Protein Alignment ppk3 and SCNN1A

DIOPT Version :10

• Sequence 1: NP_726336.1
• Gene: ppk3 / 246504
• FlyBaseID: FBgn0050181
• Length: 535
• Species: Drosophila melanogaster
• Sequence 2: NP_001153048.1
• Gene: SCNN1A / 6337
• HGNCID: 10599
• Length: 728
• Species: Homo sapiens
• Alignment Length: 597
• Identity: 122/597 - (20%)
• Similarity: 194/597 - (32%)
• Gaps: 206/597 - (34%)

  Fly    16 RILRGLLALLWLILAGC-----GRLFGRLRDVVAQAGAETGLLALSLCVNRSIHL-LERLFWLAV 74
            |:.....|:|||...|.     |.|||..               .|..|:.:|:| .::|.:.||
Human   140 RMKTAFWAVLWLCTFGMMYWQFGLLFGEY---------------FSYPVSLNINLNSDKLVFPAV 189

  Fly    75 VVSSV-----------------IAALVLSRLQLERYFSSPTVISVDRDYRGWNGSLP-------- 114
            .:.::                 |....|  ..|.:|.|..|:::..|..|...|:||
Human   190 TICTLNPYRYPEIKEELEELDRITEQTL--FDLYKYSSFTTLVAGSRSRRDLRGTLPHPLQRLRV 252

  Fly   115 -------------------------------AVTLCYYDHIDSFKANEYIQEMWNVSIIDEDY-F 147
                                           ...||..:..|.|    |......|..:.|.| |
Human   253 PPPPHGARRARSVASSLRDNNPQVDWKDWKIGFQLCNQNKSDCF----YQTYSSGVDAVREWYRF 313

  Fly   148 YFMDFLY-------AVVNATAGNYAELAKFAEDERFDQIDLYEMIQRVDRPFEQVISSFDAGFQV 205
            ::::.|.       ::...|.||:.    ||  .||:|                 :|...|.:.
Human   314 HYINILSRLPETLPSLEEDTLGNFI----FA--CRFNQ-----------------VSCNQANYS- 354

  Fly   206 HVQRVMTERGACYAINSPMSTVL--SGQPVAYELMPQPLSCQYGKQQCYIRMDLYESTGVLDVHS 268
            |....|  .|.||..|...::.|  |..|.....:...|..:   |..:|
Human   355 HFHHPM--YGNCYTFNDKNNSNLWMSSMPGINNGLSLMLRAE---QNDFI--------------- 399

  Fly   269 PFEVSATEANIVALHKSDEITASFKVLETVASKNLR---QLSVAQRK------------CVFNNE 318
            |...:.|.|.:: :|..||     .........|||   :.|::.||            |..|..
Human   400 PLLSTVTGARVM-VHGQDE-----PAFMDDGGFNLRPGVETSISMRKETLDRLGGDYGDCTKNGS 458

  Fly   319 E--TSNL--KIYSKSLCLARCRAVMALEMCNCVPFFYP------YVDGPSCNPAGFECLLDFKWP 373
            :  ..||  ..|::.:|:..|.....::.|.|...|||      |.|....:..|: |....:..
Human   459 DVPVENLYPSKYTQQVCIHSCFQESMIKECGCAYIFYPRPQNVEYCDYRKHSSWGY-CYYKLQVD 522

  Fly   374 IWALHI-C--KCPSTCTEIEYTMQ-------TVKKSSW-----GVKNNEEVASSETATS------ 417
            ..:.|: |  ||...|:...|.:.       :|....|     ..:||..|.:.....:
Human   523 FSSDHLGCFTKCRKPCSVTSYQLSAGYSRWPSVTSQEWVFQMLSRQNNYTVNNKRNGVAKVNIFF 587

  Fly   418 ---SFRWDLIPPKVRMRRDVVYSFEDLVVSFGGVLALFVGVSVMGLVEMVHVLVNNLLLDVFTLL 479
               :::.:...|.|.|        ..|:.:.|...:|:.|.||:.:|||.. ||.:||:.:|.:|
Human   588 KELNYKTNSESPSVTM--------VTLLSNLGSQWSLWFGSSVLSVVEMAE-LVFDLLVIMFLML 643

  Fly   480 RLMLGRLR-RCW 490
               |.|.| |.|
Human   644 ---LRRFRSRYW 652

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ppk3	NP_726336.1	ASC	59..464	CDD:459966	99/520 (19%)
SCNN1A	NP_001153048.1	ENaC	113..706	CDD:273304	122/597 (20%)