DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG30091 and CG42694

DIOPT Version :9

Sequence 1:	NP_725484.1	Gene:	CG30091 / 246449	FlyBaseID:	FBgn0050091	Length:	526	Species:	Drosophila melanogaster
Sequence 2:	NP_001188994.1	Gene:	CG42694 / 10178792	FlyBaseID:	FBgn0261584	Length:	512	Species:	Drosophila melanogaster

Alignment Length:	569	Identity:	164/569 - (28%)
Similarity:	250/569 - (43%)	Gaps:	114/569 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 LFAW--MLTA--GRGSARLLDEDCGVPM--QLIPKIVGGVDAGELKNP---WMALIKTNDEFICG 63
            ||||  |||.  ...:::.||:.||.|:  |.|.|         |:.|   |:|.|......:|.
  Fly     4 LFAWLLMLTVLQSHVNSKFLDDYCGAPISNQSITK---------LRQPQAGWLAHISNGTHVLCS 59

  Fly    64 GSVITNKFVLTAAHCMCTDEECIVKYTQLTVTLGVYHLLATGEHNHPHEIYNVERVYIHDSFAIQ 128
            ||:|:.:|||:||       :||..:.:|.|.|||.:  ||   ..|| .|.|..|.| .|.:.:
  Fly    60 GSLISKQFVLSAA-------QCIDVHGKLFVQLGVSN--AT---KSPH-WYTVSNVVI-PSHSGK 110

  Fly   129 NYRNDIALLRLQKSIVYKPQIKPLCILLNDQLKPQTDLIQEFTAIGWGVTGNGKMSNNLQMVKIY 193
            ..:.||.||:|.:|:.|...:.|:||.||........::|.||...| ::.|    .|.|.:.:.
  Fly   111 RLQRDIGLLKLSQSVDYNDFVYPICIALNTNTLDMVKILQNFTTSAW-LSKN----KNPQTIVLS 170

  Fly   194 RIDRKMCEAAFWYTFDYPMFCAGTAVGRDTCKRDSGGPL----------YIHMLFDGIKRATQLG 248
            ::.|..|:............||.:....::|..|||..|          ...||| ||:     |
  Fly   171 QLSRDRCKLNLSGNVTPKEICAASLQRNNSCFIDSGSALTQPIIQGSNIVREMLF-GIR-----G 229

  Fly   249 IVSTGTEDCRGFGMYTDVMGHIDFIERIVLDAD----IEVVLPYID--------------LLDAG 295
            .|: |...|....:|.||...:.:||.:|...|    ..|..|.::              ||...
  Fly   230 YVN-GRSWCSEPAIYIDVAECVGWIETVVQQYDGTDSRAVATPEVNQHLKHSLSRMGKNILLFKN 293

  Fly   296 CLGNDTLNSWDRSGPDAIRSFEWLAEVYKDSFIISNGALISKTFVVTTAQLISEST-ALKVQLGQ 359
            |.|| :|.|..|            |.:|..:: |..|..|:..||:|.|:.:.||. :|.|.| .
  Fly   294 CRGN-SLQSKLR------------ARIYGPNY-IGQGWFITHRFVITNAKDLPESAESLYVGL-P 343

  Fly   360 GDVHTY---AVASVHKHPKFVSLAQNDIALLKLGEEVQYTESIRPICLPSLSNKAEQQKFQRRAA 421
            |.:.:|   :|.||.|||:|....:||||||::.:.|.... :||||:....|:.|..|     :
  Fly   344 GTLRSYDEFSVQSVFKHPEFSEDYKNDIALLRVHQRVAMGH-LRPICMLLKENQQELAK-----S 402

  Fly   422 DPALNLIAVGWGTPTNV-VVRRTNASK----CYREDHQDIGEQQLCM----ESPSPHLLRVGIGS 477
            .|.::...|  .|...: |||:.:|..    |.....:.|...|||:    |:...:..|.||
  Fly   403 SPPISFDYV--QTANRIQVVRKIDALADPRICTNRLLKTIEPNQLCVVVPPETVQKNATRGGI-- 463

  Fly   478 PLVNPLTHGNRRAFSLVGLASFGRLEPFASNVYTNVLEYLDWIGEMVKA 526
             |...:.:..:....|.|::|:...:   ..|:|||:|:..||..:|.:
  Fly   464 -LGLRMMYSGKEWLILFGISSYSHND---IEVFTNVMEHTQWIANVVNS 508

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG30091	NP_725484.1	Tryp_SPc	36..273	CDD:214473	71/249 (29%)
		Tryp_SPc	37..276	CDD:238113	72/251 (29%)
		Trypsin	310..520	CDD:278516	62/222 (28%)
		Tryp_SPc	313..520	CDD:304450	62/219 (28%)
CG42694	NP_001188994.1	Tryp_SPc	46..256	CDD:304450	70/235 (30%)
		Tryp_SPc	46..253	CDD:214473	68/232 (29%)
		Tryp_SPc	319..505	CDD:304450	60/200 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45463412
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000404
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_108863
Panther	1	1.100	-	-	P	PTHR24260
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	5	4.840