DRSC/TRiP Functional Genomics Resources

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Protein Alignment ppk3 and Scnn1b

DIOPT Version :10

Sequence 1:NP_726336.1 Gene:ppk3 / 246504 FlyBaseID:FBgn0050181 Length:535 Species:Drosophila melanogaster
Sequence 2:NP_036780.1 Gene:Scnn1b / 24767 RGDID:3640 Length:638 Species:Rattus norvegicus


Alignment Length:563 Identity:104/563 - (18%)
Similarity:191/563 - (33%) Gaps:161/563 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly    58 CVNRSIHLLERL---------FWLAVVVSSVIAALVLSR--LQLERYFSSPTVISVDRDYRGWNG 111
            |.|.:.|..:|:         .|.  :::.:.|.||..:  :.::.|.|....:|:...::..| 
  Rat    30 CNNTNTHGPKRIICEGPKKKAMWF--LLTLLFACLVCWQWGVFIQTYLSWEVSVSLSMGFKTMN- 91

  Fly   112 SLPAVTLCYYDHIDSFKANEYIQEMWNV--SIIDEDYFYFMDFLYA----------VVNATAGNY 164
             .||||:|........|....:::::.:  :::|:        :.|          .:|.|..|:
  Rat    92 -FPAVTVCNSSPFQYSKVKHLLKDLYKLMEAVLDK--------ILAPKSSHTNTTSTLNFTIWNH 147

  Fly   165 AELAKFAEDERFDQIDLYEMIQRVDRPFEQVISSFD----------------AGFQVHVQRVMTE 213
            ..|...  |||           ..|.|.  |::.|.                .|.:|.::.....
  Rat   148 TPLVLI--DER-----------NPDHPV--VLNLFGDSHNSSNPAPGSTCNAQGCKVAMRLCSAN 197

  Fly   214 RGACYAINSPMST-------VLSGQPVAYELMPQP------------LSCQYGKQQCYIR---MD 256
            ...|...|...:|       :|....:..:::||.            |:|.:|.:.|..|   ..
  Rat   198 GTVCTFRNFTSATQAVTEWYILQATNIFSQVLPQDLVGMGYAPDRIILACLFGTEPCSHRNFTPI 262

  Fly   257 LYESTG---------------------------VLDV----HSPFEVSATEANIVALHKS----- 285
            .|...|                           :||:    :.||..|...|.:: ||:.     
  Rat   263 FYPDYGNCYIFNWGMTEKALPSANPGTEFGLKLILDIGQEDYVPFLASTAGARLM-LHEQRTYPF 326

  Fly   286 --DEITASFKVLET---VASKNLRQLSVAQRKCVFNNEETSNLKIYSK-------SLCLARCRAV 338
              :|...:....||   |....|:........|..|..:.:...:||.       ..||..|...
  Rat   327 IREEGIYAMAGTETSIGVLLDKLQGKGEPYSPCTMNGSDVAIQNLYSDYNTTYSIQACLHSCFQD 391

  Fly   339 MALEMCNCVPFFYPYVDGPS-CNPAGFE----CLLDFKWPIWALHIC--KCPSTCTEIEYTMQTV 396
            ..:..|:|..:.||...|.. ||...|.    |.|..:..:.....|  .|..:|.:.:|.| |:
  Rat   392 HMIHNCSCGHYLYPLPAGEKYCNNRDFPDWAYCYLSLQMSVVQRETCLSMCKESCNDTQYKM-TI 455

  Fly   397 KKSSWGVKNNEE----VASSETATSS----FRWDLIPPKVRMRRDVVYSFED--------LVVSF 445
            ..:.|..:.:|:    |.|.|...||    .|..::...:..:.....:.|:        |:.:.
  Rat   456 SMADWPSEASEDWILHVLSQERDQSSNITLSRKGIVKLNIYFQEFNYRTIEESPANNIVWLLSNL 520

  Fly   446 GGVLALFVGVSVMGLVEMVHVLVNNLLLDVFTLLRLMLGRLRR 488
            ||....::|.||:.|:|...::::.:.:.|..|:....|..||
  Rat   521 GGQFGFWMGGSVLCLIEFGEIIIDFIWITVIKLVASCKGLRRR 563

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ppk3NP_726336.1 ASC 59..464 CDD:459966 98/536 (18%)
Scnn1bNP_036780.1 ENaC 21..621 CDD:273304 104/563 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 598..620
PY motif, recruits WW domain-containing proteins and is thereby required for ubiquitination and inhibition of the channel by NEDD4 and NEDD4L. /evidence=ECO:0000269|PubMed:12654927, ECO:0000269|PubMed:8665844 614..618
Blue background indicates that the domain is not in the aligned region.

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