DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG30095 and NLGN2

DIOPT Version :9

Sequence 1:	NP_725529.1	Gene:	CG30095 / 246453	FlyBaseID:	FBgn0050095	Length:	214	Species:	Drosophila melanogaster
Sequence 2:	NP_065846.1	Gene:	NLGN2 / 57555	HGNCID:	14290	Length:	835	Species:	Homo sapiens

Alignment Length:	152	Identity:	33/152 - (21%)
Similarity:	51/152 - (33%)	Gaps:	54/152 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly    79 AKGKWP--YVPGFMKYRVDNAARSFFNQNDSFIKQFCTKWIQVKECF-----RPLFDKSNN---- 132
            |...|.  |.|  :||....||:...::.||         .:..||.     |.|.|:...
Human   294 AISSWSVNYQP--LKYTRLLAAKVGCDREDS---------AEAVECLRRKPSRELVDQDVQPARY 347

  Fly   133 -------TDVEVETLDAKI---QGQRCNCDKLL--------------LSTEPPVPVVYFD---KN 170
                   .|.:|...|.:|   ||:..|.|.|:              ..:|..|....||   .|
Human   348 HIAFGPVVDGDVVPDDPEILMQQGEFLNYDMLIGVNQGEGLKFVEDSAESEDGVSASAFDFTVSN 412

  Fly   171 YIGNV-----SSETILNTIEFL 187
            ::.|:     ..:.:..||:|:
Human   413 FVDNLYGYPEGKDVLRETIKFM 434

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG30095	NP_725529.1	None
NLGN2	NP_065846.1	COesterase	41..601	CDD:278561	33/152 (22%)
		Aes	<170..>268	CDD:223730
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	623..668
		Required for interaction with LHFPL4. /evidence=ECO:0000250\|UniProtKB:Q69ZK9	678..698
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	790..835
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900