DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG30178 and FHL1

DIOPT Version :9

Sequence 1:	NP_726395.1	Gene:	CG30178 / 246501	FlyBaseID:	FBgn0050178	Length:	187	Species:	Drosophila melanogaster
Sequence 2:	XP_006724806.1	Gene:	FHL1 / 2273	HGNCID:	3702	Length:	339	Species:	Homo sapiens

Alignment Length:	199	Identity:	48/199 - (24%)
Similarity:	82/199 - (41%)	Gaps:	16/199 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 ASICCRCNEKIW--PRAVCSLGKTYHPHHFTCKECGLVVDPKLFFAVDDDVVCSECYLDKHAARC 65
            |:.|..|.:.|.  .:.|....:.:|...|.|.:|...:..:.|.|.|:.::|::|...:.:.:|
Human    53 ANTCVECRKPIGADSKEVHYKNRFWHDTCFRCAKCLHPLANETFVAKDNKILCNKCTTREDSPKC 117

  Fly    66 SACRTPIL--ERGVAAAERKWHEKCFRCVSCSKSLVSASFFEVNGYLFCKAHFRELFSSRCAGCE 128
            ..|...|:  ::.|......||:.||.|.:|.:.:.:.|||......:|.......|:..|..|.
Human   118 KGCFKAIVAGDQNVEYKGTVWHKDCFTCSNCKQVIGTGSFFPKGEDFYCVTCHETKFAKHCVKCN 182

  Fly   129 KPIDRRAVVALSTKWHAKCFKCHHCRKRISAREFWIENGQ------------PICAACQTVVPSP 181
            |.|....:......|||.||.|..|.|:::.:.|.....|            ..||.|:..:...
Human   183 KAITSGGITYQDQPWHADCFVCVTCSKKLAGQRFTAVEDQYYCVDCYKNFVAKKCAGCKNPITGK 247

  Fly   182 RNLS 185
            |.:|
Human   248 RTVS 251

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG30178	NP_726395.1	LIM	6..61	CDD:295319	13/56 (23%)
		LIM	65..116	CDD:259829	14/52 (27%)
		LIM	124..171	CDD:295319	14/58 (24%)
FHL1	XP_006724806.1	LIM	<21..49	CDD:413332
		LIM1_FHL1	56..109	CDD:188730	12/52 (23%)
		LIM2_FHL1	117..174	CDD:188808	14/56 (25%)
		LIM3_FHL1	178..230	CDD:188813	14/51 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	129	1.000	Inparanoid score	I4662
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000055
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X39
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.960