DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ppk3 and SCNN1D

DIOPT Version :9

Sequence 1:	NP_726336.1	Gene:	ppk3 / 246504	FlyBaseID:	FBgn0050181	Length:	535	Species:	Drosophila melanogaster
Sequence 2:	NP_001123885.2	Gene:	SCNN1D / 6339	HGNCID:	10601	Length:	802	Species:	Homo sapiens

Alignment Length:	569	Identity:	125/569 - (21%)
Similarity:	205/569 - (36%)	Gaps:	168/569 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    47 GAETGLLALS---------LCVNRSIHLLERLF-----------WLAVVVSSVIAALVLSRLQLE 91
            |.:.||:.|.         .|.|.:||...||.           |..:.:.:::|......|..|
Human   208 GHQEGLVELPASFRELLTFFCTNATIHGAIRLVCSRGNRLKTTSWGLLSLGALVALCWQLGLLFE 272

  Fly    92 RYFSSPTVISVDRDYRGWNGSLPAVTLC------------YYDHIDSFKANEYIQEMWNVSII-- 142
            |::..|.:::|  ........||.||||            :.:.:|.| |.|.|..::||::.
Human   273 RHWHRPVLMAV--SVHSERKLLPLVTLCDGNPRRPSPVLRHLELLDEF-ARENIDSLYNVNLSKG 334

  Fly   143 ----------DEDYFYF---------------MDFLYAVVNATAGN-----YAELAKFAED-ERF 176
                      .|..|:.               :...:.:.|:|.|:     |.......:| ..|
Human   335 RAALSATVPRHEPPFHLDREIRLQRLSHSGSRVRVGFRLCNSTGGDCFYRGYTSGVAAVQDWYHF 399

  Fly   177 DQIDLYEMIQRV--------DRPFEQVIS-SFDAGFQVHVQRVMT----ERGACYAINSPMST-- 226
            ..:|:..::...        |..|  |:| |:| |.....::..|    ..|:||.::...:.
Human   400 HYVDILALLPAAWEDSHGSQDGHF--VLSCSYD-GLDCQARQFRTFHHPTYGSCYTVDGVWTAQR 461

  Fly   227 --VLSGQPVAYELMPQP----LSCQYGKQQCYIRMDLY--ESTGVLDVHSPFEV-SATEANIVAL 282
              :..|..:...:..||    ||...|     ||:.::  ..|..|..|| |.| ..|||.|..
Human   462 PGITHGVGLVLRVEQQPHLPLLSTLAG-----IRVMVHGRNHTPFLGHHS-FSVRPGTEATISI- 519

  Fly   283 HKSDEITASFKVLETVASKNLRQLSVAQRKCVFNNE----ETSNLKIYSKSLCLARCRAVMALEM 343
             :.||:               .:|......|....|    |..:...|::..||..|...:.:|.
Human   520 -REDEV---------------HRLGSPYGHCTAGGEGVEVELLHNTSYTRQACLVSCFQQLMVET 568

  Fly   344 CNCVPFFYPYVDGPSCNPAGFECLLDFKWPIWALHI--------------C--KCPSTCTEIEYT 392
            |:|..:.:|.       |||.|.....:.|.|. |.              |  :||..|.|..:.
Human   569 CSCGYYLHPL-------PAGAEYCSSARHPAWG-HCFYRLYQDLETHRLPCTSRCPRPCRESAFK 625

  Fly   393 MQT-------VKKSSWGVKNNEEVA----SSETATSSFRWDLIPPKVRMR---RDVVYSFEDLVV 443
            :.|       .|.:.|.:....|..    |....:|..:.:::..::..|   ...|||...|:.
Human   626 LSTGTSRWPSAKSAGWTLATLGEQGLPHQSHRQRSSLAKINIVYQELNYRSVEEAPVYSVPQLLS 690

  Fly   444 SFGGVLALFVGVSVMGLVEMVHVLVNNLLLDVFTLLRLMLG--RLRRCW 490
            :.|.:.:|:.|.||:.|:|::     .||||. :.|.|:||  ||||.|
Human   691 AMGSLCSLWFGASVLSLLELL-----ELLLDA-SALTLVLGGRRLRRAW 733

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ppk3	NP_726336.1	ASC	59..464	CDD:279230	107/518 (21%)
SCNN1D	NP_001123885.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	145..211		1/2 (50%)
		ENaC	219..784	CDD:273304	121/558 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	738..777
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4294
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D303969at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820