DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ppk3 and Scnn1a

DIOPT Version :9

Sequence 1:	NP_726336.1	Gene:	ppk3 / 246504	FlyBaseID:	FBgn0050181	Length:	535	Species:	Drosophila melanogaster
Sequence 2:	NP_113736.1	Gene:	Scnn1a / 25122	RGDID:	3639	Length:	699	Species:	Rattus norvegicus

Alignment Length:	581	Identity:	114/581 - (19%)
Similarity:	187/581 - (32%)	Gaps:	196/581 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    58 CVNRSIHLLERL-----------FWLAVVVSSVIAALVLSRLQLERYFSSPTVISVDRDYRGWNG 111
            |.|.:||...||           ||..:.:.:.........|..|.|.|.|..::::     .|.
  Rat    89 CNNTTIHGAIRLVCSKHNRMKTAFWAVLWLCTFGMMYWQFALLFEEYLSYPVSLNIN-----LNS 148

  Fly   112 S---LPAVTLCYYDHIDSFKANEYIQEMWNVSIIDEDYFYFM-------------------DFL- 153
            .   .||||:|   .::.::..|..:|:..:..|.|...:.:                   |.|
  Rat   149 DKLVFPAVTVC---TLNPYRYTEIKEELEELDRITEQTLFDLYKYNSSYTRQAGARRRSSRDLLG 210

  Fly   154 ---------------YAVVNATAGNYAELAKFAEDERFD-QIDLYEMIQRVDRPFEQVISS-FDA 201
                           |:...|.:|:.:......:.:|.| :|......|.....|.|..|| .||
  Rat   211 AFPHPLQRLRTPPPPYSGRTARSGSSSVRDNNPQVDRKDWKIGFQLCNQNKSDCFYQTYSSGVDA 275

  Fly   202 ---GFQVHVQRVMTERGACYAINSPMSTVLSGQPVA-----------------YELMPQPLSCQY 246
               .::.|...:::..       |..|..|..:.:.                 |.....|:   |
  Rat   276 VREWYRFHYINILSRL-------SDTSPALEEEALGNFIFTCRFNQAPCNQANYSKFHHPM---Y 330

  Fly   247 GKQQCYIRMDLYEST-------GVLDVHS-----------PFEVSATEANIVALHKSDEITASFK 293
            |  .||...|...|.       ||.:..|           |...:.|.|.:: :|..||     .
  Rat   331 G--NCYTFNDKNNSNLWMSSMPGVNNGLSLTLRTEQNDFIPLLSTVTGARVM-VHGQDE-----P 387

  Fly   294 VLETVASKNLR---QLSVAQRK------------CVFNNEE--TSNL--KIYSKSLCLARCRAVM 339
            ........|||   :.|::.||            |..|..:  ..||  ..|::.:|:..|....
  Rat   388 AFMDDGGFNLRPGVETSISMRKEALDSLGGNYGDCTENGSDVPVKNLYPSKYTQQVCIHSCFQEN 452

  Fly   340 ALEMCNCVPFFYPYVDGPSCNPAGFECLLDF-KWPIWALHIC-----------------KCPSTC 386
            .::.|.|...|||       .|.|.| ..|: |...|.  .|                 ||...|
  Rat   453 MIKKCGCAYIFYP-------KPKGVE-FCDYRKQSSWG--YCYYKLQGAFSLDSLGCFSKCRKPC 507

  Fly   387 TEIEYTMQ-------TVKKSSW-----GVKNNEEVASSETATS---------SFRWDLIPPKVRM 430
            :.|.|.:.       :||...|     .::||..:.:.....:         :::.:...|.|.|
  Rat   508 SVINYKLSAGYSRWPSVKSQDWIFEMLSLQNNYTINNKRNGVAKLNIFFKELNYKTNSESPSVTM 572

  Fly   431 RRDVVYSFEDLVVSFGGVLALFVGVSVMGLVEMVHVLVNNLLLDVFTLLRLMLGRLR-RCW 490
                    ..|:.:.|...:|:.|.||:.:|||..::.:.|::.:..|||    |.| |.|
  Rat   573 --------VSLLSNLGSQWSLWFGSSVLSVVEMAELIFDLLVITLLMLLR----RFRSRYW 621

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ppk3	NP_726336.1	ASC	59..464	CDD:279230	104/551 (19%)
Scnn1a	NP_113736.1	ENaC	80..677	CDD:273304	114/581 (20%)
Scnn1a	NP_113736.1	deg-1	88..600	CDD:273309	106/554 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4294
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D303969at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820