Protein Alignment CG30088 and PLAT

DIOPT Version :10

• Sequence 1: NP_725488.3
• Gene: CG30088 / 246447
• FlyBaseID: FBgn0050088
• Length: 281
• Species: Drosophila melanogaster
• Sequence 2: NP_000921.1
• Gene: PLAT / 5327
• HGNCID: 9051
• Length: 562
• Species: Homo sapiens
• Alignment Length: 281
• Identity: 92/281 - (32%)
• Similarity: 131/281 - (46%)
• Gaps: 53/281 - (18%)

  Fly    30 IPS---CGVSYESNVATRIVRGKEAMLKSAPFMAYLYY------SSEIHCGGTIISSRYILTAAH 85
            :||   ||:...|....||..|..|.:.|.|:.|.::.      .....|||.:|||.:||:|||
Human   293 VPSCSTCGLRQYSQPQFRIKGGLFADIASHPWQAAIFAKHRRSPGERFLCGGILISSCWILSAAH 357

  Fly    86 CMRP-----YLKVRLGE-HDITRNPDCQGGSCSPPAEE---FDIVLATKYKRF-DRFLANDIALL 140
            |.:.     :|.|.||. :.:.            |.||   |::.....:|.| |....||||||
Human   358 CFQERFPPHHLTVILGRTYRVV------------PGEEEQKFEVEKYIVHKEFDDDTYDNDIALL 410

  Fly   141 KL----SRNIRFNVHIQPICLILNPAAAPNVHEFQAFGWGQTE--TNHSANVLQTTVLTRYDNRH 199
            :|    ||..:.:..::.:||.......|:..|.:..|:|:.|  :...:..|:...:..|.:..
Human   411 QLKSDSSRCAQESSVVRTVCLPPADLQLPDWTECELSGYGKHEALSPFYSERLKEAHVRLYPSSR 475

  Fly   200 CRS--VLSMPITINQLCVGFQGS--------DTCSGDSGGPLVTKVNYDGVWRYLQLGIVSFGDD 254
            |.|  :|:..:|.|.||.|...|        |.|.||||||||. :| ||  |...:||:|:|..
Human   476 CTSQHLLNRTVTDNMLCAGDTRSGGPQANLHDACQGDSGGPLVC-LN-DG--RMTLVGIISWGLG 536

  Fly   255 KCQS--PGVYTYVPNYIRWIR 273
            ..|.  |||||.|.||:.|||
Human   537 CGQKDVPGVYTKVTNYLDWIR 557

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG30088	NP_725488.3	Tryp_SPc	45..273	CDD:238113	84/261 (32%)
PLAT	NP_000921.1	FN1	41..83	CDD:214494
		Important for binding to annexin A2	42..52
		EGF	86..117	CDD:394967
		KR	125..209	CDD:238056
		Kringle	215..296	CDD:395005	1/2 (50%)
		Tryp_SPc	313..559	CDD:238113	85/261 (33%)