Protein Alignment Erasp and TMPRSS4

DIOPT Version :10

• Sequence 1: NP_725487.1
• Gene: Erasp / 246448
• FlyBaseID: FBgn0050090
• Length: 291
• Species: Drosophila melanogaster
• Sequence 2: XP_005271670.1
• Gene: TMPRSS4 / 56649
• HGNCID: 11878
• Length: 494
• Species: Homo sapiens
• Alignment Length: 318
• Identity: 94/318 - (29%)
• Similarity: 146/318 - (45%)
• Gaps: 77/318 - (24%)

  Fly     3 GAIAAITALAIGVLCSLGNGEYLEPRCGLTANTIAFKIIGGRDAIINSNPWMAYIHSSVKLICGG 67
            |::.::..||                ||.:..|.  :::|..:|.::|.||...|....:.:|||
Human   186 GSLVSLHCLA----------------CGKSLKTP--RVVGVEEASVDSWPWQVSIQYDKQHVCGG 232

  Fly    68 TLITQRFVLTAAHCVNEGSAV---KVR-----LGEYDDTATEDCNSKICIPRAEEHDVDMAFRHG 124
            :::...:|||||||..:.:.|   |||     ||.:...|.    :||.|       ::....:.
Human   233 SILDPHWVLTAAHCFRKHTDVFNWKVRAGSDKLGSFPSLAV----AKIII-------IEFNPMYP 286

  Fly   125 KFSEIKNLNDIALLRLAKFVTFKAHISPICIILGTSKRELVDSIE-WFVATGWGETRTH--RTRG 186
            |.      |||||::|...:||...:.|||  |.....||..:.. |.:  |||.|:.:  :...
Human   287 KD------NDIALMKLQFPLTFSGTVRPIC--LPFFDEELTPATPLWII--GWGFTKQNGGKMSD 341

  Fly   187 VLQITQLQRYNSSQCM--QALGRLVQQNQICAG--RLGSDTCNGDSGGPL-FQTVRHMDKMRPVQ 246
            :|....:|..:|::|.  .|....|.:..:|||  ..|.|||.||||||| :|:    |:...|
Human   342 ILLQASVQVIDSTRCNADDAYQGEVTEKMMCAGIPEGGVDTCQGDSGGPLMYQS----DQWHVV- 401

  Fly   247 FGVVSYGSRECSG---IGVYTDVYSYADWIATV-----VQQNTHVPA-------PIMP 289
             |:||:| ..|.|   .||||.|.:|.:||..|     :|::.:.|.       |.:|
Human   402 -GIVSWG-YGCGGPSTPGVYTKVSAYLNWIYNVWKDRTIQRSCNSPGTGLVIQQPAVP 457

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Erasp	NP_725487.1	Tryp_SPc	40..276	CDD:238113	83/254 (33%)
TMPRSS4	XP_005271670.1	LDLa	58..92	CDD:238060
		SRCR_2	108..197	CDD:470597	3/26 (12%)
		Tryp_SPc	204..429	CDD:214473	81/252 (32%)