DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ppk3 and Asic5

DIOPT Version :9

Sequence 1:	NP_726336.1	Gene:	ppk3 / 246504	FlyBaseID:	FBgn0050181	Length:	535	Species:	Drosophila melanogaster
Sequence 2:	NP_071563.1	Gene:	Asic5 / 63866	RGDID:	69295	Length:	495	Species:	Rattus norvegicus

Alignment Length:	485	Identity:	101/485 - (20%)
Similarity:	167/485 - (34%)	Gaps:	129/485 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    66 LERLFWLAVVVSSVIAALVLSRLQLERYFSSPTVISVDRDYRGWNGSLPAVTLCYYDHIDSFKAN 130
            :.::.||:||:.||...:.....:|..||..||..|::..|.. ....||||.|..:...:...:
  Rat    60 VRKVIWLSVVLGSVSLLVWQIYSRLVNYFMWPTTTSIEVQYVE-KIEFPAVTFCNLNRFQTEAVS 123

  Fly   131 EYIQEMWNVSIIDEDYFYFMDFLYAV--VNATAGNYA---ELAKFAEDERFDQIDLYEMIQRVDR 190
            .:       .||    |:..|.:..|  :...:||..   |...|....|  ...:.|.::
  Rat   124 RF-------GII----FFLWDIVSKVLRLQEISGNNTGSPEALDFVASHR--NFSITEFVK---- 171

  Fly   191 PFEQVISSFDAGFQ------VHVQ------------RVMTERGACYAIN------SPMSTVLSGQ 231
                     :.||.      ||.:            .|.||.|.|:..|      |.....:||:
  Rat   172 ---------NNGFYLNHDTLVHCEFFGKTCDPKDFKHVFTEYGNCFTFNYGENVQSKNKVSVSGR 227

  Fly   232 PVAY-------ELMPQPLSCQYGKQQCYIRMDLYESTGVLDV-HSPFEVSATEANIVALHKSDEI 288
            .:..       |....|:..             :...||:.| |||    ..|.....|..|..:
  Rat   228 GLKLLLDVHQEEFTDNPVPG-------------FADAGVIFVIHSP----KKEPQFDGLGLSSPV 275

  Fly   289 TASFKVLETVASKNLRQLSVAQRKCVFN----NEETSNLKIYSKSLCLARCRAVMALEMCNCVPF 349
            ....:|       .:|||....::..:.    :.:..|...||...||..|:|.....:|.|:||
  Rat   276 GMHARV-------TIRQLKTIHQEYPWGECNPDIKLRNFTTYSTYGCLKECKAKHIQRLCGCLPF 333

  Fly   350 FYPYVDGPSCNPAGFECLLDFKW-----PI-----------WALHICKCPSTCTEIEY------- 391
            ..|        ..|.||.| .|:     ||           ...|...||..|.|.||
  Rat   334 LLP--------GNGVECDL-LKYYNCVSPILDHIERKGLCTMGTHNSSCPVPCEETEYPATIAYS 389

  Fly   392 ---TMQTVKKSSWGVKNNEEVASSETATSSFRWDLIPPKVRMRRDVVYSFEDLVVSFGGVLALFV 453
               :.:..|..:..:..::|............:..:..|:..::..| |..:|:...||.|.||.
  Rat   390 TFPSQRATKFLAKKLNQSQEYIRENLVNIEINYSDLNYKITQQQKAV-SVPELLADVGGQLGLFC 453

  Fly   454 GVSVMGLVEMVHVLVNNLL-LDVFTLLRLM 482
            |.|::.::|::..|..:.. :.:|.||:::
  Rat   454 GASLITIIEIIEYLFTSFYWVFIFFLLKIL 483

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ppk3	NP_726336.1	ASC	59..464	CDD:279230	97/464 (21%)
Asic5	NP_071563.1	deg-1	40..465	CDD:273309	97/465 (21%)
Asic5	NP_071563.1	ASC	41..466	CDD:279230	97/466 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4294
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D303969at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11690
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.920