DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ppk3 and del-4

DIOPT Version :9

Sequence 1:	NP_726336.1	Gene:	ppk3 / 246504	FlyBaseID:	FBgn0050181	Length:	535	Species:	Drosophila melanogaster
Sequence 2:	NP_492230.2	Gene:	del-4 / 189033	WormBaseID:	WBGene00012116	Length:	527	Species:	Caenorhabditis elegans

Alignment Length:	509	Identity:	105/509 - (20%)
Similarity:	166/509 - (32%)	Gaps:	191/509 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly    68 RLFWLAVVVSSVIAALVLSRLQLERYFS-----SPTVISVDRDYRGWNGSLPAVTLCYYDHIDSF 127
            |.||:.|||.|:...:......|..|.|     ..|:...:|.:       |.||:|   |::.:
Worm    36 RAFWILVVVVSIALFIWQFITLLTNYLSFSVNTETTLQFAERTF-------PTVTIC---HLNPW 90

  Fly   128 KANEYIQEMWNVSIIDEDYFYFMDFLYAVVNATAGNYAELAKFAEDERFDQIDLYEMIQRVDRPF 192
            |.:|       ...:|.|       :.|:::|          :..|....|..|...: ..||
Worm    91 KLSE-------TKSVDPD-------MSALIDA----------YNSDSSSAQFGLPASL-TADR-- 128

  Fly   193 EQVISSFDAGFQVHVQRVMTERGACYAINSPMSTVLSGQPVAYELMPQPLSCQYGKQQCYIR--M 255
            :|..|.:...:...:........|               .:||......:||.|..:.|.|.  .
Worm   129 QQQASKWTLMYSERLNEKQYNDAA---------------DIAYSYDDMVVSCTYNAKTCNITDFN 178

  Fly   256 DLYEST------------------GVL-----------DVHSPFEVSATEAN--IVALHKSDEI- 288
            |.|..:                  |.|           |.:.|:    |||:  |:.:|..|||
Worm   179 DFYNPSYGNCLQFNTDGMYSSSRAGPLYGLRMVMRTDQDTYLPW----TEASGVIIDIHMQDEIP 239

  Fly   289 ------------TASFKVLETVASKNLRQLSVAQRKCVFNNEETSNLKI--------YSKSLCLA 333
                        |||...:..|.:   .:||.....|      |:..|:        |:...|..
Worm   240 YPDVFGYFAPPGTASSLGVSYVQT---TRLSKPYGSC------TTKTKLKTTHYTGTYTVEACFR 295

  Fly   334 RCRAVMALEMCNCVPFFYP----------YVDGPSC----------------NPAG---FECLLD 369
            .|.....:..|.|   :||          ||   ||                |.|.   |:.|.|
Worm   296 SCMQEKIIASCGC---YYPAYSHASNTTQYV---SCDNGVQTLSNLNCVDLINSADSTEFDVLTD 354

  Fly   370 FKWPIWALHICKCPSTCTEIEYTMQTVKKSSW------------GVKNNEEVASSETATSSFRWD 422
                      |.||..| ||:....||..:.|            |..:....||.|:....::.:
Worm   355 ----------CDCPQPC-EIDSYGVTVSTAQWPSDSYVPTECNPGGPSGPWDASGESCLDWYKAN 408

  Fly   423 LIPPKV---RMRRDVV-----YSFEDLVVSFGGVLALFVGVSVMGLVEMVHVLV 468
            .|..::   ||...|:     |:|.:.:...||.:.||:|:|::..:|.: ||:
Worm   409 TILIEIYYERMNFQVLTESPAYTFVNFISDVGGQVGLFLGMSIISAIEYL-VLI 461

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ppk3	NP_726336.1	ASC	59..464	CDD:279230	103/503 (20%)
del-4	NP_492230.2	ASC	8..466	CDD:295594	105/509 (21%)
del-4	NP_492230.2	deg-1	14..460	CDD:273309	103/506 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4294
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D303969at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11690
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.920