Protein Alignment ppk3 and Asic3

DIOPT Version :10

• Sequence 1: NP_726336.1
• Gene: ppk3 / 246504
• FlyBaseID: FBgn0050181
• Length: 535
• Species: Drosophila melanogaster
• Sequence 2: XP_006535700.1
• Gene: Asic3 / 171209
• MGIID: 2159339
• Length: 563
• Species: Mus musculus
• Alignment Length: 576
• Identity: 114/576 - (19%)
• Similarity: 184/576 - (31%)
• Gaps: 167/576 - (28%)

  Fly    31 GCGRLFGRLRDVVAQAGAETGLLALSLCVNRSIHLLERLFWLAVVVSSVIAAL--VLSRLQLERY 93
            |.|.:||        .|..|               |.|..|...|:.|:.|.|  |..|::....
Mouse    29 GLGHIFG--------PGGLT---------------LRRGLWATAVLLSLAAFLYQVAERVRYYGE 70

  Fly    94 FSSPTVISVDRDYRGWNGSLPAVTLCYYDHIDSFKANEYIQEMWNVSIIDEDYFYFMDFLYAVVN 158
            |...|.:.....::   .:.||||||..:.:...:...........:::..|......:|.|:
Mouse    71 FHHKTTLDERESHQ---LTFPAVTLCNINPLRRSRLTPNDLHWAGTALLGLDPAEHAAYLRAL-- 130

  Fly   159 ATAGNYAELAKFAEDERFDQIDLYEMIQRVDRPFEQVISSFDAGFQ------VHVQRVMTERGAC 217
               |.......|.....||...||   .|.....|.::  .|..::      .:...:.|..|.|
Mouse   131 ---GQPPAPPGFMPSPTFDMAQLY---ARAGHSLEDML--LDCRYRGQPCGPENFTVIFTRMGQC 187

  Fly   218 YAINSP------MSTVLSGQPVAYELMPQPLSCQYGKQQCYIRM--DLYESTGVLDVHSPFEVSA 274
            |..||.      ::|...|.....|:|   |..|   |:.|:.:  |:.|        :||||..
Mouse   188 YTFNSGAQGAELLTTPKGGAGNGLEIM---LDVQ---QEEYLPIWKDMEE--------TPFEVGI 238

  Fly   275 TEANIVALHKSDEITASFKV-------LETVASKNLRQLS----------VAQRKCVFNNEET-- 320
            .    |.:|..:|..|..::       .:|..|...:|||          .|.....|:.|.:
Mouse   239 R----VQIHGQEEPPAIDQLGFGAAPGHQTFVSCQQQQLSFLPPPWGDCNTASVDPDFDPEPSDP 299

  Fly   321 ----SNLKIYSKSLCLARCRAVMALEMCNCVPFFYPYVDGPSCNPAGF-ECLLD-------FKWP 373
                |:...||...|...|.:......|.|.....| .:.|.|:|..: :|...       |..|
Mouse   300 LGSPSSSPPYSLIGCRLACESRYVARKCGCRMMHMP-GNSPVCSPQQYKDCASPALGKAHLFSLP 363

  Fly   374 IWALH---------------------------ICKCPSTCTEIEYT--MQTVKKSSWGVK----- 404
            : .:|                           .|.||:.|....|.  :..|:..|....
Mouse   364 V-PIHSDIDHNPLGQVLLFLALRPADAMLRKDTCVCPNPCATTRYAKELSMVRIPSRASARYLAR 427

  Fly   405 --NNEEVASSETAT------SSFRWDLIPPKVRMRRDVVYSFEDLVVSFGGVLALFVGVSVMGLV 461
              |..|...:|...      .:..::.:..|      ..|...:|:...||.:.||:|.|::.::
Mouse   428 KYNRSETYITENVLVLDIFFEALNYEAVEQK------AAYEVSELLGDIGGQMGLFIGASLLTIL 486

  Fly   462 EMVHVLVNNLLLDVFTLLRLMLGRLRRCWRRDDHMREANH---HHHANAHAHARLH 514
            |::     :.|.:||.  ..:||..   |.|....|.:.:   ....|.|   |.|
Mouse   487 EIL-----DYLCEVFQ--DRVLGYF---WNRRSSQRRSGNTLLQEELNGH---RTH 529

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ppk3	NP_726336.1	ASC	59..464	CDD:459966	96/493 (19%)
Asic3	XP_006535700.1	ENaC	21..546	CDD:273304	114/576 (20%)