Protein Alignment ppk3 and Asic2

DIOPT Version :10

• Sequence 1: NP_726336.1
• Gene: ppk3 / 246504
• FlyBaseID: FBgn0050181
• Length: 535
• Species: Drosophila melanogaster
• Sequence 2: NP_037024.2
• Gene: Asic2 / 25364
• RGDID: 2017
• Length: 563
• Species: Rattus norvegicus
• Alignment Length: 542
• Identity: 120/542 - (22%)
• Similarity: 193/542 - (35%)
• Gaps: 125/542 - (23%)

  Fly    43 VAQAG----AETGLLAL-SLCVNRSI---HLLERLFWLAVVVSSVIAALVLSRLQLERYFSSPTV 99
            ||:.|    :.|.|..| .:|..|:.   ....|..|:....:|:...|..|..:|..:.|.|
  Rat    53 VARRGRPSLSRTKLHGLRHMCAGRTAAGGSFQRRALWVLAFCTSLGLLLSWSSNRLLYWLSFP-- 115

  Fly   100 ISVDRDYRGWNGSL--PAVTLCYYDHIDSFKANEYIQEMWNVSIIDEDYFYFMDFLYAVV-NATA 161
             |..|.:|.|:..|  ||||:|..:.:...:.::            .|.:|...:|..:: |.||
  Rat   116 -SHTRVHREWSRQLPFPAVTVCNNNPLRFPRLSK------------GDLYYAGHWLGLLLPNRTA 167

  Fly   162 GN-YAELAKFAEDER--FDQIDLYEMIQRVDRPFEQVISSF--DAGFQV---------------- 205
            .. .:||.:..|..|  |.::..:.:. ...|.||.:.::|  ..|.|:
  Rat   168 RPLVSELLRGDEPRRQWFRKLADFRLF-LPPRHFEGISAAFMDRLGHQLEDMLLSCKYRGELCGP 231

  Fly   206 -HVQRVMTERGACYAINSP------MSTVLSGQPVAYELMPQPLSCQYGKQQCYIRMDLYESTGV 263
             :...|.|:.|.||..||.      ::||..|.....|:|..            |:.|.|
  Rat   232 HNFSSVFTKYGKCYMFNSGEDGKPLLTTVKGGTGNGLEIMLD------------IQQDEY----- 279

  Fly   264 LDVHSPFEVSATEANI-VALHKSDE----------ITASFKVLETVASKNLRQLSVAQRKCVFNN 317
            |.:....|.:..||.: |.:|...|          :...|:.......:.|..|.....:|..:.
  Rat   280 LPIWGETEETTFEAGVKVQIHSQSEPPFIQELGFGVAPGFQTFVATQEQRLTYLPPPWGECRSSE 344

  Fly   318 EETSNLKIYSKSLCLARCRAVMALEMCNCVPFFYPYVDGPSCNPAGF-EC------LLDFKWPIW 375
            .......:||.:.|...|.....:|.|||.....| .|.|.|.|... ||      ||..|...:
  Rat   345 MGLDFFPVYSITACRIDCETRYIVENCNCRMVHMP-GDAPFCTPEQHKECAEPALGLLAEKDSNY 408

  Fly   376 ALHICKCPSTCTEIEYTMQTVK-KSSWGVK------NNEEVASSETAT------SSFRWDLIPPK 427
            .|  |:.|...|.....:..|| .|....|      |..|...||...      .:..::.|..|
  Rat   409 CL--CRTPCNLTRYNKELSMVKIPSKTSAKYLEKKFNKSEKYISENILVLDIFFEALNYETIEQK 471

  Fly   428 VRMRRDVVYSFEDLVVSFGGVLALFVGVSVMGLVEM---VHVLVNNLLLDVFTLLRLMLGRLRRC 489
                  ..|....|:...||.:.||:|.|::.::|:   ::.|:...|||       :||:....
  Rat   472 ------KAYEVAALLGDIGGQMGLFIGASLLTILELFDYIYELIKEKLLD-------LLGKEEEE 523

  Fly   490 WRRDDHMREAN---HHHHANAH 508
            ...|::|...:   :|....:|
  Rat   524 GSHDENMSTCDTMPNHSETISH 545

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ppk3	NP_726336.1	ASC	59..464	CDD:459966	103/472 (22%)
Asic2	NP_037024.2	ENaC	64..557	CDD:273304	117/531 (22%)