DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG30178 and FHL2

DIOPT Version :9

Sequence 1:	NP_726395.1	Gene:	CG30178 / 246501	FlyBaseID:	FBgn0050178	Length:	187	Species:	Drosophila melanogaster
Sequence 2:	NP_001034581.1	Gene:	FHL2 / 2274	HGNCID:	3703	Length:	279	Species:	Homo sapiens

Alignment Length:	178	Identity:	55/178 - (30%)
Similarity:	81/178 - (45%)	Gaps:	6/178 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 ASICCRCNEKIWP--RAVCSLGKTYHPHHFTCKECGLVVDPKLFFAVDDDVVCSECYLDKHAARC 65
            :|.|..|.:.|.|  |.:...|.::|...|.|..|...:..|.|...|:...|..||..:||.:|
Human    98 SSKCQECKKTIMPGTRKMEYKGSSWHETCFICHRCQQPIGTKSFIPKDNQNFCVPCYEKQHAMQC 162

  Fly    66 SACRTPILERGVAAAERKWHEKCFRCVSCSKSLVSASFFEVNGYLFCKAHFRELFSSRCAGCEKP 130
            ..|:.||...||...|:.||::||.|.:|.|.|....|...:.:.:|...|.:|::.:||||..|
Human   163 VQCKKPITTGGVTYREQPWHKECFVCTACRKQLSGQRFTARDDFAYCLNCFCDLYAKKCAGCTNP 227

  Fly   131 ID----RRAVVALSTKWHAKCFKCHHCRKRISAREFWIENGQPICAAC 174
            |.    .:.:.....:||..||.|..|...:..|.|..|....:|..|
Human   228 ISGLGGTKYISFEERQWHNDCFNCKKCSLSLVGRGFLTERDDILCPDC 275

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG30178	NP_726395.1	LIM	6..61	CDD:295319	16/56 (29%)
		LIM	65..116	CDD:259829	17/50 (34%)
		LIM	124..171	CDD:295319	15/50 (30%)
FHL2	NP_001034581.1	LIM	<5..33	CDD:413332
		LIM1_FHL2	36..97	CDD:188806
		LIM2_FHL2	101..157	CDD:188810	16/55 (29%)
		LIM3_Fhl2	162..218	CDD:188815	19/55 (35%)
		LIM4_FHL2	221..278	CDD:188817	17/55 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	129	1.000	Inparanoid score	I4662
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000055
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X39
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.960