DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG30178 and TGFB1I1

DIOPT Version :9

Sequence 1:	NP_726395.1	Gene:	CG30178 / 246501	FlyBaseID:	FBgn0050178	Length:	187	Species:	Drosophila melanogaster
Sequence 2:	NP_001035919.1	Gene:	TGFB1I1 / 7041	HGNCID:	11767	Length:	461	Species:	Homo sapiens

Alignment Length:	167	Identity:	61/167 - (36%)
Similarity:	83/167 - (49%)	Gaps:	0/167 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 ICCRCNEKIWPRAVCSLGKTYHPHHFTCKECGLVVDPKLFFAVDDDVVCSECYLDKHAARCSACR 69
            :|..||:.|..:.|.:||:.:||.||.|..|...:....||..|....|.|||.::.:.||..|.
Human   227 LCGSCNKPIAGQVVTALGRAWHPEHFVCGGCSTALGGSSFFEKDGAPFCPECYFERFSPRCGFCN 291

  Fly    70 TPILERGVAAAERKWHEKCFRCVSCSKSLVSASFFEVNGYLFCKAHFRELFSSRCAGCEKPIDRR 134
            .||..:.|.|....||.:.|.||||.:......|.|..|..:|:..|.:||:.||.||:.||...
Human   292 QPIRHKMVTALGTHWHPEHFCCVSCGEPFGDEGFHEREGRPYCRRDFLQLFAPRCQGCQGPILDN 356

  Fly   135 AVVALSTKWHAKCFKCHHCRKRISAREFWIENGQPIC 171
            .:.|||..||..||.|..|....|...|:...|:|:|
Human   357 YISALSALWHPDCFVCRECFAPFSGGSFFEHEGRPLC 393

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG30178	NP_726395.1	LIM	6..61	CDD:295319	20/54 (37%)
		LIM	65..116	CDD:259829	17/50 (34%)
		LIM	124..171	CDD:295319	18/46 (39%)
TGFB1I1	NP_001035919.1	Interaction with PTK2B/PYK2	1..240		4/12 (33%)
		Transcription activation. /evidence=ECO:0000250	1..200
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..87
		LD motif 1	3..15
		Interaction with PTK2/FAK1. /evidence=ECO:0000250	83..136
		Paxillin	<86..>106	CDD:308898
		LD motif 2	92..104
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	116..152
		LD motif 3	157..168
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	172..205
		LD motif 4	203..215
		LIM1_Paxillin_like	228..280	CDD:259830	19/51 (37%)
		LIM2_Paxillin_like	287..338	CDD:188723	17/50 (34%)
		LIM3_Paxillin	346..398	CDD:188793	19/48 (40%)
		LIM4_Leupaxin	405..456	CDD:188796
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165149725
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1703
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1593918at2759
OrthoFinder	1	1.000	-	-		FOG0000055
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1093
SonicParanoid	1	1.000	-	-		X39
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	7	6.780