Protein Alignment ppk3 and Scnn1a

DIOPT Version :10

• Sequence 1: NP_726336.1
• Gene: ppk3 / 246504
• FlyBaseID: FBgn0050181
• Length: 535
• Species: Drosophila melanogaster
• Sequence 2: NP_113736.1
• Gene: Scnn1a / 25122
• RGDID: 3639
• Length: 699
• Species: Rattus norvegicus
• Alignment Length: 581
• Identity: 114/581 - (19%)
• Similarity: 187/581 - (32%)
• Gaps: 196/581 - (33%)

  Fly    58 CVNRSIHLLERL-----------FWLAVVVSSVIAALVLSRLQLERYFSSPTVISVDRDYRGWNG 111
            |.|.:||...||           ||..:.:.:.........|..|.|.|.|..::::     .|.
  Rat    89 CNNTTIHGAIRLVCSKHNRMKTAFWAVLWLCTFGMMYWQFALLFEEYLSYPVSLNIN-----LNS 148

  Fly   112 S---LPAVTLCYYDHIDSFKANEYIQEMWNVSIIDEDYFYFM-------------------DFL- 153
            .   .||||:|   .::.::..|..:|:..:..|.|...:.:                   |.|
  Rat   149 DKLVFPAVTVC---TLNPYRYTEIKEELEELDRITEQTLFDLYKYNSSYTRQAGARRRSSRDLLG 210

  Fly   154 ---------------YAVVNATAGNYAELAKFAEDERFD-QIDLYEMIQRVDRPFEQVISS-FDA 201
                           |:...|.:|:.:......:.:|.| :|......|.....|.|..|| .||
  Rat   211 AFPHPLQRLRTPPPPYSGRTARSGSSSVRDNNPQVDRKDWKIGFQLCNQNKSDCFYQTYSSGVDA 275

  Fly   202 ---GFQVHVQRVMTERGACYAINSPMSTVLSGQPVA-----------------YELMPQPLSCQY 246
               .::.|...:::..       |..|..|..:.:.                 |.....|:   |
  Rat   276 VREWYRFHYINILSRL-------SDTSPALEEEALGNFIFTCRFNQAPCNQANYSKFHHPM---Y 330

  Fly   247 GKQQCYIRMDLYEST-------GVLDVHS-----------PFEVSATEANIVALHKSDEITASFK 293
            |  .||...|...|.       ||.:..|           |...:.|.|.:: :|..||     .
  Rat   331 G--NCYTFNDKNNSNLWMSSMPGVNNGLSLTLRTEQNDFIPLLSTVTGARVM-VHGQDE-----P 387

  Fly   294 VLETVASKNLR---QLSVAQRK------------CVFNNEE--TSNL--KIYSKSLCLARCRAVM 339
            ........|||   :.|::.||            |..|..:  ..||  ..|::.:|:..|....
  Rat   388 AFMDDGGFNLRPGVETSISMRKEALDSLGGNYGDCTENGSDVPVKNLYPSKYTQQVCIHSCFQEN 452

  Fly   340 ALEMCNCVPFFYPYVDGPSCNPAGFECLLDF-KWPIWALHIC-----------------KCPSTC 386
            .::.|.|...|||       .|.|.| ..|: |...|.  .|                 ||...|
  Rat   453 MIKKCGCAYIFYP-------KPKGVE-FCDYRKQSSWG--YCYYKLQGAFSLDSLGCFSKCRKPC 507

  Fly   387 TEIEYTMQ-------TVKKSSW-----GVKNNEEVASSETATS---------SFRWDLIPPKVRM 430
            :.|.|.:.       :||...|     .::||..:.:.....:         :::.:...|.|.|
  Rat   508 SVINYKLSAGYSRWPSVKSQDWIFEMLSLQNNYTINNKRNGVAKLNIFFKELNYKTNSESPSVTM 572

  Fly   431 RRDVVYSFEDLVVSFGGVLALFVGVSVMGLVEMVHVLVNNLLLDVFTLLRLMLGRLR-RCW 490
                    ..|:.:.|...:|:.|.||:.:|||..::.:.|::.:..|||    |.| |.|
  Rat   573 --------VSLLSNLGSQWSLWFGSSVLSVVEMAELIFDLLVITLLMLLR----RFRSRYW 621

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ppk3	NP_726336.1	ASC	59..464	CDD:459966	104/551 (19%)
Scnn1a	NP_113736.1	ENaC	80..677	CDD:273304	114/581 (20%)