DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ppk3 and asic1b

DIOPT Version :9

Sequence 1:	NP_726336.1	Gene:	ppk3 / 246504	FlyBaseID:	FBgn0050181	Length:	535	Species:	Drosophila melanogaster
Sequence 2:	NP_999956.1	Gene:	asic1b / 407672	ZFINID:	ZDB-GENE-040513-1	Length:	557	Species:	Danio rerio

Alignment Length:	503	Identity:	104/503 - (20%)
Similarity:	170/503 - (33%)	Gaps:	127/503 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    51 GLLALSLCVNRSIHLLERLFWLAVVVSSVIAALVLSRLQLERYFSSPTVISVDRDYRGWNGSLPA 115
            ||.||...:..|:.||:       ||..||            |:.....:::..:....|.:.||
Zfish    93 GLWALVFLLAISMFLLQ-------VVDRVI------------YYLQYDYVTLLDERNAKNMTFPA 138

  Fly   116 VTLCYYDHIDSFKANEYIQEMWNVSIIDEDYFYFMDFLYAVVNATAGNYAELAKFAEDERFDQID 180
            :|||.|   ::|:.::         :...|..:....|....|...|  ..||. ..|.:..:..
Zfish   139 ITLCNY---NTFRRSQ---------LSYSDLLFMGPLLGYEDNMAPG--IPLAP-EPDRQGSRFS 188

  Fly   181 LYEMIQRV-----DRPFEQVISSFDAGFQVHVQRVMTERGACYAINSP------MSTVLSGQPVA 234
            |.|...|.     |...|...:..:.|.: |.:.:.|..|.||..||.      :.|...|....
Zfish   189 LAEFFNRTRHRMDDMLLECNFAGKECGAE-HWREIFTRYGKCYTFNSGQDGRPLLITTKGGMGNG 252

  Fly   235 YELMPQPLSCQYGKQQCYIRMDLYESTGVLDVHSPFEVSATEANI-VALHKSDE----------I 288
            .|:|..            |:.|.|     |.|....:.:..||.| |.:|..||          :
Zfish   253 LEIMLD------------IQQDEY-----LPVWGETDETTFEAGIKVQIHTQDEPPFIDQLGFGV 300

  Fly   289 TASFKVLETVASKNLRQLSVAQRKCVFNNEETSNLKIYSKSLCLARCRAVMALEMCNCVPFFYPY 353
            ...|:...:...:.|..|......|.....::.....||.:.|...|.....:|.|||.....|
Zfish   301 APGFQTFVSCQEQRLTYLPPPWGDCKATPIDSDFFNTYSITACRIDCETRYLVENCNCRMVHMP- 364

  Fly   354 VDGPSCNPAGF-EC---LLDFKWPIWAL-----HICKCPSTC-----------------TEIEYT 392
            .|.|.|.|..: ||   .|||      |     ..|.|.:.|                 ...:|.
Zfish   365 GDAPYCTPEQYKECADPALDF------LVERDNDYCVCETPCNMTRYGKELSFVRIPSKASAKYL 423

  Fly   393 MQTVKKSSWGVKNNEEVASSETATSSFRWDLIPPKVRMRRDVVYSFEDLVVSFGGVLALFVGVSV 457
            .:...|:...:.:|  :...:....:..::.|..|      ..|....|:...||.:.||:|.|:
Zfish   424 AKKYNKTEQYISDN--IMVLDIFFEALNYETIEQK------KAYELAGLLGDIGGQMGLFIGASI 480

  Fly   458 MGLVEMVHVLVNNLLLDVFTLLRLMLGRLRRCWRRDDHMREANHHHHA 505
            :.::|:...|        :.:::.   :|.||.:: .|.|..|:...|
Zfish   481 LTILELFDYL--------YEVIKF---KLCRCAKK-KHQRSNNNERGA 516

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ppk3	NP_726336.1	ASC	59..464	CDD:279230	92/452 (20%)
asic1b	NP_999956.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	36..57
		ASC	66..548	CDD:295594	104/503 (21%)
		Selectivity filter. /evidence=ECO:0000305	477..479		1/1 (100%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D303969at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.920