DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment NT5E-2 and veil

DIOPT Version :9

Sequence 1:	NP_611218.1	Gene:	NT5E-2 / 246458	FlyBaseID:	FBgn0050104	Length:	585	Species:	Drosophila melanogaster
Sequence 2:	NP_001286533.1	Gene:	veil / 36968	FlyBaseID:	FBgn0034225	Length:	599	Species:	Drosophila melanogaster

Alignment Length:	584	Identity:	371/584 - (63%)
Similarity:	458/584 - (78%)	Gaps:	13/584 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 VLAHWTRANPILSHPKVATEFIILHNNDMHARFDQTSVNSGTCPPEDVHTNKCYGGFARVAHEVR 77
            :|.|..:.|||....:||.||||||||||||||:||||.||||..|:.:|::|||||||||:|||
  Fly    17 LLIHPVQPNPIAPRAEVAAEFIILHNNDMHARFEQTSVTSGTCSKEEANTDQCYGGFARVAYEVR 81

  Fly    78 KYRKEAQEGGTSVLYLNAGDTYTGTSWFTIFKDKIASAFLNKLKPDAISLGNHEFDERVEGLIPF 142
            ||||||:||||.|.|||||||||||:|||::||||||||||||.||||||||||||:.||||:||
  Fly    82 KYRKEAEEGGTPVFYLNAGDTYTGTAWFTVYKDKIASAFLNKLSPDAISLGNHEFDQNVEGLVPF 146

  Fly   143 LNEVTFPVLACNLDLSKVPQLKATWHLANSAILETNGTKVGVIGYLTPDTKKLTLNMDVEFNEEV 207
            ||.|.||||||||:|:.||::.|...||||.|||.||.|||||||||||||.|.....||:.||:
  Fly   147 LNAVEFPVLACNLNLTDVPEMAAAKQLANSTILERNGVKVGVIGYLTPDTKVLAFRNKVEYEEEI 211

  Fly   208 ESINVEAKKLKAQGIKIIIALGHSGYLKDLEIAKNCPEVDIVIGGHTNTFLYTG---AQP---DA 266
            .|||.||.|||||||.||||||||||.||.|||.||||||||||||::|||...   |.|   |.
  Fly   212 VSINAEAAKLKAQGINIIIALGHSGYQKDQEIAMNCPEVDIVIGGHSHTFLDANQPVADPTDSDP 276

  Fly   267 EHIDGPYPTMVKQNSGKEVPVVQAYAYTKYLGKLHVQFDADGNLIQWDGSPILLNASVAQEQDLL 331
            |.:.|||||.|.|.|||:|||||||||||||||:||||||:||||::||:|||||||||||||||
  Fly   277 EAVRGPYPTTVVQASGKKVPVVQAYAYTKYLGKIHVQFDAEGNLIEFDGAPILLNASVAQEQDLL 341

  Fly   332 DLLEVFRPNVTRLEKSVVGHTKVHLEGNKAVCRAEECNLGNLIADAMVFSRLMEEQGGDFWTDAA 396
            |||:.:||.:..||.:|:|:|||.|||.. :||..|||||||:.|||::||::|.:||:||||.|
  Fly   342 DLLDEYRPKLDELENTVLGYTKVFLEGGN-ICRMRECNLGNLVTDAMIYSRVLENKGGEFWTDTA 405

  Fly   397 ISIMQGGGIRSSIEKRSDGAITDNDILSVLPWGNKLYMVPMTGSTIRRALEHGAALRGKDSDGGF 461
            |:.|||||||.|::|:.||.|....:|:|||:.|.||:..:.|||:..||||.|::|.:||:|||
  Fly   406 IAFMQGGGIRGSVDKKDDGVINGATLLAVLPFENNLYVTRILGSTLLAALEHSASVRLQDSNGGF 470

  Fly   462 LQVSGIRVVFNSNKPEGQRVVSVQVRCAACRVPTYSDLNDTAIYNVVLGEFLLDGGDGH-VMRDS 525
            ||:||:|||:|.|..:|:||||.|..||:|.||||..:|:||:|.|::.:|||:||||: ::.:|
  Fly   471 LQMSGLRVVYNYNNEQGKRVVSAQALCASCAVPTYKSINETALYQVIVPQFLLEGGDGYTLIEES 535

  Fly   526 AHQPQRLQNNDLEAVSQYLNQRDYVYPEIEGRIIF-----INASSTLMGSAALLLISSLLIKII 584
            ....:.:|.|||.|..:||.||.:||||||.||:.     ..::|.::.|.:|||:||||.:.|
  Fly   536 DPFTESMQRNDLNATMEYLKQRHFVYPEIEERIVIHEKADTGSASGIVASISLLLLSSLLTRFI 599

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
NT5E-2	NP_611218.1	MPP_CD73_N	33..320	CDD:277354	217/292 (74%)
		nadN	35..520	CDD:211667	332/490 (68%)
		5_nucleotid_C	348..519	CDD:280945	96/170 (56%)
veil	NP_001286533.1	UshA	14..556	CDD:223808	351/539 (65%)
		MPP_CD73_N	37..330	CDD:277354	217/292 (74%)
		5_nucleotid_C	358..528	CDD:280945	96/170 (56%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45468524
Domainoid	1	1.000	159	1.000	Domainoid score	I4048
eggNOG	1	0.900	-	-		E1_COG0737
Homologene	1	1.000	-	-		H1895
Inparanoid	1	1.050	411	1.000	Inparanoid score	I1830
Isobase	1	0.950	-	0	Normalized mean entropy	S6498
OMA	1	1.010	-	-		QHG52881
OrthoDB	1	1.010	-	-		D159192at33208
OrthoFinder	1	1.000	-	-		FOG0001036
OrthoInspector	1	1.000	-	-		otm26617
orthoMCL	1	0.900	-	-		OOG6_101038
Panther	1	1.100	-	-	P	PTHR11575
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5252
SonicParanoid	1	1.000	-	-		X1114
	15	14.790