DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment NT5E-2 and CG11883

DIOPT Version :9

Sequence 1:	NP_611218.1	Gene:	NT5E-2 / 246458	FlyBaseID:	FBgn0050104	Length:	585	Species:	Drosophila melanogaster
Sequence 2:	NP_001097260.1	Gene:	CG11883 / 36121	FlyBaseID:	FBgn0033538	Length:	792	Species:	Drosophila melanogaster

Alignment Length:	561	Identity:	124/561 - (22%)
Similarity:	229/561 - (40%)	Gaps:	113/561 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 VLAHWTRANPILSHPK-----------VATEFIILH-----NNDMHARFDQT----SVNSGTCPP 57
            :|...|||...:|.|:           |:...||.|     :..:.::.::|    .:..|...|
  Fly   151 LLTRPTRAYASVSQPQSPRHRGSGCGSVSGSRIITHGLTGRSTSISSQLEKTKKLLKMTEGEDKP 215

  Fly    58 EDV-HTNKCY-----------GGFARVAHEVRKYRKEAQEGGTSVLYLNAGDTYTGTSWFTIFKD 110
            ..: |.|..|           ||.||.|..::.:      ...:.|.|.:||.::.:...|..:.
  Fly   216 LTILHYNDVYNIESMAETEPVGGAARFATAIKSF------AHLNPLVLFSGDAFSPSMLSTFTQG 274

  Fly   111 KIASAFLNKLKPDAISLGNHEFDERVEGLIPFLNEVTFPVLACNLDLSKVPQLKATWHLANSAIL 175
            :.....||.:.......|||:||..::.|:..:.:..||                 |.::|....
  Fly   275 EQMIPVLNTVGTHCAVFGNHDFDHGLDVLVKLIKQTEFP-----------------WLMSNVVDN 322

  Fly   176 ET---------------NGTKVGVIGYLTPDTKKLTLNMD---VEFNEEVESINVEAKKLKAQGI 222
            ||               |...:|:||.:..:..:....:|   |.:.:.||:.|..|::|:.:|.
  Fly   323 ETGRPLGGGKISHFILHNQISIGLIGLVEREWLETLPTIDPNEVTYIDYVEAGNKLARELRNEGC 387

  Fly   223 KIIIALGHSGYLKDLEIAKNCPEVDIVIGGHTNTFLYTGAQPDAEHIDGPYPTMVKQNSGKEVPV 287
            .:||||.|.....|:.:|:.|..:||::|||             :|:     ..|.:.:||  .:
  Fly   388 DLIIALTHMRTPNDINLAEKCNGIDIILGGH-------------DHV-----REVTEINGK--MI 432

  Fly   288 VQAYAYTKYLGKLHVQFD-ADGNLIQWDGSPILLNASVAQEQDLLDLLEVFRPNVTRLEKSVVGH 351
            |::....:....:.::.| |:......|.....:.|.:.::.:|...|..:...:......|:|.
  Fly   433 VKSGTDFQQFSVITIERDAANREHFTTDVKCFDVTAKIPEDPELKQELSKYAKFIESKLSDVMGV 497

  Fly   352 TKVHLEGNKAVCRAEECNLGNLIADAMVFSRLMEEQGGDFWTDAAISIMQGGGIRSSIEKRSDGA 416
            ..|.|:|..:..|.:|.||||.:.|.::.:           ..|.:.|:.||..||. .....||
  Fly   498 FSVELDGRFSRVRTQETNLGNWVCDVVLAA-----------VGADVVILNGGTFRSD-RVHPVGA 550

  Fly   417 ITDNDILSVLPWGNKLYMVPMTGSTIRRALEHGAALRGKDSDGGFLQVSGIRVVFNSNKPEGQRV 481
            .|..|:::|:|..:.|.::.:.|..:.:|||:|.:...| .:|.|.|||||...|:.....|:|:
  Fly   551 FTMGDLVNVIPMRDPLILLEVKGKILWQALENGVSAYPK-LEGRFPQVSGISFAFDPQAEPGKRI 614

  Fly   482 VSVQVRCAACRVPTYSDLNDTAIYNVVLGEFLLDGGDGHVM 522
            ....::..    ..|.:|..:  |.:.:..::..|.||:.|
  Fly   615 DPQLIQVG----DEYLNLEQS--YKLCVKSYIFMGCDGYTM 649

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
NT5E-2	NP_611218.1	MPP_CD73_N	33..320	CDD:277354	66/326 (20%)
		nadN	35..520	CDD:211667	114/524 (22%)
		5_nucleotid_C	348..519	CDD:280945	45/170 (26%)
CG11883	NP_001097260.1	UshA	202..661	CDD:223808	114/510 (22%)
		MPP_CG11883_N	216..473	CDD:277351	61/299 (20%)
		5_nucleotid_C	494..646	CDD:280945	45/170 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45468533
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0737
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001036
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.740