DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment NT5E-2 and NT5E

DIOPT Version :9

Sequence 1:	NP_611218.1	Gene:	NT5E-2 / 246458	FlyBaseID:	FBgn0050104	Length:	585	Species:	Drosophila melanogaster
Sequence 2:	NP_002517.1	Gene:	NT5E / 4907	HGNCID:	8021	Length:	574	Species:	Homo sapiens

Alignment Length:	567	Identity:	229/567 - (40%)
Similarity:	333/567 - (58%)	Gaps:	47/567 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    30 ATEFIILHNNDMHARFDQTSVNSGTCPPEDVHTNKCYGGFARVAHEVRKYRKEAQEGGTSVLYLN 94
            |.|..|||.||:|:|.:|||.:|..|    |:.::|.||.||:..:|::.|:    ...:||.|:
Human    26 AWELTILHTNDVHSRLEQTSEDSSKC----VNASRCMGGVARLFTKVQQIRR----AEPNVLLLD 82

  Fly    95 AGDTYTGTSWFTIFKDKIASAFLNKLKPDAISLGNHEFDERVEGLI-PFLNEVTFPVLACNLDLS 158
            |||.|.||.|||::|....:.|:|.|:.||::|||||||..||||| |.|.|..||:|:.|
Human    83 AGDQYQGTIWFTVYKGAEVAHFMNALRYDAMALGNHEFDNGVEGLIEPLLKEAKFPILSAN---- 143

  Fly   159 KVPQLKATWHLANS--------AILETNGTKVGVIGYLTPDTKKLT-LNMDVEFNEEVESINVEA 214
                :||...||:.        .:|......||::||.:.:|..|: ...::.|.:|:.::..|.
Human   144 ----IKAKGPLASQISGLYLPYKVLPVGDEVVGIVGYTSKETPFLSNPGTNLVFEDEITALQPEV 204

  Fly   215 KKLKAQGIKIIIALGHSGYLKDLEIAKNCPEVDIVIGGHTNTFLYTGAQPDAEHIDGPYPTMVKQ 279
            .|||...:..||||||||:..|..||:....||:|:|||:|||||||..|..|...|.||.:|..
Human   205 DKLKTLNVNKIIALGHSGFEMDKLIAQKVRGVDVVVGGHSNTFLYTGNPPSKEVPAGKYPFIVTS 269

  Fly   280 NSGKEVPVVQAYAYTKYLGKLHVQFDADGNLIQWDGSPILLNASVAQEQDLLDLLEVFRPNVTRL 344
            :.|::||||||||:.||||.|.::||..||:|...|:|||||:|:.::..:...:..:|..:...
Human   270 DDGRKVPVVQAYAFGKYLGYLKIEFDERGNVISSHGNPILLNSSIPEDPSIKADINKWRIKLDNY 334

  Fly   345 EKSVVGHTKVHLEGNKAVCRAEECNLGNLIADAMVFSRL--MEEQGGDFWTDAAISIMQGGGIRS 407
            ....:|.|.|:|:|:...||..|||:||||.|||:.:.|  .:|.   ||...::.|:.||||||
Human   335 STQELGKTIVYLDGSSQSCRFRECNMGNLICDAMINNNLRHTDEM---FWNHVSMCILNGGGIRS 396

  Fly   408 SIEKRSDGAITDNDILSVLPWGNKLYMVPMTGSTIRRALEHGAALRGKDSDGGFLQVSGIRVVFN 472
            .|::|::|.||..::.:|||:|....:|.:.|||:::|.||.....|: |.|.||||.||.||::
Human   397 PIDERNNGTITWENLAAVLPFGGTFDLVQLKGSTLKKAFEHSVHRYGQ-STGEFLQVGGIHVVYD 460

  Fly   473 SNKPEGQRVVSVQVRCAACRVPTYSDLNDTAIYNVVLGEFLLDGGDGHVM-------RDSAHQPQ 530
            .::..|.|||.:.|.|..||||:|..|....:|.|:|..||.:||||..|       .||..|
Human   461 LSRKPGDRVVKLDVLCTKCRVPSYDPLKMDEVYKVILPNFLANGGDGFQMIKDELLRHDSGDQ-- 523

  Fly   531 RLQNNDLEAVSQYLNQRDYVYPEIEGRIIFINASSTLMGSAALLLIS 577
                 |:..||.|:::...:||.:||||.| :..|...||.:|:.:|
Human   524 -----DINVVSTYISKMKVIYPAVEGRIKF-STGSHCHGSFSLIFLS 564

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
NT5E-2	NP_611218.1	MPP_CD73_N	33..320	CDD:277354	126/296 (43%)
		nadN	35..520	CDD:211667	206/496 (42%)
		5_nucleotid_C	348..519	CDD:280945	74/172 (43%)
NT5E	NP_002517.1	UshA	11..532	CDD:223808	216/532 (41%)
		MPP_CD73_N	29..310	CDD:277354	126/296 (43%)
		5_nucleotid_C	339..507	CDD:280945	74/171 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165158762
Domainoid	1	1.000	160	1.000	Domainoid score	I4045
eggNOG	1	0.900	-	-		E1_COG0737
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H1895
Inparanoid	1	1.050	399	1.000	Inparanoid score	I1945
Isobase	1	0.950	-	0	Normalized mean entropy	S6498
OMA	1	1.010	-	-		QHG52881
OrthoDB	1	1.010	-	-		D159192at33208
OrthoFinder	1	1.000	-	-		FOG0001036
OrthoInspector	1	1.000	-	-		otm40520
orthoMCL	1	0.900	-	-		OOG6_101038
Panther	1	1.100	-	-	LDO	PTHR11575
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1114
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.720