGSGNQAWNRKPYNSWKDKSLSNPRDNAQESPNLP 618
            .|:|..                                   |.:.|.|
  Fly   573 LPDPQC-----------------------------------PTSQWSD----------------- 585

  Fly   619 FDQIENPQRPAYNPSDNMGGYDKGFPPTNSYSNDKLVGNRPGYNDFNSDYNNKDAYNDYTTPSFT 683
                       ::|..:..|  :|   ....:...|:.|.|          :|:        |.|
  Fly   586 -----------WSPCSSTCG--RG---VTIRTRLLLLENGP----------DKE--------SCT 616

  Fly   684 SRTPFGSRYPNQQETVEGNTNDINGNYNVVQDYCFEKPYASTLPCFAKPVVESNY--WFYDHEDH 746
            .|    .....|:|.|  |..|.:.|....:|.|.:.|...  ||      ...|  :.||.::.
  Fly   617 QR----MELHQQKECV--NPIDCHINAEQAKDICVQAPDPG--PC------RGTYMRYAYDPQNQ 667

  Fly   747 ECKIFTTDNCDQNRNRFRTLTACEGTCLQPQINMERSENDAMDLYGRRSYDQKQ-------TRGR 804
            .|..||...|..|||.|.|...|..||     |:.||.      |..| .||.:       :...
  Fly   668 HCYSFTYGGCRGNRNNFLTENDCLNTC-----NVLRSP------YSSR-VDQPRACVLSDWSVWS 720

  Fly   805 PYDQTSGIAYGQTEGRSY 822
            |...:.|:  |.:|.|.|
  Fly   721 PCSVSCGV--GVSESRRY 736

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG30203	NP_725128.2	Reeler	18..160	CDD:260081	48/150 (32%)
		Spond_N	183..372	CDD:283999	82/188 (44%)
		TSP1	411..459	CDD:214559	14/49 (29%)
		TSP1	492..541	CDD:214559	17/48 (35%)
		KU	<739..773	CDD:197529	12/33 (36%)
fat-spondin	NP_477435.1	Reeler	24..172	CDD:260081	48/150 (32%)
		Spond_N	191..378	CDD:283999	83/189 (44%)
		TSP1	428..473	CDD:214559	14/44 (32%)
		TSP1	518..566	CDD:214559	17/50 (34%)
		TSP1	581..627	CDD:214559	13/100 (13%)
		Kunitz_BPTI	643..694	CDD:278443	17/58 (29%)
		TSP1	714..763	CDD:214559	6/25 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	186	1.000	Domainoid score	I3283
eggNOG	1	0.900	-	-		E1_KOG3539
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	381	1.000	Inparanoid score	I2015
Isobase	1	0.950	-	0	Normalized mean entropy	S5564
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D240419at33208
OrthoFinder	1	1.000	-	-		FOG0003147
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_104958
Panther	1	1.100	-	-	P	PTHR11311
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2543
	10	9.820