| Sequence 1: | NP_726341.1 | Gene: | CG30184 / 246506 | FlyBaseID: | FBgn0050184 | Length: | 223 | Species: | Drosophila melanogaster |
|---|---|---|---|---|---|---|---|---|---|
| Sequence 2: | NP_001308307.1 | Gene: | PIK3C2A / 5286 | HGNCID: | 8971 | Length: | 1686 | Species: | Homo sapiens |
| Alignment Length: | 220 | Identity: | 43/220 - (19%) |
|---|---|---|---|
| Similarity: | 77/220 - (35%) | Gaps: | 47/220 - (21%) |
- Green bases have known domain annotations that are detailed below.
|
Fly 23 GCCLVHWTCFMEEGVPHIFLLCGTYGGSVII-----CFISLIGAFYAERPTMKHEALFGGILGGL 82
Fly 83 HMVTVYANM-YVATLEEFRTERWPSFY-ACCRDNAIVA----LYAGAIYLM------HCTFALDL 135
Fly 136 MFSHSRSRANQKMHPQRSKRPLQLYF---ISRGAEAYLSRFWFFRRIAARMLTSAQPSEHSGRKR 197
Fly 198 QVSSSESDSDAKEREEERIRNSEVF 222 |
| Gene | Sequence | Domain | Region | External ID | Identity |
|---|---|---|---|---|---|
| CG30184 | NP_726341.1 | None | |||
| PIK3C2A | NP_001308307.1 | Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 1..61 | ||
| Interaction with clathrin, sufficient to induce clathrin assembly. /evidence=ECO:0000269|PubMed:16215232 | 2..142 | ||||
| Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 348..367 | ||||
| PI3K_rbd | 409..512 | CDD:279173 | |||
| Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 618..639 | ||||
| C2A_PI3K_class_II | 677..849 | CDD:175979 | |||
| PI3Ka_II | 870..1038 | CDD:238441 | |||
| PI3Kc_C2_alpha | 1043..1395 | CDD:270720 | 32/178 (18%) | ||
| PX_PI3K_C2_alpha | 1426..1534 | CDD:132822 | 2/5 (40%) | ||
| Interaction with PtdIns(4,5)P2-containing membranes. /evidence=ECO:0000250|UniProtKB:Q61194 | 1488..1493 | ||||
| C2B_PI3K_class_II | 1560..1681 | CDD:176027 | |||
| Nuclear localization signal. /evidence=ECO:0000269|PubMed:11606566 | 1608..1619 | ||||
| Blue background indicates that the domain is not in the aligned region. | |||||
| Tool | Simple Score | Weighted Score | Original Tool Information | |||
|---|---|---|---|---|---|---|
| BLAST Result | Score | Score Type | Cluster ID | |||
| Compara | 0 | 0.000 | Not matched by this tool. | |||
| Domainoid | 0 | 0.000 | Not matched by this tool. | |||
| eggNOG | 1 | 0.900 | - | - | E1_COG5032 | |
| Hieranoid | 0 | 0.000 | Not matched by this tool. | |||
| Homologene | 0 | 0.000 | Not matched by this tool. | |||
| Inparanoid | 0 | 0.000 | Not matched by this tool. | |||
| Isobase | 0 | 0.000 | Not matched by this tool. | |||
| OMA | 0 | 0.000 | Not matched by this tool. | |||
| OrthoDB | 0 | 0.000 | Not matched by this tool. | |||
| OrthoFinder | 0 | 0.000 | Not matched by this tool. | |||
| OrthoInspector | 0 | 0.000 | Not matched by this tool. | |||
| orthoMCL | 0 | 0.000 | Not matched by this tool. | |||
| Panther | 0 | 0.000 | Not matched by this tool. | |||
| Phylome | 0 | 0.000 | Not matched by this tool. | |||
| RoundUp | 0 | 0.000 | Not matched by this tool. | |||
| SonicParanoid | 0 | 0.000 | Not matched by this tool. | |||
| SwiftOrtho | 0 | 0.000 | Not matched by this tool. | |||
| TreeFam | 0 | 0.000 | Not matched by this tool. | |||
| User_Submission | 0 | 0.000 | Not matched by this tool. | |||
| 1 | 0.900 | |||||