DRSC/TRiP Functional Genomics Resources

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Protein Alignment ppk3 and Scnn1g

DIOPT Version :10

Sequence 1:NP_726336.1 Gene:ppk3 / 246504 FlyBaseID:FBgn0050181 Length:535 Species:Drosophila melanogaster
Sequence 2:NP_058742.2 Gene:Scnn1g / 24768 RGDID:3641 Length:650 Species:Rattus norvegicus


Alignment Length:637 Identity:123/637 - (19%)
Similarity:225/637 - (35%) Gaps:238/637 - (37%)


- Green bases have known domain annotations that are detailed below.


  Fly    10 IRGAAARILRGLLALLWLIL----AGCGRLF---GRLRDVVAQAGAETGLLALSLCVNRSIHLLE 67
            :||..|..::.|:.  |..:    .||.|:.   ||||                           
  Rat    17 VRGPQAPTIKDLMH--WYCMNTNTHGCRRIVVSRGRLR--------------------------- 52

  Fly    68 RLFWLAVVVSSVIAALVLSRLQLERYFSSPTV-ISVDRDYRGWNGSLPAVTLCYYDHIDSFKANE 131
            ||.|:|..:::|  ||::.:..| ..||..|| :|:...::..:  .||||:|   :|:.:|.:.
  Rat    53 RLLWIAFTLTAV--ALIIWQCAL-LVFSFYTVSVSIKVHFQKLD--FPAVTIC---NINPYKYSA 109

  Fly   132 YIQEMWNVSIIDEDYFYFMDFLYAVVNA----TAGNYAE--------------LAKFAEDERFDQ 178
             :.::  ::.:|.:....:..||.|..:    .||:...              |..|.|:|:...
  Rat   110 -VSDL--LTDLDSETKQALLSLYGVKESRKRREAGSMPSTLEGTPPRFFKLIPLLVFNENEKGKA 171

  Fly   179 IDLY---------EMIQRVDR--------------------------PFEQVISSFDAGFQVHVQ 208
            .|.:         ::|.:...                          .|...|::....:::|..
  Rat   172 RDFFTGRKRKISGKIIHKASNVMHVHESKKLVGFQLCSNDTSDCATYTFSSGINAIQEWYKLHYM 236

  Fly   209 RVMTE---------------------------------------RGACYAINSP-----MSTVLS 229
            .:|.:                                       .|.||..|:.     :||.:.
  Rat   237 NIMAQVPLEKKINMSYSAKELLVTCFFDGMSCDARNFTLFHHPMYGNCYTFNNKENATILSTSMG 301

  Fly   230 GQPVAYELMPQPLSCQYGKQQ-CYIRMDLYESTGVLDVHSPFEVSATEANIVALHKSDEITASFK 293
            |.             :||.|. .||..|.|         :||.||:|.|.:: :|:.:|......
  Rat   302 GS-------------EYGLQVILYINEDEY---------NPFLVSSTGAKVL-IHQQNEYPFIED 343

  Fly   294 V---LETVASKNLR-------QLSVAQRKCVFNNEETSNLKI-------YSKSLCLARCRAVMAL 341
            |   :||..|.::.       :||....:|   .|:.|::.:       ||..:||..|.....:
  Rat   344 VGMEIETAMSTSIGMHLTESFKLSEPYSQC---TEDGSDVPVTNIYNAAYSLQICLYSCFQTKMV 405

  Fly   342 EMCNCVPFFYPYVDGPSCNPAGFECLLDFKWPIWALHI--------CK--CPSTCTEIEYTMQTV 396
            |.|.|..:..|.  .|:.|...::...::.:..:.|:.        |:  |..:|:..|:|: |.
  Rat   406 EKCGCAQYSQPL--PPAANYCNYQQHPNWMYCYYQLYQAFVREELGCQSVCKQSCSFKEWTL-TT 467

  Fly   397 KKSSWGVKNNEEVASSETATSSFRWD-----------------LIPPKVRMRRDVV----YSFED 440
            ..:.|     ...||.:...:...||                 ||..|...:|.::    .|.|.
  Rat   468 SLAQW-----PSEASEKWLLNVLTWDQSQQINKKLNKTDLAKLLIFYKDLNQRSIMESPANSIEM 527

  Fly   441 LVVSFGGVLALFVGVSVMGLVEMVHVLVNNLLLDVFTLLRLMLGRLRRCWRR 492
            |:.:|||.|.|::..||:.::|::.|    ..:|.|:::      .||.|.:
  Rat   528 LLSNFGGQLGLWMSCSVVCVIEIIEV----FFIDFFSII------ARRQWHK 569

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ppk3NP_726336.1 ASC 59..464 CDD:459966 105/551 (19%)
Scnn1gNP_058742.2 ENaC 24..631 CDD:273304 120/630 (19%)
Gating release of inhibition by proteolysis (GRIP), protease-sensitive region that is responsible for the proteolytic activation of the channel. /evidence=ECO:0000250|UniProtKB:P51170 135..222 9/86 (10%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 577..628
PY motif, mediates interaction, ubiquitination and inhibition by NEDD4 and NEDD4L. /evidence=ECO:0000269|PubMed:12654927 624..628
PY motif, recruits WW domain-containing proteins and is thereby required for ubiquitination and inhibition of the channel by NEDD4 and NEDD4L. /evidence=ECO:0000250|UniProtKB:P51170 624..628
Blue background indicates that the domain is not in the aligned region.

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