Protein Alignment ppk3 and SCNN1G

DIOPT Version :9

• Sequence 1: NP_726336.1
• Gene: ppk3 / 246504
• FlyBaseID: FBgn0050181
• Length: 535
• Species: Drosophila melanogaster
• Sequence 2: NP_001030.2
• Gene: SCNN1G / 6340
• HGNCID: 10602
• Length: 649
• Species: Homo sapiens
• Alignment Length: 599
• Identity: 119/599 - (19%)
• Similarity: 197/599 - (32%)
• Gaps: 227/599 - (37%)

  Fly    58 CVNRSIH----------LLERLFWLAVVVSSVIAALVLSRLQLERYFSSPTV-ISVDRDYRGWNG 111
            |:|.:.|          .|.||.|:...:::|  ||:|.:..| ..||..|| :|:...:|..:
Human    33 CLNTNTHGCRRIVVSRGRLRRLLWIGFTLTAV--ALILWQCAL-LVFSFYTVSVSIKVHFRKLD- 93

  Fly   112 SLPAVTLC---------------------------YYDHIDSFKANEYIQEMWN----------- 138
             .||||:|                           .|...:|.|..|  .|.||
Human    94 -FPAVTICNINPYKYSTVRHLLADLEQETREALKSLYGFPESRKRRE--AESWNSVSEGKQPRFS 155

  Fly   139 ----VSIIDED-YFYFMDFLYAVVNATAGNYAELAKFAEDERFDQIDLYEMIQR-----VDRPFE 193
                :.|.|:| .....||.........|:....|.........|:..:::...     ....|.
Human   156 HRIPLLIFDQDEKGKARDFFTGRKRKVGGSIIHKASNVMHIESKQVVGFQLCSNDTSDCATYTFS 220

  Fly   194 QVISSFDAGFQVHVQRVMTE---------------------------------------RGACYA 219
            ..|::....:::|...:|.:                                       .|.||.
Human   221 SGINAIQEWYKLHYMNIMAQVPLEKKINMSYSAEELLVTCFFDGVSCDARNFTLFHHPMHGNCYT 285

  Fly   220 INSP-----MSTVLSGQPVAYELMPQPLSCQYGKQQ-CYIRMDLYESTGVLDVHSPFEVSATEAN 278
            .|:.     :||.:.|.             :||.|. .||..:.|         :||.||:|.|.
Human   286 FNNRENETILSTSMGGS-------------EYGLQVILYINEEEY---------NPFLVSSTGAK 328

  Fly   279 IVALHKSDE----------------------ITASFKVLETVASKNLRQLSVAQRKCVFNNEETS 321
            :: :|:.||                      :|.|||            ||....:|   .|:.|
Human   329 VI-IHRQDEYPFVEDVGTEIETAMVTSIGMHLTESFK------------LSEPYSQC---TEDGS 377

  Fly   322 NLKI-------YSKSLCLARCRAVMALEMCNCVPFFYPYVDGPSCNPAGFECLLDFKWPIWALHI 379
            ::.|       ||..:||..|.....:|.|.|..:..|.  .|:.|...::...::.:..:.||.
Human   378 DVPIRNIYNAAYSLQICLHSCFQTKMVEKCGCAQYSQPL--PPAANYCNYQQHPNWMYCYYQLHR 440

  Fly   380 --------CK--CPSTCTEIEYTMQTVKKSSWGVKNNEEVASSETATSSFRWD------------ 422
                    |:  |...|:..|:|: |...:.|     ..|.|.:.......||
Human   441 AFVQEELGCQSVCKEACSFKEWTL-TTSLAQW-----PSVVSEKWLLPVLTWDQGRQVNKKLNKT 499

  Fly   423 -----LIPPKVRMRRDVV----YSFEDLVVSFGGVLALFVGVSVMGLVEMVHVLVNNLLLDVFTL 478
                 ||..|...:|.::    .|.|.|:.:|||.|.|::..||:.::|::.|    ..:|.|::
Human   500 DLAKLLIFYKDLNQRSIMESPANSIEMLLSNFGGQLGLWMSCSVVCVIEIIEV----FFIDFFSI 560

  Fly   479 LRLMLGRLRRCWRR 492
            :      .||.|::
Human   561 I------ARRQWQK 568

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ppk3	NP_726336.1	ASC	59..464	CDD:279230	112/568 (20%)
SCNN1G	NP_001030.2	ENaC	24..630	CDD:273304	119/599 (20%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4294
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D303969at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820