DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ppk3 and asic2

DIOPT Version :9

Sequence 1:	NP_726336.1	Gene:	ppk3 / 246504	FlyBaseID:	FBgn0050181	Length:	535	Species:	Drosophila melanogaster
Sequence 2:	XP_005164179.1	Gene:	asic2 / 407669	ZFINID:	ZDB-GENE-040513-4	Length:	564	Species:	Danio rerio

Alignment Length:	559	Identity:	120/559 - (21%)
Similarity:	193/559 - (34%)	Gaps:	142/559 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 WIRGAAARILRGLLALLWLILAGCGRLF-------------------GRLRDVVAQAG----AET 50
            |:...|.|  ...||.||.::|..||..                   |..||.:::..    :.|
Zfish     9 WLGDEAVR--PAALAALWALMALEGRCLRPASPTPGQRRARRRHTRPGTPRDDLSRLTVALLSRT 71

  Fly    51 GLLALSLCVNRSIHLLERLFWLAVVVSSVIAALVLSRLQLERYFSSPTVISVDRDYRGWNGSL-- 113
            .|..|....:.|..|..|.||:....:.:...|..|..:|..:.:.||...|..:   |...|
Zfish    72 RLHGLRHICSPSNSLSRRAFWMIAFCTCLGLLLSWSSNRLLHWLAFPTHTRVHTE---WAKELAF 133

  Fly   114 PAVTLCYYDHIDSF---KANEYIQEMWNVSIIDEDYFYFMDFLYAVVNATA-------------G 162
            |.||:|..:.:..:   |::.|....|            :..|.|  |.||             |
Zfish   134 PTVTICNNNPVRLYHLTKSDLYFAGHW------------LGLLLA--NRTARPLVLDLLQDDRRG 184

  Fly   163 NYAELAK---FAEDERFDQIDLYEMIQRVDRPFEQVISSF-----DAGFQVHVQRVMTERGACYA 219
            .:::|:.   |....||:...| |.:.|:....|.::.:.     ..|.. :...|.|..|.||.
Zfish   185 WFSKLSDFRLFLPPRRFEGTSL-EFMDRLGHQLEDMLLACKYRGEPCGAH-NFSTVFTRYGKCYM 247

  Fly   220 INSP------MSTVLSGQPVAYELMPQPLSCQYGKQQCYIRMDLYESTGVLDVHSPFEVSATEAN 278
            .|:.      .:|:..|.....|:|..            |:.|.|     |.|....|.:|.||.
Zfish   248 FNAAEEGKTLRTTMKGGTGNGLEIMLD------------IQQDEY-----LPVWGETEETAFEAG 295

  Fly   279 I-VALHKSDE----------ITASFKVLETVASKNLRQLSVAQRKCVFNNEETSNLKIYSKSLCL 332
            : |.:|...|          :...|:.......:.|..|.....:||....::...::||.|.|.
Zfish   296 VRVQIHSQAEPPFVHELGFGVAPGFQTFVATQEQRLTYLPPPWGECVSRALDSGLFQVYSVSACR 360

  Fly   333 ARCRAVMALEMCNCVPFFYPYVDGPSCNPAGFECLLDFKWP-IWALHI-----CKCPSTC----- 386
            ..|.....:|.|||...:.| .|.|.|.|..::   |...| :.||..     |.|.|.|
Zfish   361 IECETRYIVENCNCRMVYMP-GDSPYCTPEQYK---DCAEPALAALSAVEGTNCICRSPCNMTRY 421

  Fly   387 ------------TEIEYTMQTVKKSSWGVKNNEEVASSETATSSFRWDLIPPKVRMRRDVVYSFE 439
                        |...|..:...:|...:.:|  :...:....:..::.|..|      ..|...
Zfish   422 NKELSMVKIPSKTSARYLEKKFNRSEKYITDN--ILVLDVFFEALNYETIEQK------KAYEVA 478

  Fly   440 DLVVSFGGVLALFVGVSVMGLVEM---VHVLVNNLLLDV 475
            .|:...||.:.||:|.|::.|:|:   .:.:|...|||:
Zfish   479 GLLGDIGGQMGLFIGASILTLLELFDYAYEVVKERLLDL 517

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ppk3	NP_726336.1	ASC	59..464	CDD:279230	100/473 (21%)
asic2	XP_005164179.1	ASC	71..538	CDD:295594	107/495 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D303969at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.920