DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG18853 and Cry1

DIOPT Version :9

Sequence 1:	NP_724615.1	Gene:	CG18853 / 246511	FlyBaseID:	FBgn0042173	Length:	330	Species:	Drosophila melanogaster
Sequence 2:	NP_942045.2	Gene:	Cry1 / 299691	RGDID:	735083	Length:	588	Species:	Rattus norvegicus

Alignment Length:	190	Identity:	43/190 - (22%)
Similarity:	64/190 - (33%)	Gaps:	57/190 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   112 EKRAVPRQSIVGSRLRGIIQLNDGVFTNPE-HSLEGLEDFSHL----WLIYHFHRNNSHPKAKAD 171
            ||..||....:|....|   |:..|:...| .:|..||  .||    | :.:|.|    |:..|
  Rat   188 EKYGVPSLEELGFDTDG---LSSAVWPGGETEALTRLE--RHLERKAW-VANFER----PRMNA- 241

  Fly   172 NFCFYNEHYDSLKGLSSWA-----------YQTLDAHRKDKRDPCYSLEELEKSLTYDDLWNSAQ 225
                 |....|..|||.:.           ::..|.::|.|::....| .|...|.:.:.:.:|.
  Rat   242 -----NSLLASPTGLSPYLRFGCLSCRLFYFKLTDLYKKVKKNSSPPL-SLYGQLLWREFFYTAA 300

  Fly   226 LQLVREGKMHGFLRMYWAKKI---LEWTATPEHALEYAILLNDKYSLDGRDPNGYVGCMW 282
            ....|..||.|       ..|   :.|...||...::|              .|..|..|
  Rat   301 TNNPRFDKMEG-------NPICVQIPWDKNPEALAKWA--------------EGRTGFPW 339

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG18853	NP_724615.1	UPF0066	100..>163	CDD:294485	17/55 (31%)
Cry1	NP_942045.2	DNA_photolyase	5..167	CDD:279247
		PhrB	6..491	CDD:223492	43/190 (23%)
		LIR 1. /evidence=ECO:0000250\|UniProtKB:P97784	50..54
		LIR 2. /evidence=ECO:0000250\|UniProtKB:P97784	82..87
		LIR 3. /evidence=ECO:0000250\|UniProtKB:P97784	151..156
		FAD_binding_7	213..486	CDD:281440	35/162 (22%)
		LIR 4. /evidence=ECO:0000250\|UniProtKB:P97784	255..260		0/4 (0%)
		LIR 5. /evidence=ECO:0000250\|UniProtKB:P97784	271..276		1/4 (25%)
		LIR 6. /evidence=ECO:0000250\|UniProtKB:P97784	285..290		1/4 (25%)
		LIR 7. /evidence=ECO:0000250\|UniProtKB:P97784	335..339		1/3 (33%)
		Required for inhibition of CLOCK-ARNTL/BMAL1-mediated transcription. /evidence=ECO:0000250\|UniProtKB:P97784	371..470
		LIR 8. /evidence=ECO:0000250\|UniProtKB:P97784	379..384
		LIR 9. /evidence=ECO:0000250\|UniProtKB:P97784	395..400
		LIR 10. /evidence=ECO:0000250\|UniProtKB:P97784	411..416
		LIR 11. /evidence=ECO:0000250\|UniProtKB:P97784	430..435
		Interaction with TIMELESS. /evidence=ECO:0000250\|UniProtKB:P97784	471..493
		LIR 12. /evidence=ECO:0000250\|UniProtKB:P97784	486..491
		LIR 13. /evidence=ECO:0000250\|UniProtKB:P97784	492..497
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	511..588
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0415
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900