DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ppk3 and asic1a

DIOPT Version :9

Sequence 1:	NP_726336.1	Gene:	ppk3 / 246504	FlyBaseID:	FBgn0050181	Length:	535	Species:	Drosophila melanogaster
Sequence 2:	XP_021333995.1	Gene:	asic1a / 791696	ZFINID:	ZDB-GENE-040513-2	Length:	614	Species:	Danio rerio

Alignment Length:	530	Identity:	112/530 - (21%)
Similarity:	178/530 - (33%)	Gaps:	136/530 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    62 SIHLLERLF-----------WLAVVVSSVIAALVLSRLQLERYFSSPTVISVDRDYRGWNGSLPA 115
            ::|.:..:|           |:...:||:...:.:...:::.|...|.|..:| :........||
Zfish   144 TLHGISHIFSYEKITAKCCLWVVFFLSSLTFLMYVCIDRIQFYLEYPHVTKLD-EITTPVMVFPA 207

  Fly   116 VTLCYYDHI--------DSFKANEYI------QEMWNVSIIDEDYFYFMDFLYAVVNATAGNYAE 166
            ||:|..:.|        |.:.|.|.:      .|:....:::|                  :..|
Zfish   208 VTICNLNSIRFSRITRNDLYHAGELLALLNSRHEVREAHLVEE------------------SVME 254

  Fly   167 LAKFAEDERF---DQIDLYEMIQRVDRPFEQVISSFD--------AGFQVHVQRVMTERGACYAI 220
            :.|...|.|.   ...:::|...|.....:.::.|..        ..|.|    |.|..|.||..
Zfish   255 VLKSKTDFRSFKPRHFNMWEFYNRTGHDIKDMLLSCQFRGSPCRPEDFSV----VFTRYGKCYTF 315

  Fly   221 NS-----PMSTVLSGQPVAYELMPQPLSCQYGKQQCYIRMDLYESTGVLDVHSPFEVSATEANI- 279
            ||     |..:|..|.....|:|..            |:.|.|     |.|....:.|:.||.|
Zfish   316 NSGETGPPRVSVKGGMGNGLEIMLD------------IQQDEY-----LPVWGESDESSFEAGIK 363

  Fly   280 VALHKSDE----------ITASFKVLETVASKNLRQLSVAQRKCVFNNEETSNLKIYSKSLCLAR 334
            |.:|..||          :...|:...:...:.|..|......|......:...:.||.|.|...
Zfish   364 VQIHSQDEPPFIDQLGFGVAPGFQTFVSCQEQRLVYLPAPWGSCKSTPPSSDYFRAYSISACRTD 428

  Fly   335 CRAVMALEMCNCVPFFYPYVDGPSCNPAGF-EC---LLDFKWPIWALHICKCPSTCTEIEYTMQ- 394
            |.....:|.|||.....| .|.|.|.|..: ||   .|||.....: ..|.|.:.|....|:.:
Zfish   429 CETRYLVENCNCRMVHMP-GDAPYCTPVLYKECAHPALDFLVETDS-DYCSCETPCNITRYSKEL 491

  Fly   395 -------------TVKKSSWGVKNNEEVASSETATSSFRWDLIPPKVRMRRDVVYSFEDLVVSFG 446
                         ..||.|   |:.:.:..:......|...|....:..|:  .|....|:...|
Zfish   492 SFVKIPSKASVKYLAKKYS---KSEKYITENVMVLDVFFEALNYETIEQRK--AYEVAGLLGDIG 551

  Fly   447 GVLALFVGVSVMGLVEMVHVLVNNLLLDVFTLLRLMLGRLRRCWRRDDHMREANHHHHA------ 505
            |.:.||:|.|::.::|         |.|.  |..:|..||.||..:..|....|..|:|
Zfish   552 GQMGLFIGASILTILE---------LFDY--LYEVMKYRLCRCSNKKHHNNNNNTDHNAVFSLDD 605

  Fly   506 -NAHAHARLH 514
             |.|. ::.|
Zfish   606 VNCHV-SKFH 614

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ppk3	NP_726336.1	ASC	59..464	CDD:279230	97/471 (21%)
asic1a	XP_021333995.1	ASC	136..582	CDD:322155	103/495 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D303969at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.920