Protein Alignment ppk3 and ASIC5

DIOPT Version :9

• Sequence 1: NP_726336.1
• Gene: ppk3 / 246504
• FlyBaseID: FBgn0050181
• Length: 535
• Species: Drosophila melanogaster
• Sequence 2: NP_059115.1
• Gene: ASIC5 / 51802
• HGNCID: 17537
• Length: 505
• Species: Homo sapiens
• Alignment Length: 536
• Identity: 114/536 - (21%)
• Similarity: 196/536 - (36%)
• Gaps: 166/536 - (30%)

  Fly    48 AETGLL-ALSLCVNR-----------------------SIH-------LLERLFWLAVVVSSVIA 81
            ||.||| .:.||:::                       .||       .:.|:.||.||:.||..
Human    11 AENGLLEKIKLCLSKKPLPSPTERKKFDHDFAISTSFHGIHNIVQNRSKIRRVLWLVVVLGSVSL 75

  Fly    82 ALVLSRLQLERYFSSPTVISVDRDYRGWNGSLPAVTLCYYDHIDSFKANEYIQEMWNVSIIDEDY 146
            ......::|..||:.||..|::..|.. ....||||.|   :::.|:.:...:
Human    76 VTWQIYIRLLNYFTWPTTTSIEVQYVE-KMEFPAVTFC---NLNRFQTDAVAK------------ 124

  Fly   147 FYFMDFLYAVVN---------ATAGNYAELAKFAEDERFDQIDLYEMIQRVDRPFEQVISSFDAG 202
            |..:.||:.:|:         |.:....|...||...:  ...:.|.|:             :.|
Human   125 FGVIFFLWHIVSKVLHLQEITANSTGSREATDFAASHQ--NFSIVEFIR-------------NKG 174

  Fly   203 FQVH------------------VQRVMTERGACYAINSPMSTVLSGQPVAYELMPQPLSCQYG-K 248
            |.::                  ...|.||.|.|:..|.. .|:.:.:.|:  :..:.||..:. .
Human   175 FYLNNSTLLDCEFFGKPCSPKDFAHVFTEYGNCFTFNHG-ETLQAKRKVS--VSGRGLSLLFNVN 236

  Fly   249 QQCYI---RMDLYESTGVLDVHSPFEVSATEA----NIVALHKSDEITASFKVLETVASKNLRQL 306
            |:.:.   .:...::..:..:|||.:|...:.    :.|.:|               |...:||:
Human   237 QEAFTDNPALGFVDAGIIFVIHSPKKVPQFDGLGLLSPVGMH---------------ARVTIRQV 286

  Fly   307 SVAQRKCVFN----NEETSNLKIYSKSLCLARCRAVMALEMCNCVPFFYP-YVDGPSCN-PAGFE 365
            ....::..:.    |.:..|...||.|.||..|:|....:.|.||||..| |  |..|: ...|.
Human   287 KTVHQEYPWGECNPNIKLQNFSSYSTSGCLKECKAQHIKKQCGCVPFLLPGY--GIECDLQKYFS 349

  Fly   366 CL------LDFKWPIWALHIC-------KCPSTCTEIEYTMQTVKKSSWGVKN------------ 405
            |:      ::||      .:|       .||.:|.||||. .|:..||:..:.
Human   350 CVSPVLDHIEFK------DLCTVGTHNSSCPVSCEEIEYP-ATISYSSFPSQKALKYLSKKLNQS 407

  Fly   406 ----NEEVASSETATSSFRWDLIPPKVRMRRDVVYSFEDLVVSFGGVLALFVGVSVMGLVEMVHV 466
                .|.:...|...|...:     |:..::..| |..:|:...||.|.||.|.|::.::|::..
Human   408 RKYIRENLVKIEINYSDLNY-----KITQQQKAV-SVSELLADLGGQLGLFCGASLITIIEIIEY 466

  Fly   467 LVNNLL-LDVFTLLRL 481
            |..|.. :.:|.||::
Human   467 LFTNFYWICIFFLLKI 482

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ppk3	NP_726336.1	ASC	59..464	CDD:279230	102/504 (20%)
ASIC5	NP_059115.1	ASC	41..466	CDD:279230	102/488 (21%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4294
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D303969at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11690
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.920