DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Rif1 and Rif1

DIOPT Version :9

Sequence 1:	NP_725497.1	Gene:	Rif1 / 246445	FlyBaseID:	FBgn0050085	Length:	1416	Species:	Drosophila melanogaster
Sequence 2:	NP_001342343.1	Gene:	Rif1 / 51869	MGIID:	1098622	Length:	2426	Species:	Mus musculus

Alignment Length:	1736	Identity:	346/1736 - (19%)
Similarity:	556/1736 - (32%)	Gaps:	640/1736 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly    62 WLGDILPLMFDADRKIQDCAVAALAEAL---------VALDVSVIHSAKCWPQIRSEFVDK-YTI 116
            |...::||:..:.:|:......||...:         :||....:.:.|...:::..|.:| .|.
Mouse   191 WAKLVIPLVVHSAQKVHLRGATALEMGMPLLLQKQQEIALITEHLMTTKLISELQKLFKNKNETY 255

  Fly   117 IIGEMRDAKNSNWHKIWTLLVQIMDEDLLRGCVYINKFLALVELGFRNPDNGVRSEAFLCWRVLI 181
            ::            |:|.|.|:::.:.|.|...:||..|.|.|||||:....::..||:.|:.||
Mouse   256 VL------------KLWPLFVKLLGKTLHRSGSFINSLLQLEELGFRSGTPMIKKIAFIAWKSLI 308

  Fly   182 KIFAAY-DELTSAKRLRLLLIPLRTSQSRSSHVSGIKLRVWWYLLSCLDHELPKSFDSAVEHFLA 245
            ..||.. |.|.|||||:||:.||.:...|:..::..||.||||||..|..:||.:|:......:.
Mouse   309 DNFALNPDILCSAKRLKLLMQPLSSIHVRTETLALTKLEVWWYLLMRLGPQLPANFEQVCVPLIQ 373

  Fly   246 FMLG---------------------------------GGPR-NLATGLAHNYQTARELALPCLVA 276
            ..:.                                 |.|| ||::      .|....|:|. :.
Mouse   374 STISVDSIPSPQGNSSRGSASPGLSPLTPGHKGASPYGSPRGNLSS------NTGGMAAIPS-IQ 431

  Fly   277 LWGVE----------------------SSEPLQRLMRELRLETLVQPSPLMSVEVFQQHWKPLLA 319
            |.|:|                      |.|||:.              ||:|...|...:...|.
Mouse   432 LLGLEMMLHFLLGPEVLSFAKQHKIVLSLEPLEH--------------PLISSPSFFSKYAHTLI 482

  Fly   320 AAVSGLKLLTENDATEAEQLLLQLLVRNLCLAMFRLAVAPFNVACCSEIEKILQA---EDNSGGR 381
            .||....:....||::|   ::..:.:.|                .|.::.:.:|   ::.||..
Mouse   483 TAVHDSFVSVGKDASDA---VVSAIWKEL----------------ISLVKSVTEAGNRKEKSGSE 528

  Fly   382 VVRALFNTIAADNLV-------------ME--------RVSGSD-----HLDVLEAYLKLVLKSK 420
            |:..|..::  :|:|             ||        :|.||.     ::|:|..
Mouse   529 VLTLLLKSL--ENIVKSEVFPVSKTLVLMEITVKGLPPKVLGSPAYQVANMDILNG--------- 582

  Fly   421 TEVPAAILQRSIACIFAVDRIEANNQNEFRMLG----------------SFAELLMQANDEEDFE 469
              .||..|   |..||..:.:|...::|...|.                :|::.::...: ::.:
Mouse   583 --TPALFL---IQLIFNNNLLECGVEDEKFFLNLETLVGCVLSGPTSPLAFSDSVLTVIN-QNAK 641

  Fly   470 GFAFKLQVWRQVSQALS----------NYLRNNALEYRVAHNAS--------------------- 503
            ....|..:||..|..:|          ...:.:|||    ||.|
Mouse   642 QLVNKEHLWRMWSMIVSPLTDVIHQTNEVNQGDALE----HNFSAIYGALTLPINHIFSAQTFPT 702

  Fly   504 -----LLDTWL-LWPLQTLAAFAGRRASNSF-------------------DASFCDQWRQ----L 539
                 ||.||. |:...|..|.....|..:.                   |..|.|:...    :
Mouse   703 GTMKALLKTWSELYRAFTRCASLVATAEENLCCEELSSKIMCSLEDEVLSDLLFLDRISHIIIVM 767

  Fly   540 VNAGQNAPGRKKFLTDLKA--TLTDLLKSKDEPL--FAELFDAYVTSLIKFGLCKEAPLYKD--- 597
            |:....:|..||:...:|:  ..:|..:.|.|||  .|.||...|..:..|........:.|
Mouse   768 VDCIDFSPYNKKYQPKIKSPQRSSDWSRKKKEPLGKLASLFKLIVKVIDTFHTLSLKETFSDTLL 832

  Fly   598 ------------VFG------LLQTIF-----------------EQPSSQKTLEACLNTLRNLVV 627
                        |||      :::.||                 |.|....:|...|..|...:|
Mouse   833 AIGNSIISMLSNVFGHISLPSMIREIFATFTRPLALLYENSKLDEAPKVYTSLNNKLEKLLGEIV 897

  Fly   628 ELRQNELMVVFDS-----LKPTL------------SSGIQCWN---------------------- 653
            ...|...:..:||     |.|.|            ......||
Mouse   898 ACLQFSYLGAYDSELLEHLSPLLCVIFLHKNKQIRKQSALLWNATFAKATALVYPEELKPILRQA 962

  Fly   654 ---------------------------------KMKCEGGFLEEWKRG--------IQEKFRKLP 677
                                             .:|..|  :|....|        .::|.:|:.
Mouse   963 KQKILLLLPGLENVEMMDESSEPYSESTENSQLNVKISG--MERKSSGKRDSILAHTKDKKKKVK 1025

  Fly   678 M-----------KTMANQLKELFKADDLFVIIPSVWSLNPEKLTDRQKERF-AEKSDIPALYNDM 730
            :           |..:.:|.|..|:.|...|.|.........||:.|||.. .::.|||||||::
Mouse  1026 LSAKLKLESSSPKIKSGKLLEEEKSTDFVFIPPEGKETKARVLTEHQKEVLKTKRCDIPALYNNL 1090

  Fly   731 SQSQD---SASI-------------KPWTPKKVVIAKSKQGELAL---------TGKDDNGEVID 770
            ..|||   ||..             ||....|::  |.:|.|..:         .|.|::.|...
Mouse  1091 DASQDTLFSAQFSQEESMESLTLTEKPKEDAKII--KEEQMESTIFIHQDAPENCGIDEHSENAS 1153

  Fly   771 ITASEESEKEPVRVDVVTPIRKKPGRKSQAQKELEAAARAASLAEEPPKRQT---RTRAAQKETE 832
            :.....|..|.....::|..        .|:||:..:::..| ||.....:|   .:.:....|.
Mouse  1154 LPNCGGSVAETNPETLITGF--------DARKEVLISSKILS-AESSSSTETSVVSSSSVSNATF 1209

  Fly   833 QVAQPQPAFEPQL---------RSPKKLPPSPV--VQSTAAAVKQ----------AKVAKPTPVV 876
            ....|||....|.         ...:...|||:  :.||......          .|..|.....
Mouse  1210 SGTPPQPTSRRQTFITLEKFDGSETRPFSPSPLNNISSTVTVRNNQDNTTNTDMPPKARKREVTN 1274

  Fly   877 VIAQSEDLF----------------------PEVAAEPEPQPEPVKKPDPVPETTQLTP-PDVPL 918
            ..:.||:|.                      |.:.:|.|........||.:..|..::. .|.|.
Mouse  1275 SKSDSENLANAGKKSSRRWSKAEQSVTKKSKPSLTSEQEEHSSENNSPDLLSPTEHVSENDDHPS 1339

  Fly   919 EAVPSTQLPGSSGDPAASAGAVAAGEMSPKKSGTRIYNLSSP---------PDRKQTNNSSSPTL 974
            ||.    |....|||..:....:..:::.::....| |:.|.         .::....:|.:..|
Mouse  1340 EAT----LEHKDGDPKPAVENASLEDLTTEEKNVGI-NMESKESTASVVARTEQIVNEDSQAAAL 1399

  Fly   975 RPKPTGHLTGRGAQLINMIRNKKLDAASGSPYACMSTSRLVHQVTPARAQDRAEQVS-------- 1031
            .|.|      :..:..:..|::.:|:.|.      |..|...|....|.::..:.:|
Mouse  1400 APNP------KTLRRSSRRRSEAVDSCSD------SQERESGQQKKERRKEEEKIISKSPLRIKD 1452

  Fly  1032 --TPTSELNELTGTDHTSTPIQAPPSKDLLVFSKRLPS-PSASPSVSI-LKRKLRCESLDDV--- 1089
              .||.:|.:       .:|||    ::|......||. .|..|||:. :.:..|...|::|
Mouse  1453 DKLPTQKLTD-------ESPIQ----ENLTEKGNTLPERTSGEPSVNAEIDQNRRKPDLENVSSE 1506

  Fly  1090 ----TLDSPALKRKRVSFHDPPVSVTKEYLRDAEETRSSLKPKRCLLMDKVAQTTEMRQALRRRG 1150
                |||:                          ..:||.||.|          ...|...||..
Mouse  1507 GGGGTLDN--------------------------LDKSSEKPLR----------GRTRYQTRRAS 1535

  Fly  1151 R-LDSIIEIERFASEQTARTATTDKSLDKSTGEAPEEDAFTSLKWNDTGNAHNISISEEPVKAME 1214
            : |.|.:|    .||..:..|..:.|..|.:|           ||.:. ::.::.|.|:..|..|
Mouse  1536 QGLISAVE----NSESDSSEAKEEVSRKKRSG-----------KWKNR-SSDSVDIEEQEEKKAE 1584

  Fly  1215 VESELETAGQDLAIMDPEAALDL---AVAQLPLES------VLQRYFDKSPLKSAGMLAKFLSAQ 1270
             |..::||.|.|   |.:|..|:   |.||:..:|      :||        .|||. |..|.|.
Mouse  1585 -EEVMKTANQTL---DGQAVPDVDVNAAAQVCEKSTNNNRVILQ--------DSAGP-ADSLQAP 1636

  Fly  1271 MTANEKLKTN-----------VLET--LSENHSKDFL-----DHAVRENLSSVVCDRLNPTSVLE 1317
            ....||.|.|           |.|:  .:.|.||..|     |..||.:.||     |:|....:
Mouse  1637 PKGEEKSKINKCVDSSFVSLPVPESNLRTRNASKRLLYKQDNDSNVRVSDSS-----LSPEKFTQ 1696

  Fly  1318 YVC--------AKSKISASCRNGLLAQVPEILKSGPRSDSERLAFV 1355
            ..|        .:||....|              |.:|.|:..:|:
Mouse  1697 VECQHKRSRRVRRSKSCDCC--------------GEKSQSQEKSFI 1728

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rif1	NP_725497.1	Rif1_N	<110..240	CDD:315005	49/131 (37%)
		Atrophin-1	705..>1129	CDD:331285	103/524 (20%)
		GGN	<827..920	CDD:330621	23/136 (17%)
Rif1	NP_001342343.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..24
		Rif1_N	25..368	CDD:315005	58/187 (31%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	380..415		12/57 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1191..1601		80/339 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1620..1644
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1819..1843
		Interaction with condensed chromosomes in telophase. /evidence=ECO:0000250	1889..2426
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1897..1921
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1936..1990
		Interaction with ERCC6. /evidence=ECO:0000250\|UniProtKB:Q5UIP0	2126..2401
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2189..2219
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167849699
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_2CNCB
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0007187
OrthoInspector	1	1.000	-	-		oto93758
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR22928
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1100
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	8	7.920