DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG30178 and LIMS2

DIOPT Version :9

Sequence 1:	NP_726395.1	Gene:	CG30178 / 246501	FlyBaseID:	FBgn0050178	Length:	187	Species:	Drosophila melanogaster
Sequence 2:	NP_060450.2	Gene:	LIMS2 / 55679	HGNCID:	16084	Length:	365	Species:	Homo sapiens

Alignment Length:	178	Identity:	53/178 - (29%)
Similarity:	82/178 - (46%)	Gaps:	6/178 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 ICCRCNEKIWPRAVCSLGKTYHPHHFTCKECG--LVVDPKLFFAVDDDVVCSECYLDKHAARCSA 67
            ||.||:..|..:.:......|||.||.|..||  |..:.:   .:..::.|..|:.......|.|
Human   163 ICQRCHLVIDEQPLMFRSDAYHPDHFNCTHCGKELTAEAR---ELKGELYCLPCHDKMGVPICGA 224

  Fly    68 CRTPILERGVAAAERKWHEKCFRCVSCSKSLVSASFFEVNGYLFCKAHFRELFSSRCAGCEKPID 132
            ||.||..|.|.|..::||.:.|.|..|.|..:....:|..|..:|:.|:.:||...|..|...|:
Human   225 CRRPIEGRVVNALGKQWHVEHFVCAKCEKPFLGHRHYEKKGLAYCETHYNQLFGDVCYNCSHVIE 289

  Fly   133 RRAVVALSTKWHAKCFKCHHCRKRISAREFWIE-NGQPICAACQTVVP 179
            ...|.||:..|...||.|..|..:::.:..::| :.:|:|..|....|
Human   290 GDVVSALNKAWCVSCFSCSTCNSKLTLKNKFVEFDMKPVCKRCYEKFP 337

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG30178	NP_726395.1	LIM	6..61	CDD:295319	15/56 (27%)
		LIM	65..116	CDD:259829	18/50 (36%)
		LIM	124..171	CDD:295319	13/47 (28%)
LIMS2	NP_060450.2	LIM1_PINCH	39..97	CDD:188717
		LIM2_PINCH	100..151	CDD:188718
		LIM3_PINCH	164..214	CDD:188719	14/52 (27%)
		LIM4_PINCH	220..273	CDD:188720	18/52 (35%)
		LIM5_PINCH	281..334	CDD:188721	15/52 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1593918at2759
OrthoFinder	1	1.000	-	-		FOG0000055
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X39
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.920