Protein Alignment Erasp and TMPRSS3

DIOPT Version :10

• Sequence 1: NP_725487.1
• Gene: Erasp / 246448
• FlyBaseID: FBgn0050090
• Length: 291
• Species: Drosophila melanogaster
• Sequence 2: NP_076927.1
• Gene: TMPRSS3 / 64699
• HGNCID: 11877
• Length: 454
• Species: Homo sapiens
• Alignment Length: 293
• Identity: 85/293 - (29%)
• Similarity: 130/293 - (44%)
• Gaps: 56/293 - (19%)

  Fly     8 ITALAIGVLCSLG--NGEYLEPRCGLTANTIAF--KIIGGRDAIINSNPWMAYIHSSVKLICGGT 68
            :|||...|....|  :|..:..:|....:...:  :|:||..::::..||.|.:......:|||:
Human   181 VTALHHSVYVREGCASGHVVTLQCTACGHRRGYSSRIVGGNMSLLSQWPWQASLQFQGYHLCGGS 245

  Fly    69 LITQRFVLTAAHCVNEGSAVKVRLGEYDDTATEDCNSKICIPR---------------AEEHDVD 118
            :||..:::||||||            ||          :.:|:               |..|.|:
Human   246 VITPLWIITAAHCV------------YD----------LYLPKSWTIQVGLVSLLDNPAPSHLVE 288

  Fly   119 MAFRHGKFSEIKNLNDIALLRLAKFVTFKAHISPICIILGTSKRELVD-SIEWFVATGWGETR-- 180
            ....|.|:...:..|||||::||..:||...|.|:|  |..|:....| .:.|  .:|||.|.
Human   289 KIVYHSKYKPKRLGNDIALMKLAGPLTFNEMIQPVC--LPNSEENFPDGKVCW--TSGWGATEDG 349

  Fly   181 THRTRGVLQITQLQRYNSSQC--MQALGRLVQQNQICAGRL--GSDTCNGDSGGPLFQTVRHMDK 241
            ......||....:...::..|  ....|.::..:.:|||.|  |.|:|.|||||||....|.:.|
Human   350 AGDASPVLNHAAVPLISNKICNHRDVYGGIISPSMLCAGYLTGGVDSCQGDSGGPLVCQERRLWK 414

  Fly   242 M-RPVQFGVVSYGSRECSGIGVYTDVYSYADWI 273
            : ....||:   |..|.:..||||.|.|:.|||
Human   415 LVGATSFGI---GCAEVNKPGVYTRVTSFLDWI 444

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Erasp	NP_725487.1	Tryp_SPc	40..276	CDD:238113	78/257 (30%)
TMPRSS3	NP_076927.1	LDLa	74..107	CDD:238060
		SRCR_2	112..210	CDD:464747	7/28 (25%)
		Tryp_SPc	216..444	CDD:214473	76/256 (30%)