DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG30091 and CG30187

DIOPT Version :9

Sequence 1:	NP_725484.1	Gene:	CG30091 / 246449	FlyBaseID:	FBgn0050091	Length:	526	Species:	Drosophila melanogaster
Sequence 2:	NP_001246475.2	Gene:	CG30187 / 246509	FlyBaseID:	FBgn0050187	Length:	500	Species:	Drosophila melanogaster

Alignment Length:	553	Identity:	173/553 - (31%)
Similarity:	261/553 - (47%)	Gaps:	91/553 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 AWVVLFAWMLTAGRGSARLLDEDCGVPMQLIPKIVGGVDAGELKNPWMALIKTNDEFICGGSVIT 68
            ||:.:..|.| ...|::..||:.||:.:.|  ||.||.:|....:.|||.:.....|||||::|.
  Fly     6 AWIPVIFWFL-KDVGASIFLDQICGINIAL--KITGGHNAAFQNSVWMAAVHNRTHFICGGTLIH 67

  Fly    69 NKFVLTAAHCMCTDEECIVKYTQLTVTLGVYHLLATGEHNHPHEIYNVERVYIHDSFAIQ-NYRN 132
            .:|||||||       |||.....:|:||.|:      .:.|.:..:|....:|.||.:: :|.|
  Fly    68 KRFVLTAAH-------CIVDQDVQSVSLGAYN------KSDPADRKDVITAVVHSSFDVRASYEN 119

  Fly   133 DIALLRLQKSIVYKPQIKPLCILLNDQLKPQTDLIQEFTAIGWGVTGNGKMSNNLQMVKIYRIDR 197
            ||.||:|...:::...|:|:||:||..:......::.|.|.|||.....|.|:.||.:.:..:||
  Fly   120 DIGLLKLSSDVIFNALIRPICIVLNKSMANHMRNMRTFKAFGWGTLRGNKTSDILQTIILNHLDR 184

  Fly   198 KMCEAAFWYTFDYP---MFCAGTAVGRDTCKRDSGGPLYIHMLFDGI-KRATQLGIVSTGTEDCR 258
            :.|   :.....||   ..|||...| |||..||||||...:...|| .|..|.||:|.|...|.
  Fly   185 EEC---YMELSVYPSEKQICAGVPSG-DTCGGDSGGPLTNDVFIQGIGNREVQFGIISVGKTSCD 245

  Fly   259 GFGMYTDVMGHIDF----IERIVLD-----ADIEVVLP-------YIDLLDAGCLGN-DTLNSWD 306
            |.|:|||:|...|:    |||:.::     |....::|       |.|...|....| :.|..|
  Fly   246 GQGVYTDLMSFADWIKMTIERLSIEDEPQSAPFYKIIPQQQDVFLYNDCGGANIAANLEALIRW- 309

  Fly   307 RSGPDAIRSFEWLAEVYKDSFIISNGALISKTFVVTTAQLISE-STALKVQLGQGDVHTYAVASV 370
                    |..|           :.|..::..||:|.|:.:.| |:.|:|.| :|....|.:.||
  Fly   310 --------SIFW-----------TRGIFVTHQFVLTNAKRLPENSSNLQVYL-KGRTQFYGMYSV 354

  Fly   371 H-KHPKFVSLAQNDIALLKLGEEVQYTESIRPICLPSLSNKAEQQKFQRRAADPALNLI--AVGW 432
            . ..|.    .|||:|||||...|...:..:|||:  |:|..:|   ||.|:.|...:.  |...
  Fly   355 FGVFPN----DQNDVALLKLNRPVTGPDGFKPICM--LANVVDQ---QRAASTPPFTMFFEAPDN 410

  Fly   433 GTPTNVVVRRTNASKCYREDHQDIGEQQLCMESPSPHLLRVG-IGSPLV-NPLTHGNRRAFSLVG 495
            ||..::.|...|..:|.....:.:...|||:|.|    ..:| |||.:: ..:|:..:....|.|
  Fly   411 GTIYDISVALGNPYQCSGRIQRRVEWNQLCVEHP----YGMGFIGSYILGRKVTNSGKTWLVLFG 471

  Fly   496 LASFGRLEPFASN---VYTNVLEYLDWIGEMVK 525
            :.|      .:||   |:|||::..:||...::
  Fly   472 IVS------DSSNGVYVFTNVMKLSEWIANTIR 498

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG30091	NP_725484.1	Tryp_SPc	36..273	CDD:214473	89/245 (36%)
		Tryp_SPc	37..276	CDD:238113	90/247 (36%)
		Trypsin	310..520	CDD:278516	61/218 (28%)
		Tryp_SPc	313..520	CDD:304450	61/215 (28%)
CG30187	NP_001246475.2	Tryp_SPc	35..260	CDD:214473	89/241 (37%)
CG30187	NP_001246475.2	Trypsin	316..>384	CDD:355628	25/72 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	102	1.000	Domainoid score	I4289
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	141	1.000	Inparanoid score	I4468
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000404
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_108863
Panther	1	1.100	-	-	P	PTHR24260
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	6	5.960