DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG30178 and LPXN

DIOPT Version :9

Sequence 1:	NP_726395.1	Gene:	CG30178 / 246501	FlyBaseID:	FBgn0050178	Length:	187	Species:	Drosophila melanogaster
Sequence 2:	NP_001137467.1	Gene:	LPXN / 9404	HGNCID:	14061	Length:	391	Species:	Homo sapiens

Alignment Length:	169	Identity:	54/169 - (31%)
Similarity:	85/169 - (50%)	Gaps:	0/169 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 CCRCNEKIWPRAVCSLGKTYHPHHFTCKECGLVVDPKLFFAVDDDVVCSECYLDKHAARCSACRT 70
            |..|...|..:.:.::.:|:||.||.|..||.|...:.|...|....|.:.:|...:.:|..|..
Human   216 CAYCAAPILDKVLTAMNQTWHPEHFFCSHCGEVFGAEGFHEKDKKPYCRKDFLAMFSPKCGGCNR 280

  Fly    71 PILERGVAAAERKWHEKCFRCVSCSKSLVSASFFEVNGYLFCKAHFRELFSSRCAGCEKPIDRRA 135
            |:||..::|.:..||.:||.|..|..|..:.||||::|..||:.|:.....:.|.||.:||..|.
Human   281 PVLENYLSAMDTVWHPECFVCGDCFTSFSTGSFFELDGRPFCELHYHHRRGTLCHGCGQPITGRC 345

  Fly   136 VVALSTKWHAKCFKCHHCRKRISAREFWIENGQPICAAC 174
            :.|:..|:|.:.|.|..|..::|...|..:|.:..|..|
Human   346 ISAMGYKFHPEHFVCAFCLTQLSKGIFREQNDKTYCQPC 384

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG30178	NP_726395.1	LIM	6..61	CDD:295319	16/54 (30%)
		LIM	65..116	CDD:259829	20/50 (40%)
		LIM	124..171	CDD:295319	15/46 (33%)
LPXN	NP_001137467.1	LIM1_Leupaxin	155..209	CDD:188790
		LIM2_Leupaxin	216..267	CDD:188792	15/50 (30%)
		LIM3_Leupaxin	275..327	CDD:188794	21/51 (41%)
		LIM4_Paxillin_like	334..385	CDD:188725	17/51 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165149730
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1703
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1593918at2759
OrthoFinder	1	1.000	-	-		FOG0000055
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X39
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.750