DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG30178 and LDB3

DIOPT Version :9

Sequence 1:	NP_726395.1	Gene:	CG30178 / 246501	FlyBaseID:	FBgn0050178	Length:	187	Species:	Drosophila melanogaster
Sequence 2:	NP_001165081.1	Gene:	LDB3 / 11155	HGNCID:	15710	Length:	732	Species:	Homo sapiens

Alignment Length:	169	Identity:	50/169 - (29%)
Similarity:	84/169 - (49%)	Gaps:	2/169 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 ICCRCNEKIWPRAVCSLGKTYHPHHFTCKECGLVVDPKLFFAVDDDVVCSECYLDKHAARCSACR 69
            :|..||..|....:.::|:::||..|||..|...:....|....::|.|..||....|..|:.|.
Human   555 LCGHCNNVIRGPFLVAMGRSWHPEEFTCAYCKTSLADVCFVEEQNNVYCERCYEQFFAPLCAKCN 619

  Fly    70 TPILERGVAAAERKWHEKCFRCVSCSKSLVSASFFEVNGYLFCKAHFRELFSSRCAGCEKPIDR- 133
            |.|:...:.|..:.||..||.|.:|.|...::.|...:|..:|:..:..|||::|.||:.|::.
Human   620 TKIMGEVMHALRQTWHTTCFVCAACKKPFGNSLFHMEDGEPYCEKDYINLFSTKCHGCDFPVEAG 684

  Fly   134 -RAVVALSTKWHAKCFKCHHCRKRISAREFWIENGQPIC 171
             :.:.||...||..||.|..|...:..:.|:.:..:|:|
Human   685 DKFIEALGHTWHDTCFICAVCHVNLEGQPFYSKKDRPLC 723

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG30178	NP_726395.1	LIM	6..61	CDD:295319	16/54 (30%)
		LIM	65..116	CDD:259829	15/50 (30%)
		LIM	124..171	CDD:295319	14/48 (29%)
LDB3	NP_001165081.1	PDZ_signaling	5..81	CDD:238492
		DUF4045	<77..180	CDD:330572
		ZM	189..214	CDD:128974
		DUF4749	263..353	CDD:318205
		Atrophin-1	<387..554	CDD:331285
		LIM1_ZASP_Cypher	556..607	CDD:188838	14/50 (28%)
		LIM2_Enigma_like	615..666	CDD:188748	15/50 (30%)
		LIM3_Enigma_like	674..727	CDD:188749	15/50 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1703
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000055
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.810