DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG30184 and pik3ca

DIOPT Version :9

Sequence 1:	NP_726341.1	Gene:	CG30184 / 246506	FlyBaseID:	FBgn0050184	Length:	223	Species:	Drosophila melanogaster
Sequence 2:	XP_009304451.1	Gene:	pik3ca / 561737	ZFINID:	ZDB-GENE-130409-1	Length:	1069	Species:	Danio rerio

Alignment Length:	262	Identity:	49/262 - (18%)
Similarity:	84/262 - (32%)	Gaps:	93/262 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 SKKPVW-----------FLFKMMEL-----------LLSLGCCLVHWTCFMEEGVPHIFLLCGTY 47
            :|:|:|           .||:..|:           :|:|....:....:..:|:....|   .|
Zfish   775 AKRPLWLNWENPDIMSELLFQNNEIIFKNGDDLRQDMLTLQIIRIMENIWQNQGLDLRML---PY 836

  Fly    48 GGSVIICFISLIGAFYAERPTMKHEALFGGILGGL--HMVTVY--------ANMYVATLEEFRTE 102
            |...|...:.||....:....|:.:.. ||:.|.|  :..|::        ..||...::.|..
Zfish   837 GCLSIGDCVGLIEVVRSSHTIMQIQCK-GGLKGALQFNSTTLHQWLKDKNKGEMYDMAIDLFTR- 899

  Fly   103 RWPSFYACCRDNAIVALYAGAIYLM-----HCT----------FALDLMFSHSRSRANQKMHPQR 152
                  :|       |.|..|.:::     |.:          |.:|  |.|......:|...:|
Zfish   900 ------SC-------AGYCVATFILGIGDRHNSNIMVKDDGQLFHID--FGHFLDHKKKKFGYKR 949

  Fly   153 SKRPLQ-----LYFISRGA------------------EAYLS---RFWFFRRIAARMLTSAQPSE 191
            .:.|..     |..||:|.                  :|||:   ....|..:.:.||.|..|..
Zfish   950 ERVPFVLTQDFLIVISKGGTQECTKTREFERFQEMCYKAYLAIRQHANLFINLFSMMLGSGMPEL 1014

  Fly   192 HS 193
            .|
Zfish  1015 QS 1016

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG30184	NP_726341.1	None
pik3ca	XP_009304451.1	PI3K_p85B	31..108	CDD:197539
		PI3K_rbd	173..292	CDD:307097
		C2_PI3K_class_I_alpha	325..484	CDD:176043
		PI3Ka_I	529..696	CDD:238444
		PKc_like	695..1065	CDD:328722	49/262 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5032
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900