Protein Alignment CG30091 and TMPRSS9

DIOPT Version :10

• Sequence 1: NP_725484.1
• Gene: CG30091 / 246449
• FlyBaseID: FBgn0050091
• Length: 526
• Species: Drosophila melanogaster
• Sequence 2: NP_001382442.1
• Gene: TMPRSS9 / 360200
• HGNCID: 30079
• Length: 1093
• Species: Homo sapiens
• Alignment Length: 633
• Identity: 146/633 - (23%)
• Similarity: 225/633 - (35%)
• Gaps: 196/633 - (30%)

  Fly    25 EDCGV--PMQLIPKIVGGVDAGELKNPWMALIKTNDEFICGGSVITNKFVLTAAHCMCTDEECIV 87
            ::||.  .|:...::|||..|...:.||...:|......||.:|:.::::|:||||...     .
Human   524 QECGARPAMEKPTRVVGGFGAASGEVPWQVSLKEGSRHFCGATVVGDRWLLSAAHCFNH-----T 583

  Fly    88 KYTQLTVTLGVYHLLATGEHNHPHEIYNVERVYIHDSF--AIQNYRNDIALLRLQKSIVYKPQIK 150
            |..|:...||...||..|  ..|.:| .:.||.:|..:  .|.::  |:|:|.|...:.:...|:
Human   584 KVEQVRAHLGTASLLGLG--GSPVKI-GLRRVVLHPLYNPGILDF--DLAVLELASPLAFNKYIQ 643

  Fly   151 PLCILLNDQLKPQTDLIQEFTA------IGWGVT--GNGKMSNNLQMVKIYRIDRKMCEAAFWYT 207
            |:|:.|         .||:|..      .|||.|  ||......||...:..||:|.|...:.::
Human   644 PVCLPL---------AIQKFPVGRKCMISGWGNTQEGNATKPELLQKASVGIIDQKTCSVLYNFS 699

  Fly   208 FDYPMFCAGTAVGR-DTCKRDSGGPL---------YIHMLFDGIKRATQLGIVS--TGTEDCRGF 260
            ....|.|||...|: |:|:.||||||         |:            .||||  .|....:..
Human   700 LTDRMICAGFLEGKVDSCQGDSGGPLACEEAPGVFYL------------AGIVSWGIGCAQVKKP 752

  Fly   261 GMYTDVMGHIDFIERIVLDADIEVVLPYIDLLDA-----------------------------GC 296
            |:||.:.....:|..|:....:.:..|....:.|                             |.
Human   753 GVYTRITRLKGWILEIMSSQPLPMSPPSTTRMLATTSPRTTAGLTVPGATPSRPTPGAASRVTGQ 817

  Fly   297 LGNDTLNSWDRSG------PDAIRS-----------------------------FEWLAEVYKDS 326
            ..|.||::...:.      |||..:                             :.|...::...
Human   818 PANSTLSAVSTTARGQTPFPDAPEATTHTQLPDCGLAPAALTRIVGGSAAGRGEWPWQVSLWLRR 882

  Fly   327 FIISNGALISKTFVVTTAQLISESTALKVQLGQGDVHTYA-----------------VASVHKHP 374
            .....||::     |....|:|.:....|   .||...:|                 ||.::|||
Human   883 REHRCGAVL-----VAERWLLSAAHCFDV---YGDPKQWAAFLGTPFLSGAEGQLERVARIYKHP 939

  Fly   375 KFVSL--AQNDIALLKLGEEVQYTESIRPICLPSLSNKAEQQKFQRRAADPA------LNLIAVG 431
             |.:|  ...|:|||:|...|:.:..:||||||                :||      ...:..|
Human   940 -FYNLYTLDYDVALLELAGPVRRSRLVRPICLP----------------EPAPRPPDGTRCVITG 987

  Fly   432 WGTP----------TNVVVRRTNASKCYREDHQDIGEQQLCMESPSPHLLRVGI-------GSPL 479
            ||:.          ....||..:...|.|.....|..:.||...|     :.|:       |.||
Human   988 WGSVREGGSMARQLQKAAVRLLSEQTCRRFYPVQISSRMLCAGFP-----QGGVDSCSGDAGGPL 1047

  Fly   480 VNPLTHGNRRAFSLVGLAS--FGRLEPFASNVYTNVLEYLDWIGEMVK 525
            ......|.   :.|.|:.|  :|...|....|||.|.....|||:.::
Human  1048 ACREPSGR---WVLTGVTSWGYGCGRPHFPGVYTRVAAVRGWIGQHIQ 1092

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG30091	NP_725484.1	Tryp_SPc	36..273	CDD:214473	73/258 (28%)
		Tryp_SPc	332..520	CDD:473915	55/231 (24%)
TMPRSS9	NP_001382442.1	SEA	66..>127	CDD:460188
		LDLa	188..223	CDD:238060
		Tryp_SPc	236..465	CDD:214473
		Tryp_SPc	538..768	CDD:238113	74/260 (28%)
		Pneumo_att_G	<717..>867	CDD:114270	27/161 (17%)
		Tryp_SPc	861..1087	CDD:238113	56/258 (22%)