DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Rif1 and RIF1

DIOPT Version :9

Sequence 1:	NP_725497.1	Gene:	Rif1 / 246445	FlyBaseID:	FBgn0050085	Length:	1416	Species:	Drosophila melanogaster
Sequence 2:	NP_060621.3	Gene:	RIF1 / 55183	HGNCID:	23207	Length:	2472	Species:	Homo sapiens

Alignment Length:	1676	Identity:	316/1676 - (18%)
Similarity:	575/1676 - (34%)	Gaps:	489/1676 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    62 WLGDILPLMFDADRKIQDCAVAALAEALVALDVSVIHSAKCWPQIRSEFVDKYTIIIGEMRD--- 123
            |...::||:..:.:|:......||...:..|.......|....|:.:      |.:|.|::.
Human   184 WAKLVIPLVVHSAQKVHLRGATALEMGMPLLLQKQQEIASITEQLMT------TKLISELQKLFM 242

  Fly   124 AKNSNW-HKIWTLLVQIMDEDLLRGCVYINKFLALVELGFRNPDNGVRSEAFLCWRVLIKIFAAY 187
            :||..: .|:|.|.|:::...|.|...:||..|.|.|||||:....::..||:.|:.||..||..
Human   243 SKNETYVLKLWPLFVKLLGRTLHRSGSFINSLLQLEELGFRSGAPMIKKIAFIAWKSLIDNFALN 307

  Fly   188 -DELTSAKRLRLLLIPLRTSQSRSSHVSGIKLRVWWYLLSCLDHELPKSFDSA----VEHFLAFM 247
             |.|.|||||:||:.||.:...|:..::..||.||||||..|...||.:|:..    ::..::..
Human   308 PDILCSAKRLKLLMQPLSSIHVRTETLALTKLEVWWYLLMRLGPHLPANFEQVCVPLIQSTISID 372

  Fly   248 LGGGPR----NLAT------------GLAHNYQTARELALPCLVALWGVESSEPLQRLMRELRLE 296
            ....|:    ::||            |.:..|.......:.....|.|:.:...:|.|..|:.|.
Human   373 SNASPQGNSCHVATSPGLNPMTPVHKGASSPYGAPGTPRMNLSSNLGGMATIPSIQLLGLEMLLH 437

  Fly   297 TLVQPSPL---------MSVE-----------VFQQHWKPLLAAA-------------------- 321
            .|:.|..|         :|:|           .|.:|...|:.|.
Human   438 FLLGPEALSFAKQNKLVLSLEPLEHPLISSPSFFSKHANTLITAVHDSFVAVGKDAPDVVVSAIW 502

  Fly   322 ---VSGLKLLTE--NDATEAEQLLLQLLVRNLCLAMFRLAVAPFNVACCSEIEKILQAEDNSGGR 381
               :|.:|.:||  |...:....:|.||:::|                    |.|:::|.....:
Human   503 KELISLVKSVTESGNKKEKPGSEVLTLLLKSL--------------------ESIVKSEVFPVSK 547

  Fly   382 VVRALFNTIAADNLVMERVSGSD-----HLDVLEA-----YLKLVLKSKTEVPAA------ILQR 430
            .:..:..||..   :.::|.||.     ::|:|..     .::|:..:..|...:      .|:.
Human   548 TLVLMEITIKG---LPQKVLGSPAYQVANMDILNGTPALFLIQLIFNNFLECGVSDERFFLSLES 609

  Fly   431 SIACI---------FAVDRIEANNQNEFRM-------------LGSFAELLMQAND-------EE 466
            .:.|:         |:...:...|||..::             :....||:.|.|:       |.
Human   610 LVGCVLSGPTSPLAFSDSVLNVINQNAKQLENKEHLWKMWSVIVTPLTELINQTNEVNQGDALEH 674

  Fly   467 DFEGF--AFKLQVWRQVSQALSNYLRNNALEYRVAHNASLLDTWLLWPLQTLAAFAGRRA----- 524
            :|...  |..|.|         |::.:.. .:.||...:||.||    .:...|||...|
Human   675 NFSAIYGALTLPV---------NHIFSEQ-RFPVATMKTLLRTW----SELYRAFARCAALVATA 725

  Fly   525 ---------SNSFDASFCDQW--------------RQLVNAGQNAPGRKKFLTDLKATL--TDLL 564
                     |:...:|..|:.              ..:|:....:|...|:...:|:..  :|..
Human   726 EENLCCEELSSKIMSSLEDEGFSNLLFVDRIIYIITVMVDCIDFSPYNIKYQPKVKSPQRPSDWS 790

  Fly   565 KSKDEPL--FAELFDAYVTSLIKFGLC--KEA------PLYKDVFGLLQTI---FEQPSSQKTLE 616
            |.|:|||  ...||...|..:..|...  |||      .:...:.|::.::   ...||..:.:.
Human   791 KKKNEPLGKLTSLFKLIVKVIYSFHTLSFKEAHSDTLFTIGNSITGIISSVLGHISLPSMIRKIF 855

  Fly   617 A-----------------------CLNT-------------------------LRNL-----VVE 628
            |                       |||.                         |..|     ::.
Human   856 ATLTRPLALFYENSKLDEVPKVYSCLNNKLEKLLGEIIACLQFSYTGTYDSELLEQLSPLLCIIF 920

  Fly   629 LRQNE-----------------LMVVF-DSLKPTLSS----------GIQCWNKMKCEGG----- 660
            |.:|:                 :|:|: :.|||.|:.          |::....|:...|
Human   921 LHKNKQIRKQSAQFWNATFAKVMMLVYPEELKPVLTQAKQKFLLLLPGLETVEMMEESSGPYSDG 985

  Fly   661 -----------------------FL-------EEWKRGIQEKFRKLPMKTMANQLKELFKADDLF 695
                                   ||       |..|...:.|.....:|.....|.|..|:.| |
Human   986 TENSQLNVKISGMERKSNGKRDSFLAQTKNKKENMKPAAKLKLESSSLKVKGEILLEEEKSTD-F 1049

  Fly   696 VIIPSVWSLNPEK-LTDRQKERF-AEKSDIPALYNDMSQSQDSASIKPWTPKKVVIAKSKQGE-- 756
            |.||.......|: |||.|||.. .::.||||:||::..|||:           :..:..|.|
Human  1050 VFIPPEGKDAKERILTDHQKEVLKTKRCDIPAMYNNLDVSQDT-----------LFTQYSQEEPM 1103

  Fly   757 ----LALTGKDDNGEVIDITASEESEKEPVRVDVVTP--IRKKPGRKSQAQKELEAAARAASLAE 815
                |....|:|:..:|        .:|.:..|:|.|  :.:..|.....:|...:.....||.:
Human  1104 EIPTLTRKPKEDSKMMI--------TEEQMDSDIVIPQDVTEDCGMAEHLEKSSLSNNECGSLDK 1160

  Fly   816 EPPKRQTRTRAAQKE---------TEQVAQPQPAFEPQLRSPKKLPPSPVVQSTAAAVKQAKVAK 871
            ..|:........:|:         ||..:..:.:|        .:..|.|..:|.|.......::
Human  1161 TSPEMSNSNNDERKKALISSRKTSTECASSTENSF--------VVSSSSVSNTTVAGTPPYPTSR 1217

  Fly   872 PTPVVVIAQSEDLFPEVAAEPEP-QPEPVKKPDPVPETTQLTPPDVPLEAVPSTQLPGSSGDPAA 935
            ....:.:.:.:      .:|..| .|.|:................:..:.:|..:....:...:.
Human  1218 RQTFITLEKFD------GSENRPFSPSPLNNISSTVTVKNNQETMIKTDFLPKAKQREGTFSKSD 1276

  Fly   936 SAGAVAAGEMSPKKSGTRIYNLSSPPDRKQTNNS-SSPTLRPKPTGHLTGRGAQLINMIRN---- 995
            |...|...:.|.:::|          ..:||.|. |.|.:|.:|..: |....:.|.::.|
Human  1277 SEKIVNGTKRSSRRAG----------KAEQTGNKRSKPLMRSEPEKN-TEESVEGIVVLENNPPG 1330

  Fly   996 --KKLDAASGSPYACMSTSRLVHQVTPARAQDRAEQVSTPTSELNELTGTDHTSTPIQAPP---S 1055
              .:.:..|.: ...:|.|.:.|..|..:|......|...|:.:.|.....:..:....||   |
Human  1331 LLNQTECVSDN-QVHLSESTMEHDNTKLKAATVENAVLLETNTVEEKNVEINLESKENTPPVVIS 1394

  Fly  1056 KDLLVFSKRLPSPSASPSVSILKR--KLRCESLDDVT----LDSPALKRKRVSFHDPPVSVTKEY 1114
            .|.:|  ........:|:...|:|  :.|.|.::..|    .::...|::|....:.|:..:..:
Human  1395 ADQMV--NEDSQVQITPNQKTLRRSSRRRSEVVESTTESQDKENSHQKKERRKEEEKPLQKSPLH 1457

  Fly  1115 LRDAEETRSSLKPKRCLLMDKVAQTTEMRQALRRRGRLDSIIE----IERFASEQTARTATTDKS 1175
            ::|      .:.||:.|:.::..|              :::||    :......:|:..|.|:::
Human  1458 IKD------DVLPKQKLIAEQTLQ--------------ENLIEKGSNLHEKTLGETSANAETEQN 1502

  Fly  1176 LDKSTGEAPEEDAFTSLKWNDTGNAHNISISEEPVKAMEVESELETAGQDLAIMDPEAALDLAVA 1240
            ..|:..|        ::|....|....:..|.|.:.......:...|.|.|
Human  1503 KKKADPE--------NIKSEGDGTQDIVDKSSEKLVRGRTRYQTRRASQGL-------------- 1545

  Fly  1241 QLPLESVLQRYFDKSPLKSAGMLAK-----------FLSAQMTANEKLKTNVLETLSENHSKDFL 1294
               |.|:.....|.|..|..|...|           .:..|....:.:|...::  :||.|.|:
Human  1546 ---LSSIENSESDSSEAKEEGSRKKRSGKWKNKSNESVDIQDQEEKVVKQECIK--AENQSHDY- 1604

  Fly  1295 DHAVRE---NLSSVVCDRLNPTSVLEYVCAKSKISASCRNGLLAQVPEILKSGPRSDSERLAFVQ 1356
             .|..|   ::.|.:|::.:.::.:  :|..|.:::.     |.|||:.|.:.....:|...:.:
Human  1605 -KATSEEDVSIKSPICEKQDESNTV--ICQDSTVTSD-----LLQVPDDLPNVCEEKNETSKYAE 1661

  Fly  1357 QLMVQCSPGDDLLLDLIDLLMRTR----RERNNSTSTHISKGVVSAVGSPD 1403
            .....        |.:.:..:|||    |.....:..:.|.|..|.:|..|
Human  1662 YSFTS--------LPVPESNLRTRNAIKRLHKRDSFDNCSLGESSKIGISD 1704

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rif1	NP_725497.1	Rif1_N	<110..240	CDD:315005	51/138 (37%)
		Atrophin-1	705..>1129	CDD:331285	83/459 (18%)
		GGN	<827..920	CDD:330621	12/102 (12%)
RIF1	NP_060621.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..25
		Rif1_N	20..361	CDD:289035	60/182 (33%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1145..1192		7/46 (15%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1265..1318		12/63 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1398..1464		11/73 (15%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1479..1587		22/132 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1762..1782
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1846..1889
		Interaction with condensed chromosomes in telophase	1924..2472
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1992..2021
		Interaction with ERCC6. /evidence=ECO:0000269\|PubMed:29203878	2170..2446
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2227..2269
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165159332
Domainoid	1	1.000	84	1.000	Domainoid score	I8280
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0007187
OrthoInspector	1	1.000	-	-		oto90182
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR22928
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	7	6.990