Protein Alignment ppk3 and SCNN1B

DIOPT Version :10

• Sequence 1: NP_726336.1
• Gene: ppk3 / 246504
• FlyBaseID: FBgn0050181
• Length: 535
• Species: Drosophila melanogaster
• Sequence 2: XP_016879014.1
• Gene: SCNN1B / 6338
• HGNCID: 10600
• Length: 659
• Species: Homo sapiens
• Alignment Length: 507
• Identity: 99/507 - (19%)
• Similarity: 178/507 - (35%)
• Gaps: 121/507 - (23%)

  Fly    54 ALSLC------VNRSIHLLERLFWLAVVVSSVIAALVLSRLQLERYFS------SPTVISVDRDY 106
            |:::|      .::..|||:.|..|...|...|.|..||.....|..:      :|.|:..:|
Human   113 AVTICNASPFKYSKIKHLLKDLDELMEAVLERILAPELSHANATRNLNFSIWNHTPLVLIDER-- 175

  Fly   107 RGWNGSLPAVTLCYYDHIDSFKANEYIQEMWN---------VSIIDEDYFYFMDFLYAVVNATAG 162
               |...|.|...:.|:.:...::...:::.|         :..::.....|.:|..|....|..
Human   176 ---NPHHPMVLDLFGDNHNGLTSSSASEKICNAHGCKMAMRLCSLNRTQCTFRNFTSATQALTEW 237

  Fly   163 NYAELAKFAEDERFDQIDLYEMIQRVDRPFEQVI------------SSFDAGFQVHVQRVMTERG 215
            ...:....     |.|:...|::: :..|.||:|            .:|.:.|..|.       |
Human   238 YILQATNI-----FAQVPQQELVE-MSYPGEQMILACLFGAEPCNYRNFTSIFYPHY-------G 289

  Fly   216 ACYAINSPMS--TVLSGQPVAYELMPQPLSCQYGKQQCYIRMDLYESTGVLDV----HSPFEVSA 274
            .||..|..|:  .:.|..|          ..::|.:.            :||:    :.||..|.
Human   290 NCYIFNWGMTEKALPSANP----------GTEFGLKL------------ILDIGQEDYVPFLAST 332

  Fly   275 TEANIVALHKS-------DEITASFKVLET---VASKNLRQLSVAQRKCVFNNEETSNLKIYSK- 328
            ....:: ||:.       ||...:....||   |....|:::......|..|..|......||.
Human   333 AGVRLM-LHEQRSYPFIRDEGIYAMSGTETSIGVLVDKLQRMGEPYSPCTVNGSEVPVQNFYSDY 396

  Fly   329 ------SLCLARCRAVMALEMCNCVPFFYPYVDGPS-CNPAGF----ECLLDFKWPIWALHIC-- 380
                  ..||..|.....:..|||..:.||...|.. ||...|    .|..|.:..:.....|
Human   397 NTTYSIQACLRSCFQDHMIRNCNCGHYLYPLPRGEKYCNNRDFPDWAHCYSDLQMSVAQRETCIG 461

  Fly   381 KCPSTCTEIEYTMQTVKKSSWGVKNNEE----VASSE----TATSSFRWDLIPPKVRMRRDVVYS 437
            .|..:|.:.:|.| |:..:.|..:.:|:    |.|.|    |..:..|..::...:..:.....:
Human   462 MCKESCNDTQYKM-TISMADWPSEASEDWIFHVLSQERDQSTNITLSRKGIVKLNIYFQEFNYRT 525

  Fly   438 FED--------LVVSFGGVLALFVGVSVMGLVEMVHVLVNNLLLDVFTLLRL 481
            .|:        |:.:.||....::|.||:.|:|...::::.:.:.:..|:.|
Human   526 IEESAANNIVWLLSNLGGQFGFWMGGSVLCLIEFGEIIIDFVWITIIKLVAL 577

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ppk3	NP_726336.1	ASC	59..464	CDD:459966	95/477 (20%)
SCNN1B	XP_016879014.1	ENaC	40..642	CDD:273304	99/507 (20%)