DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG30091 and Prss53

DIOPT Version :9

Sequence 1:	NP_725484.1	Gene:	CG30091 / 246449	FlyBaseID:	FBgn0050091	Length:	526	Species:	Drosophila melanogaster
Sequence 2:	NP_001074737.1	Gene:	Prss53 / 330657	MGIID:	2652890	Length:	552	Species:	Mus musculus

Alignment Length:	543	Identity:	129/543 - (23%)
Similarity:	198/543 - (36%)	Gaps:	136/543 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    49 PWMALIKTNDEFICGGSVITNKFVLTAAHCMCTDEECIVKYTQLTVTLGVYHLLATGEHNHPHEI 113
            ||.|.::.....||.||::.:.:|||||||.  ::....:.:..:|.||  .|...|:.....|:
Mouse    49 PWQASVRRQGVHICSGSLVADTWVLTAAHCF--EKMATAELSSWSVVLG--SLKQEGQSPGAEEV 109

  Fly   114 ----YNVERVYIHDSFAIQNYRNDIALLRLQKSIVYKPQIKPLCILLNDQLKPQTDLIQEFTAIG 174
                ..:.:.|.|.|     ..:|:|||:|....|.    ..||:       ||......|.|..
Mouse   110 GVAALQLPKAYNHYS-----QGSDLALLQLTHPTVQ----TTLCL-------PQPTYHFPFGASC 158

  Fly   175 WGVTG----NGKMSNNLQMVKIYRIDRKMCEAAF----WYTFDYP----MFCAGTAVG-RDTCKR 226
            | .||    ...:|..|:.:::..|.|..|...:    ......|    |.|.|...| :..|:.
Mouse   159 W-ATGWDQNTSDVSRTLRNLRLRLISRPTCNCLYNRLHQRLLSNPARPGMLCGGAQPGEQGPCQG 222

  Fly   227 DSGGPLYIHMLFDGIKRATQLGIVSTGTEDCRGFG---MYTDVMGHIDFIERIVLDADIEVVLPY 288
            |||||:   |..:......|:||:|. |..|....   :.||:..|..:::..|.:|...|..|.
Mouse   223 DSGGPV---MCREPDGHWVQVGIISF-TSKCAQEDTPVLLTDMAVHSSWLQAHVHEAAFLVQAPG 283

  Fly   289 IDLL--DAGCLGNDTLNSWDRSGPD--AIRSFEWLAEVYKDSFIISNGALISKTFVVTTAQLISE 349
            :..:  :..|:...:|.|   :||.  |:..:.|.|.:.....:...|||:|:..|:|.|.....
Mouse   284 VVKMSDENSCVACGSLRS---AGPQAGALSQWPWDARLKHHGKLACGGALVSEVVVLTAAHCFIG 345

  Fly   350 STALK---VQLGQG----DVHTYAVASVHKHPKFVSLAQNDIALLKLGEEVQYTESIRPICLP-- 405
            ...|:   |.||.|    .:....:...:.||:    ...|:|.|.|.:.|.....:||:|||
Mouse   346 RQTLEEWSVGLGAGPEEWGLKQLILHGAYTHPE----GGYDVAFLLLAQPVTLGPGLRPLCLPYA 406

  Fly   406 -------------SLSNKAEQQKFQRRAADPALNLIAVGWGTPTNVVVRRTNASKCYREDHQDIG 457
                         .|:.||                   |...|..|.|.......|.|:
Mouse   407 DHHLPDGEHGWVLGLTQKA-------------------GINYPQTVPVTVLGPMACSRQ------ 446

  Fly   458 EQQLCMESPSPHLLRVGIGSPLV--------------------NPLTHGNRRAFSLVGLASFGRL 502
                       |....|.|.|::                    .||.|..|..:.||||.|||..
Mouse   447 -----------HAAPGGTGIPILPGMVCTTVVGEPPHCEGLSGAPLVHEIRGTWFLVGLHSFGDT 500

  Fly   503 EPFASN--VYTNVLEYLDWIGEM 523
            ...::.  |:..:..|.|||..:
Mouse   501 CQSSAKPAVFAALSAYEDWISNL 523

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG30091	NP_725484.1	Tryp_SPc	36..273	CDD:214473	64/243 (26%)
		Tryp_SPc	37..276	CDD:238113	64/246 (26%)
		Trypsin	310..520	CDD:278516	55/255 (22%)
		Tryp_SPc	313..520	CDD:304450	53/250 (21%)
Prss53	NP_001074737.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	27..46
		Tryp_SPc	45..271	CDD:238113	64/246 (26%)
		Tryp_SPc	311..522	CDD:238113	55/250 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910