Protein Alignment ppk3 and Asic5

DIOPT Version :10

• Sequence 1: NP_726336.1
• Gene: ppk3 / 246504
• FlyBaseID: FBgn0050181
• Length: 535
• Species: Drosophila melanogaster
• Sequence 2: NP_071563.1
• Gene: Asic5 / 63866
• RGDID: 69295
• Length: 495
• Species: Rattus norvegicus
• Alignment Length: 485
• Identity: 101/485 - (20%)
• Similarity: 167/485 - (34%)
• Gaps: 129/485 - (26%)

  Fly    66 LERLFWLAVVVSSVIAALVLSRLQLERYFSSPTVISVDRDYRGWNGSLPAVTLCYYDHIDSFKAN 130
            :.::.||:||:.||...:.....:|..||..||..|::..|.. ....||||.|..:...:...:
  Rat    60 VRKVIWLSVVLGSVSLLVWQIYSRLVNYFMWPTTTSIEVQYVE-KIEFPAVTFCNLNRFQTEAVS 123

  Fly   131 EYIQEMWNVSIIDEDYFYFMDFLYAV--VNATAGNYA---ELAKFAEDERFDQIDLYEMIQRVDR 190
            .:       .||    |:..|.:..|  :...:||..   |...|....|  ...:.|.::
  Rat   124 RF-------GII----FFLWDIVSKVLRLQEISGNNTGSPEALDFVASHR--NFSITEFVK---- 171

  Fly   191 PFEQVISSFDAGFQ------VHVQ------------RVMTERGACYAIN------SPMSTVLSGQ 231
                     :.||.      ||.:            .|.||.|.|:..|      |.....:||:
  Rat   172 ---------NNGFYLNHDTLVHCEFFGKTCDPKDFKHVFTEYGNCFTFNYGENVQSKNKVSVSGR 227

  Fly   232 PVAY-------ELMPQPLSCQYGKQQCYIRMDLYESTGVLDV-HSPFEVSATEANIVALHKSDEI 288
            .:..       |....|:..             :...||:.| |||    ..|.....|..|..:
  Rat   228 GLKLLLDVHQEEFTDNPVPG-------------FADAGVIFVIHSP----KKEPQFDGLGLSSPV 275

  Fly   289 TASFKVLETVASKNLRQLSVAQRKCVFN----NEETSNLKIYSKSLCLARCRAVMALEMCNCVPF 349
            ....:|       .:|||....::..:.    :.:..|...||...||..|:|.....:|.|:||
  Rat   276 GMHARV-------TIRQLKTIHQEYPWGECNPDIKLRNFTTYSTYGCLKECKAKHIQRLCGCLPF 333

  Fly   350 FYPYVDGPSCNPAGFECLLDFKW-----PI-----------WALHICKCPSTCTEIEY------- 391
            ..|        ..|.||.| .|:     ||           ...|...||..|.|.||
  Rat   334 LLP--------GNGVECDL-LKYYNCVSPILDHIERKGLCTMGTHNSSCPVPCEETEYPATIAYS 389

  Fly   392 ---TMQTVKKSSWGVKNNEEVASSETATSSFRWDLIPPKVRMRRDVVYSFEDLVVSFGGVLALFV 453
               :.:..|..:..:..::|............:..:..|:..::..| |..:|:...||.|.||.
  Rat   390 TFPSQRATKFLAKKLNQSQEYIRENLVNIEINYSDLNYKITQQQKAV-SVPELLADVGGQLGLFC 453

  Fly   454 GVSVMGLVEMVHVLVNNLL-LDVFTLLRLM 482
            |.|::.::|::..|..:.. :.:|.||:::
  Rat   454 GASLITIIEIIEYLFTSFYWVFIFFLLKIL 483

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ppk3	NP_726336.1	ASC	59..464	CDD:459966	97/464 (21%)
Asic5	NP_071563.1	Binds the plasma membrane and stabilizes the channel in the closed state. /evidence=ECO:0000269|PubMed:27679529	1..30
		ASC	41..466	CDD:459966	97/466 (21%)
		GAS motif, ion selectivity filter. /evidence=ECO:0000250|UniProtKB:P78348	454..456		1/1 (100%)