Protein Alignment ppk3 and Asic2

DIOPT Version :10

• Sequence 1: NP_726336.1
• Gene: ppk3 / 246504
• FlyBaseID: FBgn0050181
• Length: 535
• Species: Drosophila melanogaster
• Sequence 2: XP_006532059.1
• Gene: Asic2 / 11418
• MGIID: 1100867
• Length: 596
• Species: Mus musculus
• Alignment Length: 582
• Identity: 120/582 - (20%)
• Similarity: 193/582 - (33%)
• Gaps: 162/582 - (27%)

  Fly    40 RDVVAQAGAETGLLALS---------LCVNRSI---HLLERLFWLAVVVSSVIAALVLSRLQLER 92
            |::.....|..|..:||         :|..|:.   ....|..|:....:|:...|..|..:|..
Mouse    46 RELQGPGVARRGRPSLSRTKLHGLRHMCAGRTAAGGSFQRRALWVLAFCTSLGLLLSWSSNRLLY 110

  Fly    93 YFSSPTVISVDRDYRGWNGSL--PAVTLCYYDHIDSFKANEYIQEMWNVSIIDEDYFYFMDFLYA 155
            :.|.|   |..|.:|.|:..|  ||||:|..:.:...:.::            .|.:|...:|..
Mouse   111 WLSFP---SHTRVHREWSRQLPFPAVTVCNNNPLRFPRLSK------------GDLYYAGHWLGL 160

  Fly   156 VV-NATAGN-YAELAKFAEDER--FDQIDLYEMIQRVDRPFEQVISSF--DAGFQV--------- 205
            :: |.||.. .:||.:..|..|  |.::..:.:. ...|.||.:.::|  ..|.|:
Mouse   161 LLPNRTARPLVSELLRGDEPRRQWFRKLADFRLF-LPPRHFEGISAAFMDRLGHQLEDMLLSCKY 224

  Fly   206 -----------------------------------------HVQRVMTERGACYAINSP------ 223
                                                     |...|.|:.|.||..||.
Mouse   225 RGELCGPHNFSSVSCPPREPALSDPALPRSPEALRWAPGTGHQAPVFTKYGKCYMFNSGEDGKPL 289

  Fly   224 MSTVLSGQPVAYELMPQPLSCQYGKQQCYIRMDLYESTGVLDVHSPFEVSATEANI-VALHKSDE 287
            ::||..|.....|:|..            |:.|.|     |.:....|.:..||.: |.:|...|
Mouse   290 LTTVKGGTGNGLEIMLD------------IQQDEY-----LPIWGETEETTFEAGVKVQIHSQSE 337

  Fly   288 ----------ITASFKVLETVASKNLRQLSVAQRKCVFNNEETSNLKIYSKSLCLARCRAVMALE 342
                      :...|:.......:.|..|.....:|..:........:||.:.|...|.....:|
Mouse   338 PPFIQELGFGVAPGFQTFVATQEQRLTYLPPPWGECRSSEMGLDFFPVYSITACRIDCETRYIVE 402

  Fly   343 MCNCVPFFYPYVDGPSCNPAGF-EC------LLDFKWPIWALHICKCPSTCTEIEYTMQTVK-KS 399
            .|||.....| .|.|.|.|... ||      ||..|...:.|  |:.|...|.....:..|| .|
Mouse   403 NCNCRMVHMP-GDAPFCTPEQHKECAEPALGLLAEKDSNYCL--CRTPCNLTRYNKELSMVKIPS 464

  Fly   400 SWGVK------NNEEVASSETAT------SSFRWDLIPPKVRMRRDVVYSFEDLVVSFGGVLALF 452
            ....|      |..|...||...      .:..::.|..|      ..|....|:...||.:.||
Mouse   465 KTSAKYLEKKFNKSEKYISENILVLDIFFEALNYETIEQK------KAYEVAALLGDIGGQMGLF 523

  Fly   453 VGVSVMGLVEM---VHVLVNNLLLDVFTLLRLMLGRLRRCWRRDDHMREAN---HHHHANAH 508
            :|.|::.::|:   ::.|:...|||       :||:.......|::|...:   :|....:|
Mouse   524 IGASILTILELFDYIYELIKEKLLD-------LLGKEEEEGSHDENMSTCDTMPNHSETISH 578

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ppk3	NP_726336.1	ASC	59..464	CDD:459966	104/505 (21%)
Asic2	XP_006532059.1	ENaC	64..590	CDD:273304	115/564 (20%)