Protein Alignment ppk3 and ASIC3

DIOPT Version :9

• Sequence 1: NP_726336.1
• Gene: ppk3 / 246504
• FlyBaseID: FBgn0050181
• Length: 535
• Species: Drosophila melanogaster
• Sequence 2: NP_064717.1
• Gene: ASIC3 / 9311
• HGNCID: 101
• Length: 549
• Species: Homo sapiens
• Alignment Length: 560
• Identity: 115/560 - (20%)
• Similarity: 183/560 - (32%)
• Gaps: 131/560 - (23%)

  Fly    31 GCGRLFGRLRDVVAQAGAETGLLALSLCVNRSIHLLERLFWLAVVVSSVIAAL--VLSRLQLERY 93
            |.|.:||            .|.|:           |.|..|.|.||.||...|  |..|::..|.
Human    28 GLGHVFG------------PGSLS-----------LRRGMWAAAVVLSVATFLYQVAERVRYYRE 69

  Fly    94 FSSPTVISVDRDYRGWNGSLPAVTLCYYDHIDSFKANEYIQEMWNVSIIDEDYFYFMDFLYAVVN 158
            |...|.:.....:|   ...||||||..:.:...:...........:::..|......||.|:
Human    70 FHHQTALDERESHR---LIFPAVTLCNINPLRRSRLTPNDLHWAGSALLGLDPAEHAAFLRAL-- 129

  Fly   159 ATAGNYAELAKFAEDERFDQIDLYEMIQRVDRPFEQVISSFDAGFQ------VHVQRVMTERGAC 217
               |.......|.....||...||   .|.....:.::  .|..|:      .:...:.|..|.|
Human   130 ---GRPPAPPGFMPSPTFDMAQLY---ARAGHSLDDML--LDCRFRGQPCGPENFTTIFTRMGKC 186

  Fly   218 YAINSP------MSTVLSGQPVAYELMPQPLSCQYGKQQCYIRM--DLYESTGVLDVHSPFEVSA 274
            |..||.      ::|...|.....::|   |..|   |:.|:.:  |..|        :||||..
Human   187 YTFNSGADGAELLTTTRGGMGNGLDIM---LDVQ---QEEYLPVWRDNEE--------TPFEVGI 237

  Fly   275 TEANIVALHKSDE----------ITASFKVLETVASKNLRQLSVAQRKC---------------V 314
            .    |.:|..:|          ::..::...:...:.|..|......|               .
Human   238 R----VQIHSQEEPPIIDQLGLGVSPGYQTFVSCQQQQLSFLPPPWGDCSSASLNPNYEPEPSDP 298

  Fly   315 FNNEETSNLKIYSKSLCLARCRAVMALEMCNCVPFFYPYVDGPSCNPAGFE-CLLDFKWPIWALH 378
            ..:...|....|:...|...|........|.|...:.| .|.|.|:|..:: |.......:....
Human   299 LGSPSPSPSPPYTLMGCRLACETRYVARKCGCRMVYMP-GDVPVCSPQQYKNCAHPAIDAMLRKD 362

  Fly   379 ICKCPSTCTEIEYT--MQTVKKSSWGVK-------NNEE--VASSETATSSFRWDLIPPKVRMRR 432
            .|.||:.|....|.  :..|:..|....       |..|  :|.:..|...|...|....|..::
Human   363 SCACPNPCASTRYAKELSMVRIPSRAAARFLARKLNRSEAYIAENVLALDIFFEALNYETVEQKK 427

  Fly   433 DVVYSFEDLVVSFGGVLALFVGVSVMGLVEMVHVLVNNLLLDVFTLLRLMLGRLRRCWRRDDHMR 497
              .|...:|:...||.:.||:|.|::.::|::     :.|.:||.  ..:||..   |.|....|
Human   428 --AYEMSELLGDIGGQMGLFIGASLLTILEIL-----DYLCEVFR--DKVLGYF---WNRQHSQR 480

  Fly   498 EANHH-------HHANAHAHARLHDFNERLSLAATAELPP 530
            .::.:       .|.....|..|..    .:|..:.:|||
Human   481 HSSTNLLQEGLGSHRTQVPHLSLGP----STLLCSEDLPP 516

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ppk3	NP_726336.1	ASC	59..464	CDD:279230	94/457 (21%)
ASIC3	NP_064717.1	ASC	20..534	CDD:295594	115/560 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	285..307		1/21 (5%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4294
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D303969at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820