DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG30184 and PIK3CA

DIOPT Version :9

Sequence 1:	NP_726341.1	Gene:	CG30184 / 246506	FlyBaseID:	FBgn0050184	Length:	223	Species:	Drosophila melanogaster
Sequence 2:	NP_006209.2	Gene:	PIK3CA / 5290	HGNCID:	8975	Length:	1068	Species:	Homo sapiens

Alignment Length:	263	Identity:	53/263 - (20%)
Similarity:	83/263 - (31%)	Gaps:	96/263 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 SKKPVW-----------FLFKMMEL-----------LLSLGCCLVHWTCFMEEGVPHIFLLCGTY 47
            :|:|:|           .||:..|:           :|:|....:....:..:|:....|   .|
Human   775 AKRPLWLNWENPDIMSELLFQNNEIIFKNGDDLRQDMLTLQIIRIMENIWQNQGLDLRML---PY 836

  Fly    48 GGSVIICFISLIGAFYAERPTMKHEALFGGILGGLHMVTVYANMYVATLEEFRTERWPSFYACCR 112
            |...|...:.||.........|:.:.. ||:.|.|..     |.:  ||.:     |      .:
Human   837 GCLSIGDCVGLIEVVRNSHTIMQIQCK-GGLKGALQF-----NSH--TLHQ-----W------LK 882

  Fly   113 DNAIVALYAGAIYLM------HC--TFAL--------DLM-----------FSHSRSRANQKMHP 150
            |.....:|..||.|.      :|  ||.|        ::|           |.|......:|...
Human   883 DKNKGEIYDAAIDLFTRSCAGYCVATFILGIGDRHNSNIMVKDDGQLFHIDFGHFLDHKKKKFGY 947

  Fly   151 QRSKRPLQ-----LYFISRGAE-----------------AYLS---RFWFFRRIAARMLTSAQPS 190
            :|.:.|..     |..||:||:                 |||:   ....|..:.:.||.|..|.
Human   948 KRERVPFVLTQDFLIVISKGAQECTKTREFERFQEMCYKAYLAIRQHANLFINLFSMMLGSGMPE 1012

  Fly   191 EHS 193
            ..|
Human  1013 LQS 1015

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG30184	NP_726341.1	None
PIK3CA	NP_006209.2	PI3K_p85B	32..107	CDD:396665
		PI3K_rbd	173..292	CDD:197540
		C2_PI3K_class_I_alpha	325..484	CDD:176043
		PI3Ka_I	525..696	CDD:238444
		PI3Kc_IA_alpha	695..1064	CDD:270719	53/263 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5032
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900