Protein Alignment ppk3 and ASIC1

DIOPT Version :9

• Sequence 1: NP_726336.1
• Gene: ppk3 / 246504
• FlyBaseID: FBgn0050181
• Length: 535
• Species: Drosophila melanogaster
• Sequence 2: NP_064423.2
• Gene: ASIC1 / 41
• HGNCID: 100
• Length: 574
• Species: Homo sapiens
• Alignment Length: 548
• Identity: 108/548 - (19%)
• Similarity: 173/548 - (31%)
• Gaps: 180/548 - (32%)

  Fly    37 GRLRDVVAQAGAETGLL-ALSLCVNRSIHLLERLFWLAVVVSSVIAALVLSRLQLERYFSSPTVI 100
            |.::.|..||.|.:..| .|:...:.....|:|..|....:.|:...|.:...:::.||....|.
Human    11 GGVQPVSIQAFASSSTLHGLAHIFSYERLSLKRALWALCFLGSLAVLLCVCTERVQYYFHYHHVT 75

  Fly   101 SVDRDYRGWNGSLPAVTLCYYDHIDSFKANEYIQEMWNVSIIDEDYFYFMDFLYAVVNATAGNYA 165
            .:| :......:.||||||        ..||:     ..|.:.::..|....|.|::|    |..
Human    76 KLD-EVAASQLTFPAVTLC--------NLNEF-----RFSQVSKNDLYHAGELLALLN----NRY 122

  Fly   166 EL--AKFAEDERFD--------------QIDLYEMIQRVDRPFE----------QVISSFDAGFQ 204
            |:  .:.|::::.:              ..::.|...|......          :|.|:.|  |:
Human   123 EIPDTQMADEKQLEILQDKANFRSFKPKPFNMREFYDRAGHDIRDMLLSCHFRGEVCSAED--FK 185

  Fly   205 VHVQRVMTERGACYAINS------PMSTVLSGQPVAYELMPQPLSCQYGKQQCYIRMDLYESTGV 263
            |    |.|..|.||..||      .:.|:..|.....|:|..            |:.|.|
Human   186 V----VFTRYGKCYTFNSGRDGRPRLKTMKGGTGNGLEIMLD------------IQQDEY----- 229

  Fly   264 LDVHSPFEVSATEANI-VALHKSDE----------ITASFKVLETVASKNLRQLSVAQRKC--VF 315
            |.|....:.::.||.| |.:|..||          :...|:.......:.|..|......|  |.
Human   230 LPVWGETDETSFEAGIKVQIHSQDEPPFIDQLGFGVAPGFQTFVACQEQRLIYLPPPWGTCKAVT 294

  Fly   316 NNEETSNLKIYSKSLCLARCRAVMALEMCNCVPFFYPYVDGPSCNPAGF-EC---LLDFKWPIWA 376
            .:.:......||.:.|...|.....:|.|||.....| .|.|.|.|..: ||   .|||
Human   295 MDSDLDFFDSYSITACRIDCETRYLVENCNCRMVHMP-GDAPYCTPEQYKECADPALDF------ 352

  Fly   377 L-----HICKCPSTC-----------------TEIEYTMQTVKKSSWGVKNN-------EEVASS 412
            |     ..|.|...|                 ...:|..:...||...:..|       .||.:.
Human   353 LVEKDQEYCVCEMPCNLTRYGKELSMVKIPSKASAKYLAKKFNKSEQYIGENILVLDIFFEVLNY 417

  Fly   413 ETATSSFRWDL-----------IP-------------------------------PKVRMRRDVV 435
            ||......:::           :|                               ||.....|:
Human   418 ETIEQKKAYEIAGLLGELLMTPVPFSCHGHGVAPYHPKAGCSLLSHEGPPPQRPFPKPCCLGDI- 481

  Fly   436 YSFEDLVVSFGGVLALFVGVSVMGLVEM 463
                      ||.:.||:|.|::.::|:
Human   482 ----------GGQMGLFIGASILTVLEL 499

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ppk3	NP_726336.1	ASC	59..464	CDD:279230	101/525 (19%)
ASIC1	NP_064423.2	ENaC	19..556	CDD:273304	106/540 (20%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4294
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D303969at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820